Gestational trophoblastic neoplasia staging: Difference between revisions

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Latest revision as of 20:12, 11 March 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]Sabawoon Mirwais, M.B.B.S, M.D.[3]

Overview

According to the Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) cancer staging system, there are 4 stages of gestational trophoblastic neoplasia (GTN).

Staging

The Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) staging system ^[1]


Stage	FIGO Anatomical Staging

I	Disease confined to the uterus
II	GTN extends outside of the uterus, but is limited to the genital structures (adnexa, vagina, broad ligament)
III	GTN extends to the lungs, with or without known genital tract involvement
IV	All other metastatic sites

Modified WHO prognostic scoring system as adapted by Fédération Internationale de Gynécologie et d'Obstétrique (FIGO)^[2]

Score	0	1	3	4
Age	< 40	40	-	-
Antecedent pregnancy	Mole	Abortion	Term	-
Interval months from index pregnancy	< 4	4 - < 7	7 - < 13	≥ 13
Pre-treatment serum βhCG (iu/l)	< 10³	10³ - < 10⁴	10⁴ - < 10⁵	≥ 10⁵
Largest tumor size (including uterus)	-	3 - < 5 cm	≥ 5cm	-
Site of metastases	Lung	Spleen, Kidney	Gastrointestinal	Liver, Brain
Number of metastases	-	1 - 4	5 - 8	> 8
Previous failed chemotherapy	-	-	1 drug	2 or more drugs

References

↑ Stage Information for Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq#section/_11 URL Accessed on October 7, 2015
↑ Ngan HY, Bender H, Benedet JL, Jones H, Montruccoli GC, Pecorelli S (October 2003). "Gestational trophoblastic neoplasia, FIGO 2000 staging and classification". Int J Gynaecol Obstet. 83 Suppl 1: 175–7. PMID 14763174.

[eee-1] Stage Information for Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq#section/_11 URL Accessed on October 7, 2015

[pmid14763174-2] Ngan HY, Bender H, Benedet JL, Jones H, Montruccoli GC, Pecorelli S (October 2003). "Gestational trophoblastic neoplasia, FIGO 2000 staging and classification". Int J Gynaecol Obstet. 83 Suppl 1: 175–7. PMID 14763174.

[1]

[2]

@@ Line 1: / Line 1: @@
-{{Choriocarcinoma}}
+{{Gestational trophoblastic neoplasia}}
 __NOTOC__
-{{CMG}}{{AE}}{{MD}}
+{{CMG}}{{AE}}{{MD}}{{Sab}}
 ==Overview==
-According to the Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) [[cancer staging]] system, there are 4 stages of choriocarcinoma.<ref name= eee>Stage Information for Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq#section/_11 URL Accessed on October 7, 2015</ref>
+According to the Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) [[cancer staging]] system, there are 4 stages of gestational trophoblastic neoplasia (GTN).
 ==Staging==
-The Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) staging system is as follows:<ref name= eee>Stage Information for Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq#section/_11 URL Accessed on October 7, 2015</ref>
-{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
+'''The Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) staging system''' <ref name="eee">Stage Information for Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq#section/_11 URL Accessed on October 7, 2015</ref>
-|valign=top|
+{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align="center"
+| valign="top" |
 |+
 ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Stage}}
@@ Line 15: / Line 17: @@
 I
 | style="padding: 5px 5px; background: #F5F5F5;" |
-Disease confined to the uterus
+[[Disease]] confined to the [[uterus]]
 |-
 | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
 II
 | style="padding: 5px 5px; background: #F5F5F5;" |
-GTN extends outside of the uterus, but is limited to the genital structures (adnexa, vagina, broad ligament)
+GTN extends outside of the [[uterus]], but is limited to the genital structures ([[adnexa]], [[vagina]], [[Broad ligament of the uterus|broad ligament]])
 |-
 | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
 III
 | style="padding: 5px 5px; background: #F5F5F5;" |
-GTN extends to the lungs, with or without known genital tract involvement
+GTN extends to the [[Lung|lungs]], with or without known [[Urinary system|genital tract]] involvement
 |-
 | style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
 IV
 | style="padding: 5px 5px; background: #F5F5F5;" |
-All other metastatic sites
+All other [[Metastasis|metastatic]] sites
 |}
-The modified World Health Organization [WHO] prognostic scoring system is as follows:
+'''Modified WHO prognostic scoring system as adapted by Fédération Internationale de Gynécologie et d'Obstétrique (FIGO)'''<ref name="pmid14763174">{{cite journal |vauthors=Ngan HY, Bender H, Benedet JL, Jones H, Montruccoli GC, Pecorelli S |title=Gestational trophoblastic neoplasia, FIGO 2000 staging and classification |journal=Int J Gynaecol Obstet |volume=83 Suppl 1 |issue= |pages=175–7 |date=October 2003 |pmid=14763174 |doi= |url=}}</ref>
-{| {{table}}
-| align="center" style="background:#f0f0f0;"|'''Modified WHO Prognostic Scoring System as Adapted by FIGO'''
+{| {{table}} cellpadding="4" cellspacing="0" style="border:#c9c9c9 1px solid; margin: 1em 1em 1em 0; border-collapse: collapse;"
+! style="background: #4479BA;" | {{fontcolor|#FFF|'''Score'''}}
+! style="background: #4479BA;" | {{fontcolor|#FFF|'''0'''}}
+! style="background: #4479BA;" | {{fontcolor|#FFF|'''1'''}}
+! style="background: #4479BA;" | {{fontcolor|#FFF|'''3'''}}
+! style="background: #4479BA;" | {{fontcolor|#FFF|'''4'''}}
 |-
-| Scores||0||1||2||4
+| style="padding: 5px 5px; background: #DCDCDC; " | Age|| style="padding: 5px 5px; background: #F5F5F5;" |< 40|| style="padding: 5px 5px; background: #F5F5F5;" |40|| style="padding: 5px 5px; background: #F5F5F5;" |-|| style="padding: 5px 5px; background: #F5F5F5;" |-
 |-
-| Age||<40||≥40||–||–
+| style="padding: 5px 5px; background: #DCDCDC; " |Antecedent [[pregnancy]]|| style="padding: 5px 5px; background: #F5F5F5;" |[[Hydatidiform mole|Mole]]|| style="padding: 5px 5px; background: #F5F5F5;" |Abortion|| style="padding: 5px 5px; background: #F5F5F5;" |Term|| style="padding: 5px 5px; background: #F5F5F5;" |-
 |-
-| Antecedent pregnancy||mole||abortion||term||–
+| style="padding: 5px 5px; background: #DCDCDC; " | Interval months from index [[pregnancy]]|| style="padding: 5px 5px; background: #F5F5F5;" |< 4|| style="padding: 5px 5px; background: #F5F5F5;" |4 - < 7|| style="padding: 5px 5px; background: #F5F5F5;" |7 - < 13|| style="padding: 5px 5px; background: #F5F5F5;" |≥ 13
 |-
-| Interval months from index pregnancy||<4||4–6||7–12||>12
+| style="padding: 5px 5px; background: #DCDCDC;" | Pre-treatment [[serum]] [[Human chorionic gonadotropin|βhCG]]
+(iu/l)
+| style="padding: 5px 5px; background: #F5F5F5;" |< 10<sup>3</sup> || style="padding: 5px 5px; background: #F5F5F5;" |10<sup>3</sup> - < 10<sup>4</sup>|| style="padding: 5px 5px; background: #F5F5F5;" |10<sup>4</sup> - < 10<sup>5</sup>|| style="padding: 5px 5px; background: #F5F5F5;" |≥ 10<sup>5</sup>
 |-
-| Pretreatment serum hCG (iu/1)||<103||103–104||104–105||>105
+| style="padding: 5px 5px; background: #DCDCDC;" | Largest [[tumor]] size (including [[uterus]])|| style="padding: 5px 5px; background: #F5F5F5;" |- || style="padding: 5px 5px; background: #F5F5F5;" |3 - < 5 cm|| style="padding: 5px 5px; background: #F5F5F5;" |≥ 5cm|| style="padding: 5px 5px; background: #F5F5F5;" |-
 |-
-| Largest tumor size (including uterus)||<3||3–4 cm||≥5 cm||–
+| style="padding: 5px 5px; background: #DCDCDC; " | Site of [[Metastasis|metastases]]|| style="padding: 5px 5px; background: #F5F5F5;" |[[Lung]]|| style="padding: 5px 5px; background: #F5F5F5;" |[[Spleen]], [[Kidney]]|| style="padding: 5px 5px; background: #F5F5F5;" |[[Gastrointestinal tract|Gastrointestinal]]|| style="padding: 5px 5px; background: #F5F5F5;" |[[Liver]], [[Brain]]
 |-
-| Site of metastases||lung||spleen, kidney||gastrointestinal||liver, brain
+| style="padding: 5px 5px; background: #DCDCDC;" | Number of [[Metastasis|metastases]]|| style="padding: 5px 5px; background: #F5F5F5;" |- || style="padding: 5px 5px; background: #F5F5F5;" |1 - 4|| style="padding: 5px 5px; background: #F5F5F5;" |5 - 8|| style="padding: 5px 5px; background: #F5F5F5;" |> 8
 |-
-| Number of metastases||–||1–4||5–8||>8
+| style="padding: 5px 5px; background: #DCDCDC;" |Previous failed [[chemotherapy]]|| style="padding: 5px 5px; background: #F5F5F5;" |- || style="padding: 5px 5px; background: #F5F5F5;" |-|| style="padding: 5px 5px; background: #F5F5F5;" |1 drug|| style="padding: 5px 5px; background: #F5F5F5;" |2 or more drugs
-|-
-| Previous failed chemotherapy||–||–||single drug||≥2 drugs
 |}
@@ Line 60: / Line 67: @@
 [[Category:Types of cancer]]
 [[Category:Gynecology]]
+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Gynecology]]
+[[Category:Surgery]]

Gestational trophoblastic neoplasia staging: Difference between revisions

Latest revision as of 20:12, 11 March 2019

Overview

Staging

References

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