Idiopathic interstitial pneumonia natural history, complications and prognosis: Difference between revisions

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==Major Idiopathic Interstitial Pneumonias==
==Major Idiopathic Interstitial Pneumonias==


* '''Chronic fibrosing IIPs''':
====Chronic Fibrosing IIPs====
:* '''[[Idiopathic pulmonary fibrosis]]'''
=====Idiopathic Pulmonary Fibrosis=====
::* The most common and the worst prognosis of chronic IIPs.  
::* The most common and the worst prognosis of chronic IIPs.  


Revision as of 17:26, 18 November 2013

Idiopathic Interstitial Pneumonia Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]

Overview

Natural history and Complications

Major Idiopathic Interstitial Pneumonias

Chronic Fibrosing IIPs

Idiopathic Pulmonary Fibrosis
  • The most common and the worst prognosis of chronic IIPs.
  • Better outcome than IPF.
  • Cellular type is more common than Fibrotic type.
  • The cellular NSIP is better than fibrosing type of NSIP.
  • Larger studies are needed to understand the clinical course of NSIP, however smaller studies showed that the 10-Yr survival of fibrotic NSIP is 35%,[1] 5-Yr survival rate is 43%, [2] 25% deterioration of lung function despite treatment.[3]


  • Acute/Subacute IIPs:
  • Smoking-related IIPs:

Rare Idiopathic Interstitial Pneumonias

  • Idiopathic lymphoid interstitial pneumonia
  • Idiopathic pleuroparenchymal fibroelastosis

Biomarkers

The functional lung capacity, pulmonary functions and mortality have been linked to some biomarkers. For example some studies showed that rapidly deteriorating lung function and higher mortality have been associated with high serum level of epithelial or macrophage-related proteins such as SP-A, SP-D, KL-6 (Krebs von den Lungen-6), CCL18 (chemokine ligand-18), and MMP-7 (matrix metalloproteinase-7) [4] [5] [6]

References

  1. ↑ Travis, WD.; Matsui, K.; Moss, J.; Ferrans, VJ. (2000). "Idiopathic nonspecific interstitial pneumonia: prognostic significance of cellular and fibrosing patterns: survival comparison with usual interstitial pneumonia and desquamative interstitial pneumonia". Am J Surg Pathol. 24 (1): 19–33. PMID 10632484. Unknown parameter |month= ignored (help)
  2. ↑ Nicholson, AG.; Colby, TV.; du Bois, RM.; Hansell, DM.; Wells, AU. (2000). "The prognostic significance of the histologic pattern of interstitial pneumonia in patients presenting with the clinical entity of cryptogenic fibrosing alveolitis". Am J Respir Crit Care Med. 162 (6): 2213–7. doi:10.1164/ajrccm.162.6.2003049. PMID 11112140. Unknown parameter |month= ignored (help)
  3. ↑ Kondoh, Y.; Taniguchi, H.; Yokoi, T.; Nishiyama, O.; Ohishi, T.; Kato, T.; Suzuki, K.; Suzuki, R. (2005). "Cyclophosphamide and low-dose prednisolone in idiopathic pulmonary fibrosis and fibrosing nonspecific interstitial pneumonia". Eur Respir J. 25 (3): 528–33. doi:10.1183/09031936.05.00071004. PMID 15738299. Unknown parameter |month= ignored (help)
  4. ↑ Satoh, H.; Kurishima, K.; Ishikawa, H.; Ohtsuka, M. (2006). "Increased levels of KL-6 and subsequent mortality in patients with interstitial lung diseases". J Intern Med. 260 (5): 429–34. doi:10.1111/j.1365-2796.2006.01704.x. PMID 17040248. Unknown parameter |month= ignored (help)
  5. ↑ Prasse, A.; Probst, C.; Bargagli, E.; Zissel, G.; Toews, GB.; Flaherty, KR.; Olschewski, M.; Rottoli, P.; Müller-Quernheim, J. (2009). "Serum CC-chemokine ligand 18 concentration predicts outcome in idiopathic pulmonary fibrosis". Am J Respir Crit Care Med. 179 (8): 717–23. doi:10.1164/rccm.200808-1201OC. PMID 19179488. Unknown parameter |month= ignored (help)
  6. ↑ Ishii, H.; Mukae, H.; Kadota, J.; Kaida, H.; Nagata, T.; Abe, K.; Matsukura, S.; Kohno, S. (2003). "High serum concentrations of surfactant protein A in usual interstitial pneumonia compared with non-specific interstitial pneumonia". Thorax. 58 (1): 52–7. PMID 12511721. Unknown parameter |month= ignored (help)

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