Hodgkin's lymphoma medical therapy: Difference between revisions

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==Overview==
==Overview==
Patients with early stage disease (IA or IIA) are effectively treated with [[radiation]] therapy or chemotherapy. The choice of treatment depends on the age, sex, bulk and the histological subtype of the disease. Patients with later disease (III, IVA, or IVB) are treated with combination chemotherapy alone.  Patients of any stage with a large mass in the chest are usually treated with combined chemotherapy and radiation therapy.
The predominant therapy for Hodgkin's lymphoma is chemotherapy. Adjunctive radiation may be required.
==Medical Therapy==
The choice of treatment depends on the age, sex, bulk and the histological subtype of the disease.
* Patients with early stage disease (IA or IIA) are effectively treated with [[radiation]] therapy or chemotherapy.


==Medical Therapy==
* Patients with later disease (III, IVA, or IVB) are treated with combination chemotherapy alone.


* Patients of any stage with a large mass in the chest are usually treated with combined chemotherapy and radiation therapy.
===Chemotherapy===
===Chemotherapy===
* Drug Regimen: (MOPP) [[Mustargen]] {{and}} [[Oncovin]] {{and}} [[Prednisone]] {{and}} [[Procarbazine]]
* Drug Regimen: (MOPP) [[Mustargen]] {{and}} [[Oncovin]] {{and}} [[Prednisone]] {{and}} [[Procarbazine]]
* Drug Regimen: (''[[ABVD]]'') [[Adriamycin]] {{and}} [[Bleomycin]] {{and}} [[Vinblastine]] {{and}} [[Dacarbazine]]
* Drug Regimen: (''[[ABVD]]'') [[Adriamycin]] {{and}} [[Bleomycin]] {{and}} [[Vinblastine]] {{and}} [[Dacarbazine]]
* Drug Regimen: ([[Stanford V]]) [[Adriamycin]] {{and}}  [[Bleomycin]] {{and}} [[Vinblastine]] {{and}} [[Mechlorethamine]] {{and}} [[Etoposide]] {{and}} [[Prednisone]] {{and}} [[Radiation therapy]].
* Drug Regimen: ([[Stanford V]]) [[Adriamycin]] {{and}}  [[Bleomycin]] {{and}} [[Vinblastine]] {{and}} [[Mechlorethamine]] {{and}} [[Etoposide]] {{and}} [[Prednisone]] {{and}} [[Radiation therapy]].
* Drug Regimen: ([[BEACOPP]]) [[Bleomycin]] {{and}} [[Etoposide]] {{and}} [[Adriamycin]] {{and}} [[Cyclophosphamide]] {{and}} [[Oncovin]] {{and}} [[Procarbazine]] {{and}} [[Prednisone]]
* Drug Regimen: ([[BEACOPP]]) [[Bleomycin]] {{and}} [[Etoposide]] {{and}} [[Adriamycin]] {{and}} [[Cyclophosphamide]] {{and}} [[Oncovin]] {{and}} [[Procarbazine]] {{and}} [[Prednisone]]


With appropriate treatment, over 93% of Hodgkin's lymphoma cases are curable.
===Radiotherapy===
* Radiation oncologists deliver external beam radiation therapy to the lymphoma from a machine called  linear accelerator which produces high energy X Rays and Electrons. Patients usually describe treatments as painless and similar to getting an X-ray. Treatments last less than 30 minutes each.
* For lymphomas, there are a few different ways radiation oncologists target the cancer cells.
:* Involved field radiation is when the radiation oncologists give radiation only to those parts of the patient's body known to have the cancer. Very often, this is combined with chemotherapy.
:* Radiation therapy directed above the diaphragm to the neck, chest and/or underarms is called mantle field radiation.
:* Radiation to below the diaphragm to the abdomen, spleen and/or pelvis is called inverted-Y field radiation.
:* Total nodal irradiation is when the therapist gives radiation to all the lymph nodes in the body to destroy cells that may have spread.<ref>{{cite web|url=http://www.rtanswers.com/treatmentinformation/cancertypes/lymphomas/externalbeam.aspx |title=RTanswers.com |publisher=RTanswers.com |date=2010-12-03 |accessdate=2012-08-26}}</ref>


The high cure rates and long survival of many patients with Hodgkin's lymphoma has led to a high concern with late adverse effects of treatment, including cardiovascular disease and second malignancies such as acute [[leukemia]]s, lymphomas, and solid tumors within the radiation therapy field. Most patients with early stage disease are now treated with abbreviated chemotherapy and involved-field radiation therapy rather than with radiation therapy alone. Clinical research strategies are exploring reduction of the duration of chemotherapy and dose and volume of radiation therapy in an attempt to reduce late morbidity and mortality of treatment while maintaining high cure rates. Hospitals are also treating those who respond quickly to chemo-therapy with no radiation.


==References==
==References==

Revision as of 21:00, 8 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

The predominant therapy for Hodgkin's lymphoma is chemotherapy. Adjunctive radiation may be required.

Medical Therapy

The choice of treatment depends on the age, sex, bulk and the histological subtype of the disease.

  • Patients with early stage disease (IA or IIA) are effectively treated with radiation therapy or chemotherapy.
  • Patients with later disease (III, IVA, or IVB) are treated with combination chemotherapy alone.
  • Patients of any stage with a large mass in the chest are usually treated with combined chemotherapy and radiation therapy.

Chemotherapy

Radiotherapy

  • Radiation oncologists deliver external beam radiation therapy to the lymphoma from a machine called linear accelerator which produces high energy X Rays and Electrons. Patients usually describe treatments as painless and similar to getting an X-ray. Treatments last less than 30 minutes each.
  • For lymphomas, there are a few different ways radiation oncologists target the cancer cells.
  • Involved field radiation is when the radiation oncologists give radiation only to those parts of the patient's body known to have the cancer. Very often, this is combined with chemotherapy.
  • Radiation therapy directed above the diaphragm to the neck, chest and/or underarms is called mantle field radiation.
  • Radiation to below the diaphragm to the abdomen, spleen and/or pelvis is called inverted-Y field radiation.
  • Total nodal irradiation is when the therapist gives radiation to all the lymph nodes in the body to destroy cells that may have spread.[1]


References

  1. "RTanswers.com". RTanswers.com. 2010-12-03. Retrieved 2012-08-26.


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