Kaposi's sarcoma differential diagnosis: Difference between revisions
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| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Anorexia]] | * [[Anorexia]] | ||
* [[Weight loss]] | * [[Weight loss]] | ||
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| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* Lobular vascular proliferations of [[Blood vessel|vessels]] lined by plump [[Endothelium|endothelial cells]] | * Lobular vascular proliferations of [[Blood vessel|vessels]] lined by plump [[Endothelium|endothelial cells]] | ||
| style="background:#F5F5F5;" align="center" | Clinical manifestation | | style="background:#F5F5F5;" align="center" | Clinical manifestation | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
*[[Mental disorder|Psychiatric disorders]] | *[[Mental disorder|Psychiatric disorders]] | ||
*[[Personality|Personality changes]] | *[[Personality|Personality changes]] | ||
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| style="background:#F5F5F5;" align="left" | | | style="background:#F5F5F5;" align="left" | | ||
* [[Idiopathic]] | * [[Idiopathic]] | ||
| style="background:#F5F5F5;" align="center" | + | | style="background:#F5F5F5;" align="center" | + | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
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| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Headache]] | * [[Headache]] | ||
* [[Neurologic diseases|Neurologic deficits]] | * [[Neurologic diseases|Neurologic deficits]] | ||
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| style="background:#F5F5F5;" align="center" |NA | | style="background:#F5F5F5;" align="center" |NA | ||
| style="background:#F5F5F5;" align="center" | [[Imaging]] | | style="background:#F5F5F5;" align="center" | [[Imaging]] | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Hereditary hemorrhagic telangiectasia]] | * [[Hereditary hemorrhagic telangiectasia]] | ||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Acroangiodermatitis]]<ref name="pmid17868541">{{cite journal |vauthors=Lugović L, Pusić J, Situm M, Buljan M, Bulat V, Sebetić K, Soldo-Belić A |title=Acroangiodermatitis (pseudo-Kaposi sarcoma): three case reports |journal=Acta Dermatovenerol Croat |volume=15 |issue=3 |pages=152–7 |date=2007 |pmid=17868541 |doi= |url=}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Acroangiodermatitis]]<ref name="pmid17868541">{{cite journal |vauthors=Lugović L, Pusić J, Situm M, Buljan M, Bulat V, Sebetić K, Soldo-Belić A |title=Acroangiodermatitis (pseudo-Kaposi sarcoma): three case reports |journal=Acta Dermatovenerol Croat |volume=15 |issue=3 |pages=152–7 |date=2007 |pmid=17868541 |doi= |url=}}</ref> | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Idiopathic]] | * [[Idiopathic]] | ||
* Hyperplasia of pre-existing vasculature | * Hyperplasia of pre-existing vasculature | ||
* [[Hypertension|HTN]] | * [[Hypertension|HTN]] | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
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| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* Paralysed legs | * Paralysed legs | ||
| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
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| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Hyperkeratosis]] | * [[Hyperkeratosis]] | ||
* Parakeratosis | * Parakeratosis | ||
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* Mild spongiosis | * Mild spongiosis | ||
| style="background:#F5F5F5;" align="center" | Clinical manifesttations | | style="background:#F5F5F5;" align="center" | Clinical manifesttations | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Amputation]] | * [[Amputation]] | ||
* [[Hemodialysis|Haemodialysis]] patients with [[Arteriovenous fistula|arteriovenous shunts]] | * [[Hemodialysis|Haemodialysis]] patients with [[Arteriovenous fistula|arteriovenous shunts]] | ||
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|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" | [[Angiosarcoma]] <ref name="pmid2734404">{{cite journal |vauthors=Barttelbort SW, Stahl R, Ariyan S |title=Cutaneous angiosarcoma of the face and scalp |journal=Plast. Reconstr. Surg. |volume=84 |issue=1 |pages=55–9 |date=July 1989 |pmid=2734404 |doi= |url=}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" | [[Angiosarcoma]] <ref name="pmid2734404">{{cite journal |vauthors=Barttelbort SW, Stahl R, Ariyan S |title=Cutaneous angiosarcoma of the face and scalp |journal=Plast. Reconstr. Surg. |volume=84 |issue=1 |pages=55–9 |date=July 1989 |pmid=2734404 |doi= |url=}}</ref> | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Idiopathic]] | * [[Idiopathic]] | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
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| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* Intercellular and intracellular lumina with or without [[Red blood cell|red cells]] | * Intercellular and intracellular lumina with or without [[Red blood cell|red cells]] | ||
* Intermediate filaments and pinocytotic vesicles in [[cytoplasm]] | * Intermediate filaments and pinocytotic vesicles in [[cytoplasm]] | ||
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|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Masson's [[hemangioma]] <ref name="pmid22993679">{{cite journal |vauthors=Park KK, Won YS, Yang JY, Choi CS, Han KY |title=Intravascular Papillary Endothelial Hyperplasia (Masson tumor) of the Skull : Case Report and Literature Review |journal=J Korean Neurosurg Soc |volume=52 |issue=1 |pages=52–4 |date=July 2012 |pmid=22993679 |pmc=3440504 |doi=10.3340/jkns.2012.52.1.52 |url=}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |Masson's [[hemangioma]] <ref name="pmid22993679">{{cite journal |vauthors=Park KK, Won YS, Yang JY, Choi CS, Han KY |title=Intravascular Papillary Endothelial Hyperplasia (Masson tumor) of the Skull : Case Report and Literature Review |journal=J Korean Neurosurg Soc |volume=52 |issue=1 |pages=52–4 |date=July 2012 |pmid=22993679 |pmc=3440504 |doi=10.3340/jkns.2012.52.1.52 |url=}}</ref> | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Idiopathic]] | * [[Idiopathic]] | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" |Rare | | style="background:#F5F5F5;" align="center" |Rare | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* Normal | * Normal | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
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| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* Papillary fronds lined by proliferating [[endothelium]] | * Papillary fronds lined by proliferating [[endothelium]] | ||
| style="background:#F5F5F5;" align="center" | [[Biopsy]] | | style="background:#F5F5F5;" align="center" | [[Biopsy]] | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Hemangioma]] | * [[Hemangioma]] | ||
* [[Pyogenic granuloma|Pyogenic granulomas]] | * [[Pyogenic granuloma|Pyogenic granulomas]] | ||
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|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Seborrheic keratosis]] <ref name="pmid18845088">{{cite journal |vauthors=Noiles K, Vender R |title=Are all seborrheic keratoses benign? Review of the typical lesion and its variants |journal=J Cutan Med Surg |volume=12 |issue=5 |pages=203–10 |date=2008 |pmid=18845088 |doi=10.2310/7750.2008.07096 |url=}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Seborrheic keratosis]] <ref name="pmid18845088">{{cite journal |vauthors=Noiles K, Vender R |title=Are all seborrheic keratoses benign? Review of the typical lesion and its variants |journal=J Cutan Med Surg |volume=12 |issue=5 |pages=203–10 |date=2008 |pmid=18845088 |doi=10.2310/7750.2008.07096 |url=}}</ref> | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* Clonal expansion of a mutated epidermal [[keratinocyte]] | * Clonal expansion of a mutated epidermal [[keratinocyte]] | ||
| style="background:#F5F5F5;" align="center" | + | | style="background:#F5F5F5;" align="center" | + | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | Any age | | style="background:#F5F5F5;" align="center" | Any age | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* Usually [[asymptomatic]] | * Usually [[asymptomatic]] | ||
* Being stuck on the skin surface | * Being stuck on the skin surface | ||
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| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* Papillomatous epithelial proliferation containing horn [[Cyst|cysts]] | * Papillomatous epithelial proliferation containing horn [[Cyst|cysts]] | ||
| style="background:#F5F5F5;" align="center" | Clinical manifestations | | style="background:#F5F5F5;" align="center" | Clinical manifestations | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Dermatosis papulosa nigra]] | * [[Dermatosis papulosa nigra]] | ||
* Stucco keratosis | * Stucco keratosis | ||
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|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Systemic lupus erythematosus]] ([[SLE]]) <ref name="pmid22888407">{{cite journal |vauthors=Uva L, Miguel D, Pinheiro C, Freitas JP, Marques Gomes M, Filipe P |title=Cutaneous manifestations of systemic lupus erythematosus |journal=Autoimmune Dis |volume=2012 |issue= |pages=834291 |date=2012 |pmid=22888407 |pmc=3410306 |doi=10.1155/2012/834291 |url=}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Systemic lupus erythematosus]] ([[SLE]]) <ref name="pmid22888407">{{cite journal |vauthors=Uva L, Miguel D, Pinheiro C, Freitas JP, Marques Gomes M, Filipe P |title=Cutaneous manifestations of systemic lupus erythematosus |journal=Autoimmune Dis |volume=2012 |issue= |pages=834291 |date=2012 |pmid=22888407 |pmc=3410306 |doi=10.1155/2012/834291 |url=}}</ref> | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Idiopathic]] | * [[Idiopathic]] | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | More common in female, typically in the 20 to 30 years | | style="background:#F5F5F5;" align="center" | More common in female, typically in the 20 to 30 years | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Erythema]] on the [[Mouth|nasolabial folds]] | * [[Erythema]] on the [[Mouth|nasolabial folds]] | ||
* [[Macule|Macular]] or diffusely erythematous in sun-exposed areas | * [[Macule|Macular]] or diffusely erythematous in sun-exposed areas | ||
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| style="background:#F5F5F5;" align="center" | ± | | style="background:#F5F5F5;" align="center" | ± | ||
| style="background:#F5F5F5;" align="center" | ± | | style="background:#F5F5F5;" align="center" | ± | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Weight loss]] | * [[Weight loss]] | ||
* [[Headache]] | * [[Headache]] | ||
* [[Arthralgia]] | * [[Arthralgia]] | ||
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| style="background:#F5F5F5;" align="center" |Nl | | style="background:#F5F5F5;" align="center" |Nl | ||
| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Hyperkeratosis]], epidermal [[atrophy]], vacuolar interface [[dermatitis]] | * [[Hyperkeratosis]], epidermal [[atrophy]], vacuolar interface [[dermatitis]] | ||
* Thickening of the [[basement membrane]] | * Thickening of the [[basement membrane]] | ||
* Superficial, [[Perivascular cell|perivascular]], and perifollicular [[Monocyte|mononuclear cell]] inflammatory infiltrate | * Superficial, [[Perivascular cell|perivascular]], and perifollicular [[Monocyte|mononuclear cell]] inflammatory infiltrate | ||
| style="background:#F5F5F5;" align="center" | Clinical manifestations | | style="background:#F5F5F5;" align="center" | Clinical manifestations | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Raynaud's phenomenon|Raynaud phenomenon]] | * [[Raynaud's phenomenon|Raynaud phenomenon]] | ||
* [[Neuropsychiatry|Neuropsychiatric]] symptoms | * [[Neuropsychiatry|Neuropsychiatric]] symptoms | ||
* [[Pleural effusion]] | * [[Pleural effusion]] | ||
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|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Pyogenic]] granuloma <ref name="pmid22434943">{{cite journal |vauthors=Kamal R, Dahiya P, Puri A |title=Oral pyogenic granuloma: Various concepts of etiopathogenesis |journal=J Oral Maxillofac Pathol |volume=16 |issue=1 |pages=79–82 |date=January 2012 |pmid=22434943 |pmc=3303528 |doi=10.4103/0973-029X.92978 |url=}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Pyogenic]] granuloma <ref name="pmid22434943">{{cite journal |vauthors=Kamal R, Dahiya P, Puri A |title=Oral pyogenic granuloma: Various concepts of etiopathogenesis |journal=J Oral Maxillofac Pathol |volume=16 |issue=1 |pages=79–82 |date=January 2012 |pmid=22434943 |pmc=3303528 |doi=10.4103/0973-029X.92978 |url=}}</ref> | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Physical trauma|Trauma]] | * [[Physical trauma|Trauma]] | ||
* Hormonal influences | * Hormonal influences | ||
* [[Virus|Viruses]] | * [[Virus|Viruses]] | ||
* Cytogenetic clonal deletion abnormalities | * Cytogenetic clonal deletion abnormalities | ||
| style="background:#F5F5F5;" align="center" | + | | style="background:#F5F5F5;" align="center" | + | ||
| style="background:#F5F5F5;" align="center" | + | | style="background:#F5F5F5;" align="center" | + | ||
| style="background:#F5F5F5;" align="center" | Any age, usually in 20-30 years | | style="background:#F5F5F5;" align="center" | Any age, usually in 20-30 years | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* Painless red lesion | * Painless red lesion | ||
* Lobular [[capillary hemangioma]] | * Lobular [[capillary hemangioma]] | ||
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| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* Neutrophilic infiltration | * Neutrophilic infiltration | ||
* [[Bleeding|Hemorrhage]] | * [[Bleeding|Hemorrhage]] | ||
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|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Benign lymphangioendothelioma <ref name="pmid10935645">{{cite journal |vauthors=Guillou L, Fletcher CD |title=Benign lymphangioendothelioma (acquired progressive lymphangioma): a lesion not to be confused with well-differentiated angiosarcoma and patch stage Kaposi's sarcoma: clinicopathologic analysis of a series |journal=Am. J. Surg. Pathol. |volume=24 |issue=8 |pages=1047–57 |date=August 2000 |pmid=10935645 |doi= |url=}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |Benign lymphangioendothelioma <ref name="pmid10935645">{{cite journal |vauthors=Guillou L, Fletcher CD |title=Benign lymphangioendothelioma (acquired progressive lymphangioma): a lesion not to be confused with well-differentiated angiosarcoma and patch stage Kaposi's sarcoma: clinicopathologic analysis of a series |journal=Am. J. Surg. Pathol. |volume=24 |issue=8 |pages=1047–57 |date=August 2000 |pmid=10935645 |doi= |url=}}</ref> | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Idiopathic]] | * [[Idiopathic]] | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | + | | style="background:#F5F5F5;" align="center" | + | ||
| style="background:#F5F5F5;" align="center" | Any ages, median age is 50 years | | style="background:#F5F5F5;" align="center" | Any ages, median age is 50 years | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* single, slowly expanding patch, [[plaque]], or [[Nodule (medicine)|nodule]] | * single, slowly expanding patch, [[plaque]], or [[Nodule (medicine)|nodule]] | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
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| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* Thin-walled endothelial-lined spaces that are interspersed between strands of [[collagen]] | * Thin-walled endothelial-lined spaces that are interspersed between strands of [[collagen]] | ||
| style="background:#F5F5F5;" align="center" |[[Biopsy]] | | style="background:#F5F5F5;" align="center" |[[Biopsy]] | ||
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|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Cavernous [[hemangioma]] <ref name="pmid229814">{{cite journal |vauthors=Goldberg RE, Pheasant TR, Shields JA |title=Cavernous hemangioma of the retina. A four-generation pedigree with neurocutaneous manifestations and an example of bilateral retinal involvement |journal=Arch. Ophthalmol. |volume=97 |issue=12 |pages=2321–4 |date=December 1979 |pmid=229814 |doi= |url=}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |Cavernous [[hemangioma]] <ref name="pmid229814">{{cite journal |vauthors=Goldberg RE, Pheasant TR, Shields JA |title=Cavernous hemangioma of the retina. A four-generation pedigree with neurocutaneous manifestations and an example of bilateral retinal involvement |journal=Arch. Ophthalmol. |volume=97 |issue=12 |pages=2321–4 |date=December 1979 |pmid=229814 |doi= |url=}}</ref> | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Idiopathic]] | * [[Idiopathic]] | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | Usually in third to fifth decades of life. | | style="background:#F5F5F5;" align="center" | Usually in third to fifth decades of life. | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* Painless, slowly progressive protrusion or bulging of their globe | * Painless, slowly progressive protrusion or bulging of their globe | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
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| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* Engorged vascular channels, which are tightly knit and separated by [[Fiber|fibrous]] septae | * Engorged vascular channels, which are tightly knit and separated by [[Fiber|fibrous]] septae | ||
| style="background:#F5F5F5;" align="center" | Clinical manidestation | | style="background:#F5F5F5;" align="center" | Clinical manidestation | ||
| style="background:#F5F5F5;" align=" | | style="background:#F5F5F5;" align="left" | | ||
* [[Diplopia]] | * [[Diplopia]] | ||
* Decreased [[color vision]] | * Decreased [[color vision]] | ||
* [[Visual field loss|Visual field deficits]] | * [[Visual field loss|Visual field deficits]] | ||
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Revision as of 17:43, 4 October 2018
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2] Haytham Allaham, M.D. [3]
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Kaposi's sarcoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Kaposi's sarcoma differential diagnosis On the Web |
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American Roentgen Ray Society Images of Kaposi's sarcoma differential diagnosis |
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Risk calculators and risk factors for Kaposi's sarcoma differential diagnosis |
Overview
Kaposi's sarcoma must be differentiated from other diseases that cause similar cutaneous, pulmonary, and gastrointestinal involvement, such as bacillary angiomatosis, AIDS-related lymphoma, and seborrheic keratosis.
Differentiating Kaposi's Sarcoma from other Diseases
- Kaposi's sarcoma must be differentiated from other diseases that cause similar cutaneous, pulmonary, and gastrointestinal involvement.[1][2][3]
| Diseases | Etiology | Congenital | Acquired | Demography | Clinical manifestations | Lab findings | Gold standard diagnosis | Associated findings | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Symptoms | Signs | CBC | LFT | ESR/CRP | Histopathology | ||||||||||||||
| Appearance | Fever | Bleeding | BP | Hepatosplenomegaly | Lymphadenopathy | Other | WBC | Hb | Plt | ||||||||||
| Bacillary angiomatosis [4] | – | + | Any age, usually between 20 -50 years | Solitary or multiple red, purple, flesh-colored, or colorless papules | ± | ± | Nl | – | – | Nl | Nl | Nl | Nl | Nl |
|
Clinical manifestation | |||
| Arteriovenous malformation [5] | + | – | Any age | Nl | – | + | Nl | – | – | Nl | Nl | Nl | Nl | Nl | NA | Imaging | |||
| Acroangiodermatitis[6] |
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– | – | Any age, more in males | Purplish-blue to brown papules and plaques | – | – | Nl | – | – |
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Nl | Nl | Nl | Nl | Nl |
|
Clinical manifesttations | |
| Angiosarcoma [7] | – | – | Adults, more in males | Enlarging bruise, a blue-black nodule, or an unhealed ulceration | – | – | Nl | – | – | – | Nl | ↓ | ↓ | Nl | Nl |
|
Biopsy | NA | |
| Diseases | Etiology | Congenital | Acquired | Demography | Appearance | Fever | Bleeding | BP | Hepatosplenomegaly | Lymphadenopathy | Other | WBC | Hb | Plt | LFT | ESR/CRP | Histopathology | Gold standard diagnosis | Associated findings |
| Masson's hemangioma [8] | – | – | Rare |
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– | – | Nl | – | – | – | Nl | Nl | Nl | Nl | Nl |
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Biopsy | ||
| Seborrheic keratosis [9] |
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+ | – | Any age |
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– | – | Nl | – | – | – | Nl | Nl | Nl | Nl | Nl |
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Clinical manifestations |
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| Systemic lupus erythematosus (SLE) [10] | – | – | More common in female, typically in the 20 to 30 years |
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± | - | ↑ | ± | ± | ↑ | ↓ | ↓ | Nl | Nl |
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Clinical manifestations | |||
| Pyogenic granuloma [11] | + | + | Any age, usually in 20-30 years |
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– | + | Nl | – | – | – | Nl | Nl | Nl | Nl | Nl |
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Clinical manifestation | NA | |
| Benign lymphangioendothelioma [12] | – | + | Any ages, median age is 50 years | – | – | Nl | – | – | – | Nl | Nl | Nl | Nl | Nl |
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Biopsy | NA | ||
| Cavernous hemangioma [13] | – | – | Usually in third to fifth decades of life. |
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– | – | Nl | – | – | – | Nl | Nl | Nl | Nl | Nl |
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Clinical manidestation |
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| Diseases | Etiology | Congenital | Acquired | Demography | Appearance | Fever | Bleeding | BP | Hepatosplenomegaly | Lymphadenopathy | Other | WBC | Hb | Plt | LFT | ESR/CRP | Histopathology | Gold standard diagnosis | Associated findings |
References
- ↑ Kaposi's Sarcoma. Radiopaedia (2015) http://radiopaedia.org/articles/kaposi-sarcoma Accessed on January, 19 2016
- ↑ Libre Pathology. Kaposi's sarcoma (2015) http://librepathology.org/wiki/index.php/File:Kaposi_sarcoma_low_intermed_mag.jpg Accessed on January, 19 2016
- ↑ Kaposi's Sarcoma. PathologyOutlines (2015) http://www.pathologyoutlines.com/topic/skintumornonmelanocytickaposisarcoma.html Accessed on January, 19 2015
- ↑ Tappero JW, Perkins BA, Wenger JD, Berger TG (July 1995). "Cutaneous manifestations of opportunistic infections in patients infected with human immunodeficiency virus". Clin. Microbiol. Rev. 8 (3): 440–50. PMC 174635. PMID 7553576.
- ↑ Whitehead KJ, Smith MC, Li DY (February 2013). "Arteriovenous malformations and other vascular malformation syndromes". Cold Spring Harb Perspect Med. 3 (2): a006635. doi:10.1101/cshperspect.a006635. PMC 3552339. PMID 23125071.
- ↑ Lugović L, Pusić J, Situm M, Buljan M, Bulat V, Sebetić K, Soldo-Belić A (2007). "Acroangiodermatitis (pseudo-Kaposi sarcoma): three case reports". Acta Dermatovenerol Croat. 15 (3): 152–7. PMID 17868541.
- ↑ Barttelbort SW, Stahl R, Ariyan S (July 1989). "Cutaneous angiosarcoma of the face and scalp". Plast. Reconstr. Surg. 84 (1): 55–9. PMID 2734404.
- ↑ Park KK, Won YS, Yang JY, Choi CS, Han KY (July 2012). "Intravascular Papillary Endothelial Hyperplasia (Masson tumor) of the Skull : Case Report and Literature Review". J Korean Neurosurg Soc. 52 (1): 52–4. doi:10.3340/jkns.2012.52.1.52. PMC 3440504. PMID 22993679.
- ↑ Noiles K, Vender R (2008). "Are all seborrheic keratoses benign? Review of the typical lesion and its variants". J Cutan Med Surg. 12 (5): 203–10. doi:10.2310/7750.2008.07096. PMID 18845088.
- ↑ Uva L, Miguel D, Pinheiro C, Freitas JP, Marques Gomes M, Filipe P (2012). "Cutaneous manifestations of systemic lupus erythematosus". Autoimmune Dis. 2012: 834291. doi:10.1155/2012/834291. PMC 3410306. PMID 22888407.
- ↑ Kamal R, Dahiya P, Puri A (January 2012). "Oral pyogenic granuloma: Various concepts of etiopathogenesis". J Oral Maxillofac Pathol. 16 (1): 79–82. doi:10.4103/0973-029X.92978. PMC 3303528. PMID 22434943.
- ↑ Guillou L, Fletcher CD (August 2000). "Benign lymphangioendothelioma (acquired progressive lymphangioma): a lesion not to be confused with well-differentiated angiosarcoma and patch stage Kaposi's sarcoma: clinicopathologic analysis of a series". Am. J. Surg. Pathol. 24 (8): 1047–57. PMID 10935645.
- ↑ Goldberg RE, Pheasant TR, Shields JA (December 1979). "Cavernous hemangioma of the retina. A four-generation pedigree with neurocutaneous manifestations and an example of bilateral retinal involvement". Arch. Ophthalmol. 97 (12): 2321–4. PMID 229814.
