Hodgkin's lymphoma pathophysiology: Difference between revisions

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| style="padding: 5px 5px; background: #DCDCDC;" colspan=3 | '''Variants'''
| style="padding: 5px 5px; background: #DCDCDC;" colspan=3 | '''Variants'''
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| style="padding: 5px 5px; background: #F5F5F5;" | Hodgkin cell
| style="padding: 5px 5px; background: #F5F5F5;" | Hodgkin cells
| style="padding: 5px 5px; background: #F5F5F5;" | (Atypical mononuclear Reed-Sternberg cell)  has the same characteristics as Reed-Sternberg cells (RSC), but is mononucleated.
| style="padding: 5px 5px; background: #F5F5F5;" | (Atypical mononuclear Reed-Sternberg cell)  have the same characteristics as Reed-Sternberg cells (RSC), but is mononucleated.
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| style="padding: 5px 5px; background: #F5F5F5;" | Lacunar Reed-Sternberg cells  
| style="padding: 5px 5px; background: #F5F5F5;" | Lacunar Reed-Sternberg cells  

Revision as of 17:12, 8 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Pathophysiology

Hodgkin's lymphoma,[1] also known as Hodgkin lymphoma or Hodgkin's disease,[2] is a type of lymphoma, in which cancer originates from a specific type of white blood cells called lymphocytes.

Gross Pathology

Affected lymph nodes (most often, laterocervical lymph nodes) are enlarged, but their shape is preserved because the capsule is not invaded. Usually, the cut surface is white-grey and uniform; in some histological subtypes (e.g. nodular sclerosis) may appear a nodular aspect

Microscopic Pathology

Microscopic examination of the lymph node biopsy reveals complete or partial effacement of the lymph node architecture by scattered large malignant cells known as Reed-Sternberg cells (typical and variants) admixed within a reactive cell infiltrate composed of variable proportions of lymphocytes, histiocytes, eosinophils, and plasma cells. The Reed-Sternberg cells are identified as large often bi-nucleated cells with prominent nucleoli and an unusual CD45-, CD30+, CD15+/- immunophenotype. In approximately 50% of cases, the Reed-Sternberg cells are infected by the Epstein-Barr virus.



Reed-Sternberg cells (RSC) (Classical and variants)
Type of cell Characteristics
Classic
Reed-Sternberg cells (RSC) Include large size (20–50 micrometres), abundant, amphophilic, finely granular/homogeneous cytoplasm; two mirror-image nuclei (owl eyes) each with an eosinophilic nucleolus and a thick nuclear membrane (chromatin is distributed close to the nuclear membrane).
Variants
Hodgkin cells (Atypical mononuclear Reed-Sternberg cell) have the same characteristics as Reed-Sternberg cells (RSC), but is mononucleated.
Lacunar Reed-Sternberg cells Are large, with a single hyperlobulated nucleus, multiple, small nucleoli and eosinophilic cytoplasm which is retracted around the nucleus, creating an empty space ("lacunae").
Pleomorphic Reed-Sternberg cells Has multiple irregular nuclei.
"Popcorn" Reed-Sternberg cells (Lympho-histiocytic variant) is a small cell, with a very lobulated nucleus, small nucleoli.
"Mummy" Reed-Sternberg cells Has a compact nucleus with no nucleolus and basophilic cytoplasm.

References

  1. Scientific Style and Format: The CBE Manual for Authors, Editors, and Publishers. Cambridge University Press. 1994. pp. 97–. ISBN 978-0-521-47154-1.
  2. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. (Dec 15, 2012). "Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010". Lancet. 380 (9859): 2095–128. doi:10.1016/S0140-6736(12)61728-0. OCLC 23245604.
  3. http://picasaweb.google.com/mcmumbi/USMLEIIImages


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