Hamman-Rich syndrome laboratory findings: Difference between revisions
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Laboratory findings consistent with the diagnosis of acute interstitial pneumonitis include: | Laboratory findings consistent with the diagnosis of acute interstitial pneumonitis include: | ||
*Abnormal [[Arterial blood gas|ABG]] | *Abnormal [[Arterial blood gas|ABG]] | ||
**May indicate [[hypoxia]], [[hypercapnia]], and [[respiratory acidosis]] | **May indicate [[hypoxia]], [[hypercapnia]], and [[respiratory acidosis]]. | ||
*[[Spirometry]]<ref name="pmid15133338">{{cite journal |vauthors=Chetta A, Marangio E, Olivieri D |title=Pulmonary function testing in interstitial lung diseases |journal=Respiration |volume=71 |issue=3 |pages=209–13 |date=2004 |pmid=15133338 |doi=10.1159/000077416 |url=}}</ref> | *[[Spirometry]]<ref name="pmid15133338">{{cite journal |vauthors=Chetta A, Marangio E, Olivieri D |title=Pulmonary function testing in interstitial lung diseases |journal=Respiration |volume=71 |issue=3 |pages=209–13 |date=2004 |pmid=15133338 |doi=10.1159/000077416 |url=}}</ref> | ||
**May indicate a [[Restrictive Lung Disease|restrictive]] pulmonary disease | **May indicate a [[Restrictive Lung Disease|restrictive]] pulmonary disease. | ||
**A [[FEV1/FVC ratio]] > 80% indicates restrictive disease | **A [[FEV1/FVC ratio]] > 80% indicates restrictive disease. | ||
**[[Peak flow meter|Peak flow]] assessment | **[[Peak flow meter|Peak flow]] assessment | ||
***May be below normal range which is 100 liters/minute for men, and 80 liters/minute for women | ***May be below normal range which is 100 liters/minute for men, and 80 liters/minute for women. | ||
*[[Complete blood count|CBC]] | *[[Complete blood count|CBC]] | ||
**May indicate [[anemia]], [[neutrophilia]], elevated [[Erythrocyte sedimentation rate|ESR]], elevated [[C-reactive protein|CRP]], and elevated [[Antibody|immunoglobulin]] | **May indicate [[anemia]], [[neutrophilia]], elevated [[Erythrocyte sedimentation rate|ESR]], elevated [[C-reactive protein|CRP]], and elevated [[Antibody|immunoglobulin]]. | ||
*Microbiologic tests: | *Microbiologic tests: | ||
**Influenza testing using nasopharyngeal aspirates | **[[Influenza]] testing using nasopharyngeal aspirates | ||
**Serologic tests for atypical pneumonias (eg, Coccidioides, Chlamydia, coronavirus) | **Serologic tests for atypical pneumonias (eg, [[Coccidioides immitis|Coccidioides]], [[Chlamydia infection|Chlamydia]], coronavirus) | ||
**Urinary antigen tests for [[Streptococcus pneumoniae]] and [[Legionella]] | **Urinary antigen tests for [[Streptococcus pneumoniae]] and [[Legionella]] | ||
*Serologic tests for detection of [[Autoimmunity|autoimmune diseases]] | *Serologic tests for detection of [[Autoimmunity|autoimmune diseases]] | ||
*Abnormal [[sputum]] analysis | *Abnormal [[sputum]] analysis | ||
**May contain [[bacteria]], such as [[mycobacterium tuberculosis]] or inorganic particles, such as asbestos bodies or organic particles | **May contain [[bacteria]], such as [[mycobacterium tuberculosis]] or inorganic particles, such as asbestos bodies or organic particles. | ||
**Pneumocystis jirovecii immunofluorescence | **Pneumocystis jirovecii immunofluorescence | ||
==References== | ==References== | ||
Latest revision as of 19:13, 23 March 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]
Overview
There are no diagnostic laboratory findings associated with acute interstitial pneumonitis. However, routine laboratory tests may help in identifying alternative diagnoses rather than making a diagnosis of acute interstitial pneumonitis, include abnormal arterial blood gases, physiologic lung testing, complete blood count, and sputum examination, and microbiologic tests.
Laboratory findings
Laboratory findings consistent with the diagnosis of acute interstitial pneumonitis include:
- Abnormal ABG
- May indicate hypoxia, hypercapnia, and respiratory acidosis.
- Spirometry[1]
- May indicate a restrictive pulmonary disease.
- A FEV1/FVC ratio > 80% indicates restrictive disease.
- Peak flow assessment
- May be below normal range which is 100 liters/minute for men, and 80 liters/minute for women.
- CBC
- May indicate anemia, neutrophilia, elevated ESR, elevated CRP, and elevated immunoglobulin.
- Microbiologic tests:
- Influenza testing using nasopharyngeal aspirates
- Serologic tests for atypical pneumonias (eg, Coccidioides, Chlamydia, coronavirus)
- Urinary antigen tests for Streptococcus pneumoniae and Legionella
- Serologic tests for detection of autoimmune diseases
- Abnormal sputum analysis
- May contain bacteria, such as mycobacterium tuberculosis or inorganic particles, such as asbestos bodies or organic particles.
- Pneumocystis jirovecii immunofluorescence
References
- ↑ Chetta A, Marangio E, Olivieri D (2004). "Pulmonary function testing in interstitial lung diseases". Respiration. 71 (3): 209–13. doi:10.1159/000077416. PMID 15133338.