Hygromycin B

Jump to: navigation, search
Hygromycin B
220px
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC20H37N3O13
Molar mass527.53 g/mol (563.5 with HCl)

WikiDoc Resources for Hygromycin B

Articles

Most recent articles on Hygromycin B

Most cited articles on Hygromycin B

Review articles on Hygromycin B

Articles on Hygromycin B in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Hygromycin B

Images of Hygromycin B

Photos of Hygromycin B

Podcasts & MP3s on Hygromycin B

Videos on Hygromycin B

Evidence Based Medicine

Cochrane Collaboration on Hygromycin B

Bandolier on Hygromycin B

TRIP on Hygromycin B

Clinical Trials

Ongoing Trials on Hygromycin B at Clinical Trials.gov

Trial results on Hygromycin B

Clinical Trials on Hygromycin B at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Hygromycin B

NICE Guidance on Hygromycin B

NHS PRODIGY Guidance

FDA on Hygromycin B

CDC on Hygromycin B

Books

Books on Hygromycin B

News

Hygromycin B in the news

Be alerted to news on Hygromycin B

News trends on Hygromycin B

Commentary

Blogs on Hygromycin B

Definitions

Definitions of Hygromycin B

Patient Resources / Community

Patient resources on Hygromycin B

Discussion groups on Hygromycin B

Patient Handouts on Hygromycin B

Directions to Hospitals Treating Hygromycin B

Risk calculators and risk factors for Hygromycin B

Healthcare Provider Resources

Symptoms of Hygromycin B

Causes & Risk Factors for Hygromycin B

Diagnostic studies for Hygromycin B

Treatment of Hygromycin B

Continuing Medical Education (CME)

CME Programs on Hygromycin B

International

Hygromycin B en Espanol

Hygromycin B en Francais

Business

Hygromycin B in the Marketplace

Patents on Hygromycin B

Experimental / Informatics

List of terms related to Hygromycin B


Hygromycin B, is an antibiotic produced by the bacterium Streptomyces hygroscopicus. It is an aminoglycoside that kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis[1].

History

Hygromycin B was originally developed in the 1950's for use with animals and is still added into swine and chicken feed as an anthelmintic or anti-worming agent (product name: Hygromix). Hygromycin B is produced by Streptomyces hygroscopicus, a bacteria isolated in 1953 from a soil sample. Resistance genes were discovered in the early 1980's.[2][3]

Use in research

In the laboratory it is used for the selection and maintenance of prokaryotic and eukaryotic cells that contain the hygromycin resistance gene. The resistance gene is a kinase that inactivates hygromycin B through phosphorylation.[4] Since the discovery of hygromycin-resistance genes, hygromycin B has become a standard selection antibiotic in gene transfer experiments in many prokaryotic and eukaryotic cells.

External links

Information from hygromycin.net (InvivoGen)

  • mechanism of action: [1]
  • resistance genes: [2]
  • chemistry, stability: [3]

References

  1. McGuire, Pettinger (1953), "Hygromycin I. Preliminary studies on the production and biological activity of a new antibiotic.", Antibiot. Chemother., 3: 1268–1278
  2. Davies, Gritz (1983), "Plasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae.", Gene, 25: 179–88
  3. Burgett, Kaster (1983), "Analysis of a bacterial hygromycin B resistance gene by transcriptional and translational fusions and by DNA sequencing.", Nucleic Acids Res., 11: 6895–911
  4. Rao RN, Allen NE, Hobbs JN, Alborn WE, Kirst HA, Paschal JW (1983). "Genetic and enzymatic basis of hygromycin B resistance in Escherichia coli". Antimicrobial Agents and Chemotherapy. 24 (5): 689–95. PMID 6318654.



Linked-in.jpg