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{{Kaposi's sarcoma}}
{{Kaposi's sarcoma}}
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==Overview==
Kaposi's sarcoma is caused by [[coinfection]] with [[HIV]] and [[HHV-8]].


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==Overview==
Having [[AIDs]] can predispose the body to Kaposi's sarcoma. The weakening of the [[immune system]] plays a role in the development of various [[lesions]] including Kaposi's sarcoma.
==Causes==
==Causes==
===AIDS as a Cause of Kaposi's Sarcoma===
* Kaposi's sarcoma is caused by an [[infection]] with [[HHV-8]].<ref name="pmid23806158">{{cite journal| author=Ruocco E, Ruocco V, Tornesello ML, Gambardella A, Wolf R, Buonaguro FM| title=Kaposi's sarcoma: etiology and pathogenesis, inducing factors, causal associations, and treatments: facts and controversies. | journal=Clin Dermatol | year= 2013 | volume= 31 | issue= 4 | pages= 413-22 | pmid=23806158 | doi=10.1016/j.clindermatol.2013.01.008 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23806158  }} </ref>
In AIDS patients, Kaposi's sarcoma is considered an [[opportunistic infection]], i.e., a disease that is able to gain a foothold in the body because the [[immune system]] has been weakened. With the rise of AIDS in Africa, where KSHV is widespread, KS has become the most frequently reported cancer in some countries, such as Zimbabwe.
* The term Kaposi's sarcoma associated virus(KHSV) was coined in order to name the [[viral]] causes.<ref name="pmid21377267">{{cite journal |vauthors=Uldrick TS, Whitby D |title=Update on KSHV epidemiology, Kaposi Sarcoma pathogenesis, and treatment of Kaposi Sarcoma |journal=Cancer Lett. |volume=305 |issue=2 |pages=150–62 |date=June 2011 |pmid=21377267 |pmc=3085592 |doi=10.1016/j.canlet.2011.02.006 |url=}}</ref><ref name="pmid7997879">{{cite journal |vauthors=Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS |title=Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma |journal=Science |volume=266 |issue=5192 |pages=1865–9 |date=December 1994 |pmid=7997879 |doi= |url=}}</ref>
 
Because of their highly visible nature, external lesions are sometimes the presenting symptom of AIDS. Kaposi's sarcoma entered the awareness of the general public with the release of the film Philadelphia, in which the main character was fired after his employers found out he was HIV-positive due to visible lesions. Unfortunately, by the time KS lesions appear, it is likely that the immune system has already been severely weakened.


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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Latest revision as of 12:04, 11 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Kaposi's sarcoma is caused by coinfection with HIV and HHV-8.

Causes

  • Kaposi's sarcoma is caused by an infection with HHV-8.[1]
  • The term Kaposi's sarcoma associated virus(KHSV) was coined in order to name the viral causes.[2][3]

References

  1. Ruocco E, Ruocco V, Tornesello ML, Gambardella A, Wolf R, Buonaguro FM (2013). "Kaposi's sarcoma: etiology and pathogenesis, inducing factors, causal associations, and treatments: facts and controversies". Clin Dermatol. 31 (4): 413–22. doi:10.1016/j.clindermatol.2013.01.008. PMID 23806158.
  2. Uldrick TS, Whitby D (June 2011). "Update on KSHV epidemiology, Kaposi Sarcoma pathogenesis, and treatment of Kaposi Sarcoma". Cancer Lett. 305 (2): 150–62. doi:10.1016/j.canlet.2011.02.006. PMC 3085592. PMID 21377267.
  3. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS (December 1994). "Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma". Science. 266 (5192): 1865–9. PMID 7997879.


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