Hygromycin B

	WikiDoc Resources for Hygromycin B
Articles
Most recent articles on Hygromycin B Most cited articles on Hygromycin B Review articles on Hygromycin B Articles on Hygromycin B in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Hygromycin B Images of Hygromycin B Photos of Hygromycin B Podcasts & MP3s on Hygromycin B Videos on Hygromycin B
Evidence Based Medicine
Cochrane Collaboration on Hygromycin B Bandolier on Hygromycin B TRIP on Hygromycin B
Clinical Trials
Ongoing Trials on Hygromycin B at Clinical Trials.gov Trial results on Hygromycin B Clinical Trials on Hygromycin B at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Hygromycin B NICE Guidance on Hygromycin B NHS PRODIGY Guidance FDA on Hygromycin B CDC on Hygromycin B
Books
Books on Hygromycin B
News
Hygromycin B in the news Be alerted to news on Hygromycin B News trends on Hygromycin B
Commentary
Blogs on Hygromycin B
Definitions
Definitions of Hygromycin B
Patient Resources / Community
Patient resources on Hygromycin B Discussion groups on Hygromycin B Patient Handouts on Hygromycin B Directions to Hospitals Treating Hygromycin B Risk calculators and risk factors for Hygromycin B
Healthcare Provider Resources
Symptoms of Hygromycin B Causes & Risk Factors for Hygromycin B Diagnostic studies for Hygromycin B Treatment of Hygromycin B
Continuing Medical Education (CME)
CME Programs on Hygromycin B
International
Hygromycin B en Espanol Hygromycin B en Francais
Business
Hygromycin B in the Marketplace Patents on Hygromycin B
Experimental / Informatics
List of terms related to Hygromycin B

Hygromycin B
	File:Hygromycin B.png
Identifiers
	IUPAC name O-6-Amino-6-deoxy-L-glycero- D-galacto- heptopyranosylidene- (1-2-3)-O-beta-D-talopyranosyl (1-5) -2-deoxy-N3-methyl-D-streptamine;
CAS Number	31282-04-9;
PubChem CID	35766;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C20H37N3O13
Molar mass	527.53 g/mol (563.5 with HCl)

The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

Hygromycin B, is an antibiotic produced by the bacterium Streptomyces hygroscopicus. It is an aminoglycoside that kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis^[1].

History

Hygromycin B was originally developed in the 1950's for use with animals and is still added into swine and chicken feed as an anthelmintic or anti-worming agent (product name: Hygromix). Hygromycin B is produced by Streptomyces hygroscopicus, a bacteria isolated in 1953 from a soil sample. Resistance genes were discovered in the early 1980's.^[2]^[3]

Use in research

In the laboratory it is used for the selection and maintenance of prokaryotic and eukaryotic cells that contain the hygromycin resistance gene. The resistance gene is a kinase that inactivates hygromycin B through phosphorylation.^[4] Since the discovery of hygromycin-resistance genes, hygromycin B has become a standard selection antibiotic in gene transfer experiments in many prokaryotic and eukaryotic cells.

External links

Information from hygromycin.net (InvivoGen)

mechanism of action: [1]
resistance genes: [2]
chemistry, stability: [3]

References

↑ McGuire, Pettinger (1953), "Hygromycin I. Preliminary studies on the production and biological activity of a new antibiotic.", Antibiot. Chemother., 3: 1268–1278
↑ Davies, Gritz (1983), "Plasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae.", Gene, 25: 179–88
↑ Burgett, Kaster (1983), "Analysis of a bacterial hygromycin B resistance gene by transcriptional and translational fusions and by DNA sequencing.", Nucleic Acids Res., 11: 6895–911
↑ Rao RN, Allen NE, Hobbs JN, Alborn WE, Kirst HA, Paschal JW (1983). "Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli". Antimicrobial Agents and Chemotherapy. 24 (5): 689–95. PMID 6318654.

Template:WH Template:WikiDoc Sources

[discovery-1] McGuire, Pettinger (1953), "Hygromycin I. Preliminary studies on the production and biological activity of a new antibiotic.", Antibiot. Chemother., 3: 1268–1278

[res1-2] Davies, Gritz (1983), "Plasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae.", Gene, 25: 179–88

[res2-3] Burgett, Kaster (1983), "Analysis of a bacterial hygromycin B resistance gene by transcriptional and translational fusions and by DNA sequencing.", Nucleic Acids Res., 11: 6895–911

[pmid6318654-4] Rao RN, Allen NE, Hobbs JN, Alborn WE, Kirst HA, Paschal JW (1983). "Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli". Antimicrobial Agents and Chemotherapy. 24 (5): 689–95. PMID 6318654.

[1]

[2]

[3]

[4]

Hygromycin B

Contents

History

Use in research

External links

References

Navigation menu

Identifiers
File:Hygromycin B.png
IUPAC name O-6-Amino-6-deoxy-L-glycero- D-galacto- heptopyranosylidene- (1-2-3)-O-beta-D-talopyranosyl (1-5) -2-deoxy-N3-methyl-D-streptamine
CAS Number	31282-04-9
PubChem CID	35766
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₀H₃₇N₃O₁₃
Molar mass	527.53 g/mol (563.5 with HCl)