Gonadoblastoma history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Overview

Patients with gonadoblastoma present either during infancy with ambiguous genitalia or later with sexual developmental complaints. The hallmark of gonadoblastoma is gonadal developmental disorders. The majority of affected individuals are phenotypically women and may be discovered during a workup for virilization and/or primary amenorrhea. Others are phenotypically men with sex organs developmental problems such as cryptorchidism and hypospadias.Although very rarely, gonadoblastoma has been found in anatomically normal male individuals. In this individuals, it may present with a sense of discomfort or pain in testicles.


History and Symptoms

History

Patients with gonadoblastoma may have a positive history of:[1][2]

Common Symptoms

Common symptoms of gonadoblastoma include:

Less Common Symptoms

Less common symptoms of gonadoblastoma include:

References

  1. Saia, Philip (2018). Clinical gynecologic oncology. Philadelphia, PA: Elsevier. ISBN 978-0-323-40067-1.
  2. Chapman WH, Plymyer MR, Dresner ML (December 1990). "Gonadoblastoma in an anatomically normal man: a case report and literature review". J. Urol. 144 (6): 1472–4. PMID 2231948.

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