Maltase-glucoamylase

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Maltase-glucoamylase, intestinal is an enzyme that in humans is encoded by the MGAM gene.[1][2]

Maltase-glucoamylase is an alpha-glucosidase digestive enzyme. It consists of two subunits with differing substrate specificity. Recombinant enzyme studies have shown that its N-terminal catalytic domain has highest activity against maltose, while the C-terminal domain has a broader substrate specificity and activity against glucose oligomers.[3] In the small intestine, this enzyme works in synergy with sucrase-isomaltase and alpha-amylase to digest the full range of dietary starches.

See also

References

  1. "Entrez Gene: maltase-glucoamylase (alpha-glucosidase)".
  2. Nichols BL, Eldering J, Avery S, Hahn D, Quaroni A, Sterchi E (January 1998). "Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase". J. Biol. Chem. 273 (5): 3076–81. doi:10.1074/jbc.273.5.3076. PMID 9446624.
  3. Quezada-Calvillo R, Sim L, Ao Z, Hamaker BR, Quaroni A, Brayer GD, Sterchi EE, Robayo-Torres CC, Rose DR, Nichols BL (2008). "Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit". J. Nutr. 138 (4): 685–92. PMID 18356321.

Further reading



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