In enzymology, a glucosylceramidase (EC 184.108.40.206) is an enzyme that catalyzes the chemical reaction
- D-glucosyl-N-acylsphingosine + H2O D-glucose + N-acylsphingosine
Thus, the two substrates of this enzyme are D-glucosyl-N-acylsphingosine and H2O, whereas its two products are D-glucose and N-acylsphingosine.
This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is D-glucosyl-N-acylsphingosine glucohydrolase. Other names in common use include psychosine hydrolase, glucosphingosine glucosylhydrolase, GlcCer-beta-glucosidase, beta-D-glucocerebrosidase, glucosylcerebrosidase, beta-glucosylceramidase, ceramide glucosidase, glucocerebrosidase, glucosylsphingosine beta-glucosidase, and glucosylsphingosine beta-D-glucosidase. This enzyme participates in sphingolipid metabolism and glycan structures - degradation.
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1OGS, 1Y7V, 2F61, 2J25, 2NSX, 2NT0, 2NT1, 2V3D, and 2V3E.
Human proteins containing this domain
- The CAS registry number for this enzyme class is 37228-64-1.
Gene Ontology (GO) codes