Hypopharyngeal cancer medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Faizan Sheraz, M.D. [3]
Overview
The medical therapy with the combination of the radiotherapy has been used compared to surgical therapy for the treatment of hypopharyngeal cancer.The optimal therapy for hypopharyngeal cancer depends on the stage at the time of the diagnosis. The combined treatment helps with organ preservation. Swallowing, speech and laryngeal preservation are important to consider during the treatment.
Medical Therapy
- The medical therapy with radiotherapy has been used compared to surgical therapy for the treatment of hypopharyngeal cancer due to organ preservation.[1][2]
- The optimal therapy for hypopharyngeal cancer depends on the stage at the time of diagnosis. The following factors are important to consider:
Chemotherapy
- Chemotherapy followed by radiation therapy may help in organ preservation.[3]
- Cisplatin plus Fluorouracil followed by radiation therapy are used for advanced stage.
Radiation Therapy
- Radiation therapy may be used as a single modality treatment in early lesions.[4]
- Laser surgery is gradually replacing radiotherapy for early lesions as the outcome of both are similar while the laser therapy.
References
- ↑ Lefebvre JL, Ang KK (April 2009). "Larynx preservation clinical trial design: key issues and recommendations-a consensus panel summary". Int. J. Radiat. Oncol. Biol. Phys. 73 (5): 1293–303. doi:10.1016/j.ijrobp.2008.10.047. PMID 19306746.
- ↑ Lefebvre JL, Chevalier D, Luboinski B, Kirkpatrick A, Collette L, Sahmoud T (July 1996). "Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group". J. Natl. Cancer Inst. 88 (13): 890–9. PMID 8656441.
- ↑ "Hypopharyngeal Cancer Treatment (PDQ®)—Health Professional Version - National Cancer Institute".
- ↑ Wei, William I. (2002). "The Dilemma of Treating Hypopharyngeal Carcinoma: More or Less". Archives of Otolaryngology–Head & Neck Surgery. 128 (3): 229. doi:10.1001/archotol.128.3.229. ISSN 0886-4470.