Hypopharyngeal cancer medical therapy: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Hypopharyngeal cancer}} | {{Hypopharyngeal cancer}} | ||
{{CMG}} {{AE}}{{Faizan}} | {{CMG}}; {{AE}} {{G.D.}}, {{Faizan}} | ||
==Overview== | ==Overview== | ||
The [[medical]] [[therapy]] with the combination of the [[radiotherapy]] has been used compared to [[Surgery|surgical]] [[therapy]] for the treatment of hypopharyngeal cancer.The optimal [[therapy]] for hypopharyngeal cancer depends on the stage at the time of the [[diagnosis]]. The combined treatment helps with [[Organ (anatomy)|organ]] preservation. [[Swallowing]], [[speech]] and [[laryngeal]] preservation are important to consider during the treatment. | |||
==Medical Therapy== | |||
* The [[medical]] [[therapy]] with [[radiotherapy]] has been used compared to surgical [[therapy]] for the treatment of hypopharyngeal cancer due to [[Organ (anatomy)|organ]] preservation.<ref name="pmid19306746">{{cite journal |vauthors=Lefebvre JL, Ang KK |title=Larynx preservation clinical trial design: key issues and recommendations-a consensus panel summary |journal=Int. J. Radiat. Oncol. Biol. Phys. |volume=73 |issue=5 |pages=1293–303 |date=April 2009 |pmid=19306746 |doi=10.1016/j.ijrobp.2008.10.047 |url=}}</ref><ref name="pmid8656441">{{cite journal |vauthors=Lefebvre JL, Chevalier D, Luboinski B, Kirkpatrick A, Collette L, Sahmoud T |title=Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group |journal=J. Natl. Cancer Inst. |volume=88 |issue=13 |pages=890–9 |date=July 1996 |pmid=8656441 |doi= |url=}}</ref> | |||
* The optimal [[therapy]] for hypopharyngeal cancer depends on the stage at the time of [[diagnosis]]. The following factors are important to consider: | |||
**[[Swallowing]] | |||
**[[Speech]] | |||
**[[Larynx]] | |||
==Chemotherapy== | |||
*[[Chemotherapy]] followed by [[radiation therapy]] may help in [[Organ (anatomy)|organ]] preservation.<ref name="urlHypopharyngeal Cancer Treatment (PDQ®)—Health Professional Version - National Cancer Institute">{{cite web |url=https://www.cancer.gov/types/head-and-neck/hp/adult/hypopharyngeal-treatment-pdq#section/_74 |title=Hypopharyngeal Cancer Treatment (PDQ®)—Health Professional Version - National Cancer Institute |format= |work= |accessdate=}}</ref> | |||
*[[Cisplatin]] plus [[Fluorouracil|Fluorouraci]]<nowiki/>l followed by [[radiation therapy]] are used for advanced stage. | |||
==Radiation Therapy== | |||
*[[Radiation therapy]] may be used as a single modality treatment in early lesions.<ref name="Wei2002">{{cite journal|last1=Wei|first1=William I.|title=The Dilemma of Treating Hypopharyngeal Carcinoma: More or Less|journal=Archives of Otolaryngology–Head & Neck Surgery|volume=128|issue=3|year=2002|pages=229|issn=0886-4470|doi=10.1001/archotol.128.3.229}}</ref> | |||
*[[Laser surgery]] is gradually replacing [[radiotherapy]] for early lesions as the outcome of both are similar while the [[laser therapy]]. | |||
Chemotherapy | |||
Treatment | |||
Treatment | |||
* | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category: | [[Category:Gastroenterology]] | ||
[[Category:Otolaryngology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 17:18, 1 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Faizan Sheraz, M.D. [3]
Overview
The medical therapy with the combination of the radiotherapy has been used compared to surgical therapy for the treatment of hypopharyngeal cancer.The optimal therapy for hypopharyngeal cancer depends on the stage at the time of the diagnosis. The combined treatment helps with organ preservation. Swallowing, speech and laryngeal preservation are important to consider during the treatment.
Medical Therapy
- The medical therapy with radiotherapy has been used compared to surgical therapy for the treatment of hypopharyngeal cancer due to organ preservation.[1][2]
- The optimal therapy for hypopharyngeal cancer depends on the stage at the time of diagnosis. The following factors are important to consider:
Chemotherapy
- Chemotherapy followed by radiation therapy may help in organ preservation.[3]
- Cisplatin plus Fluorouracil followed by radiation therapy are used for advanced stage.
Radiation Therapy
- Radiation therapy may be used as a single modality treatment in early lesions.[4]
- Laser surgery is gradually replacing radiotherapy for early lesions as the outcome of both are similar while the laser therapy.
References
- ↑ Lefebvre JL, Ang KK (April 2009). "Larynx preservation clinical trial design: key issues and recommendations-a consensus panel summary". Int. J. Radiat. Oncol. Biol. Phys. 73 (5): 1293–303. doi:10.1016/j.ijrobp.2008.10.047. PMID 19306746.
- ↑ Lefebvre JL, Chevalier D, Luboinski B, Kirkpatrick A, Collette L, Sahmoud T (July 1996). "Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group". J. Natl. Cancer Inst. 88 (13): 890–9. PMID 8656441.
- ↑ "Hypopharyngeal Cancer Treatment (PDQ®)—Health Professional Version - National Cancer Institute".
- ↑ Wei, William I. (2002). "The Dilemma of Treating Hypopharyngeal Carcinoma: More or Less". Archives of Otolaryngology–Head & Neck Surgery. 128 (3): 229. doi:10.1001/archotol.128.3.229. ISSN 0886-4470.