Kaposi's sarcoma differential diagnosis: Difference between revisions
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| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | Lobular vascular proliferations of vessels lined by plump endothelial cells | | style="background:#F5F5F5;" align="center" | Lobular vascular proliferations of vessels lined by plump endothelial cells | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Clinical manifestation | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | | ||
*Psychiatric disorders | *Psychiatric disorders | ||
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|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Arteriovenous malformation]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Arteriovenous malformation]] | ||
| style="background:#F5F5F5;" align="left" | | | style="background:#F5F5F5;" align="left" |Idiopathic | ||
* | * | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | + | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Any age | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | + | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | | ||
| style="background:#F5F5F5;" align="center" | | * Headache | ||
| style="background:#F5F5F5;" align="center" | | * Neurologic deficits | ||
| style="background:#F5F5F5;" align="center" | | * Heart failure | ||
| style="background:#F5F5F5;" align="center" | | * Macrocephaly | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" |Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | Nl | |||
| style="background:#F5F5F5;" align="center" | N/A | |||
| style="background:#F5F5F5;" align="center" | Imaging | |||
| style="background:#F5F5F5;" align="center" | | |||
* Hereditary hemorrhagic telangiectasia | |||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Acroangiodermatitis | | style="background: #DCDCDC; padding: 5px; text-align: center;" |Acroangiodermatitis | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Idioathic | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | More frequent in male, any ages | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Purplish-blue to brown papules and plaques | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" |Hyperkeratosis, parakeratosis, acanthosis, and mild spongiosis | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Clinical manifesttations | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | | ||
* Amputees, | |||
* Haemodialysis (HD) patients with arteriovenous (AV) shunts | |||
* Paralysed legs | |||
* Hepatitis C | |||
* Chronic venous insufficiency | |||
* AV malformations | |||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" | [[Angiosarcoma]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" | [[Angiosarcoma]] | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Idiopathic | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | More frequent in males, usually in adults | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" |Enlarging bruise, a blue-black nodule, or an unhealed ulceration | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | ↓ | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | ↓ | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | | ||
| style="background:#F5F5F5;" align="center" | | * Intercellular and intracellular lumina with or without red cells | ||
| style="background:#F5F5F5;" align="center" | | * Intermediate filaments and pinocytotic vesiclesin cytoplasm | ||
* Weibel-Palade bodies | |||
| style="background:#F5F5F5;" align="center" | Biopsy | |||
| style="background:#F5F5F5;" align="center" | - | |||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Masson's [[hemangioma]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |Masson's [[hemangioma]] | ||
| style="background:#F5F5F5;" align="center" | Idiopathic | |||
| style="background:#F5F5F5;" align="center" | - | |||
| style="background:#F5F5F5;" align="center" | - | |||
| style="background:#F5F5F5;" align="center" | N/A | |||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Papillary fronds lined by proliferating endothelium | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Clinical manifestations and histological findings | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | | ||
* HemangiomaS | |||
* Pyogenic granulomas | |||
* Lymphagiomas | |||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Seborrheic keratosis]] | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Seborrheic keratosis]] | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Clonal expansion of a mutated epidermal keratinocyte | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | + | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Any age | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | | ||
| style="background:#F5F5F5;" align="center" | | * Usually asymptomatic | ||
| style="background:#F5F5F5;" align="center" | | * Being stuck on the skin surface | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Papillomatous epithelial proliferation containing horn cysts | ||
| style="background:#F5F5F5;" align="center" | Clinical manifestations | |||
| style="background:#F5F5F5;" align="center" | | |||
* Dermatosis papulosa nigra | |||
* Stucco keratosis | |||
* Melanoacanthoma | |||
* Polypoid lesions | |||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Systemic lupus erythematosus]] ([[SLE]]) | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Systemic lupus erythematosus]] ([[SLE]]) | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | Idiopathic | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | More coomon in female, typically in the 20 to 30 years | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | | ||
| style="background:#F5F5F5;" align="center" | | * Erythema on the nasolabial folds | ||
| style="background:#F5F5F5;" align="center" | | * Macular or diffusely erythematous in sun-exposed areas (photosensitive rash) | ||
| style="background:#F5F5F5;" align="center" | | * Discoid rash | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | +/- | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | - | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | ↑ | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | +/- | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | +/- | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | | ||
| style="background:#F5F5F5;" align="center" | | * Weight loss | ||
| style="background:#F5F5F5;" align="center" | | |||
| style="background:#F5F5F5;" align="center" | | * Headache | ||
| style="background:#F5F5F5;" align="center" | | * Arthralgia | ||
| style="background:#F5F5F5;" align="center" | | * Myalgia | ||
* Nausea and dyspepsia | |||
* Pleuritic chest pain | |||
* Dyspnea | |||
* Hematuria | |||
| style="background:#F5F5F5;" align="center" | ↑ | |||
| style="background:#F5F5F5;" align="center" | ↓ | |||
| style="background:#F5F5F5;" align="center" | ↓ | |||
| style="background:#F5F5F5;" align="center" | - | |||
| style="background:#F5F5F5;" align="center" | Nl | |||
| style="background:#F5F5F5;" align="center" | | |||
* Hyperkeratosis, epidermal atrophy, vacuolar interface dermatitis | |||
* Thickening of the basement membrane | |||
* Superficial, perivascular, and perifollicular mononuclear cell inflammatory infiltrate | |||
| style="background:#F5F5F5;" align="center" | Clinical manifestations | |||
| style="background:#F5F5F5;" align="center" | | |||
* Raynaud phenomenon | |||
* Neuropsychiatric symptoms | |||
* Pleural effusion | |||
* Peptic ulcer diseas | |||
* Pericarditis | |||
* Myocarditis | |||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Pigmented purpuric dermatosis | | style="background: #DCDCDC; padding: 5px; text-align: center;" |Pigmented purpuric dermatosis |
Revision as of 19:17, 27 September 2018
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2] Haytham Allaham, M.D. [3]
Kaposi's sarcoma Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Kaposi's sarcoma differential diagnosis On the Web |
American Roentgen Ray Society Images of Kaposi's sarcoma differential diagnosis |
Risk calculators and risk factors for Kaposi's sarcoma differential diagnosis |
Overview
Kaposi's sarcoma must be differentiated from other diseases that cause similar cutaneous, pulmonary, and gastrointestinal involvement, such as bacillary angiomatosis, AIDS-related lymphoma, and seborrheic keratosis.[1][2][3]
Differentiating Kaposi's Sarcoma from other Diseases
- Kaposi's sarcoma must be differentiated from other diseases that cause similar cutaneous, pulmonary, and gastrointestinal involvement, such as:[1][2][3]
- Kaposi's sarcoma cutaneous lesions must be differentiated from:
- Bacillary angiomatosis
- Arteriovenous malformation
- Acroangiodermatitis
- Masson's hemangioma
- Angiosarcoma
- Seborrheic keratosis
- Erythematous lupus
- Pigmented purpuric dermatosis
- Pyogenic granuloma
- Benign lymphangioendothelioma
- Cavernous hemangioma
- Sarcomatoid carcinoma
- Spindle cell hemangioendothelioma
- Kaposi's sarcoma pulmonary lesions must be differentiated from:
- AIDS-related lymphoma
- Atypical pneumonia
- Fungal or mycobacterial infection
- Lung cancer
- Kaposi's sarcoma gastrointestinal lesions must be differentiated from:
Diseases | Etiology | Congenital | Acquied | Demography | Clinical manifestations | Lab findings | Gold standard diagnosis | Additional findings | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Symptoms | Signs | CBC | LFT | ESR/CRP | Histopathology | ||||||||||||||
Appearance | Fever | Bleeding | BP | Hepatosplenomegaly | Lymphadenopathy | Other | WBC | Hb | Plt | ||||||||||
Bacillary angiomatosis |
|
- | + | Any age, usually in 20-50 years | Solitary or multiple red, purple, flesh-colored, or colorless papules | +/- | +/- | Nl | - | - |
|
Nl | Nl | Nl | Nl | Nl | Lobular vascular proliferations of vessels lined by plump endothelial cells | Clinical manifestation |
|
Arteriovenous malformation | Idiopathic
|
+ | - | Any age | Nl | - | + | Nl | - | - |
|
Nl | Nl | Nl | Nl | Nl | N/A | Imaging |
|
Acroangiodermatitis | Idioathic | - | - | More frequent in male, any ages | Purplish-blue to brown papules and plaques | - | - | Nl | - | - | - | Nl | Nl | Nl | Nl | Nl | Hyperkeratosis, parakeratosis, acanthosis, and mild spongiosis | Clinical manifesttations |
|
Angiosarcoma | Idiopathic | - | - | More frequent in males, usually in adults | Enlarging bruise, a blue-black nodule, or an unhealed ulceration | - | - | Nl | - | - | - | Nl | ↓ | ↓ | Nl | Nl |
|
Biopsy | - |
Masson's hemangioma | Idiopathic | - | - | N/A | - | - | Nl | - | - | - | Nl | Nl | Nl | Nl | Nl | Papillary fronds lined by proliferating endothelium | Clinical manifestations and histological findings |
| |
Seborrheic keratosis | Clonal expansion of a mutated epidermal keratinocyte | + | - | Any age |
|
- | - | Nl | - | - | - | Nl | Nl | Nl | Nl | Nl | Papillomatous epithelial proliferation containing horn cysts | Clinical manifestations |
|
Systemic lupus erythematosus (SLE) | Idiopathic | - | - | More coomon in female, typically in the 20 to 30 years |
|
+/- | - | ↑ | +/- | +/- |
|
↑ | ↓ | ↓ | - | Nl |
|
Clinical manifestations |
|
Pigmented purpuric dermatosis | |||||||||||||||||||
Pyogenic granuloma |
|
+ | + | Any age, usually in 20-30 years | Painless red lesion (lobular capillary hemangioma) | - | + | Nl | - | - | - | Nl | Nl | Nl | Nl | Nl | Neutrophilic infiltration, hemorrhage, necrosis of the overlying epidermis | ||
Benign lymphangioendothelioma | |||||||||||||||||||
Cavernous hemangioma | |||||||||||||||||||
Sarcomatoid carcinoma | |||||||||||||||||||
Spindle cell hemangioendothelioma |
References
- ↑ 1.0 1.1 Kaposi's Sarcoma. Radiopaedia (2015) http://radiopaedia.org/articles/kaposi-sarcoma Accessed on January, 19 2016
- ↑ 2.0 2.1 Libre Pathology. Kaposi's sarcoma (2015) http://librepathology.org/wiki/index.php/File:Kaposi_sarcoma_low_intermed_mag.jpg Accessed on January, 19 2016
- ↑ 3.0 3.1 Kaposi's Sarcoma. PathologyOutlines (2015) http://www.pathologyoutlines.com/topic/skintumornonmelanocytickaposisarcoma.html Accessed on January, 19 2015