Gestational trophoblastic neoplasia staging: Difference between revisions
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{{Gestational trophoblastic neoplasia}} | |||
__NOTOC__ | |||
{{CMG}}{{AE}}{{MD}}{{Sab}} | |||
==Overview== | |||
According to the Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) [[cancer staging]] system, there are 4 stages of gestational trophoblastic neoplasia (GTN). | |||
==Staging== | |||
'''The Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) staging system''' <ref name="eee">Stage Information for Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq#section/_11 URL Accessed on October 7, 2015</ref> | |||
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Stage}} | |||
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|FIGO Anatomical Staging}} | |||
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I | |||
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[[Disease]] confined to the [[uterus]] | |||
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II | |||
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GTN extends outside of the [[uterus]], but is limited to the genital structures ([[adnexa]], [[vagina]], [[Broad ligament of the uterus|broad ligament]]) | |||
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III | |||
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GTN extends to the [[Lung|lungs]], with or without known [[Urinary system|genital tract]] involvement | |||
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IV | |||
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All other [[Metastasis|metastatic]] sites | |||
|} | |||
'''Modified WHO prognostic scoring system as adapted by Fédération Internationale de Gynécologie et d'Obstétrique (FIGO)'''<ref name="pmid14763174">{{cite journal |vauthors=Ngan HY, Bender H, Benedet JL, Jones H, Montruccoli GC, Pecorelli S |title=Gestational trophoblastic neoplasia, FIGO 2000 staging and classification |journal=Int J Gynaecol Obstet |volume=83 Suppl 1 |issue= |pages=175–7 |date=October 2003 |pmid=14763174 |doi= |url=}}</ref> | |||
{| {{table}} cellpadding="4" cellspacing="0" style="border:#c9c9c9 1px solid; margin: 1em 1em 1em 0; border-collapse: collapse;" | |||
{{ | ! style="background: #4479BA;" | {{fontcolor|#FFF|'''Score'''}} | ||
! style="background: #4479BA;" | {{fontcolor|#FFF|'''0'''}} | |||
! style="background: #4479BA;" | {{fontcolor|#FFF|'''1'''}} | |||
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|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " | Age|| style="padding: 5px 5px; background: #F5F5F5;" |< 40|| style="padding: 5px 5px; background: #F5F5F5;" |40|| style="padding: 5px 5px; background: #F5F5F5;" |-|| style="padding: 5px 5px; background: #F5F5F5;" |- | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " |Antecedent [[pregnancy]]|| style="padding: 5px 5px; background: #F5F5F5;" |[[Hydatidiform mole|Mole]]|| style="padding: 5px 5px; background: #F5F5F5;" |Abortion|| style="padding: 5px 5px; background: #F5F5F5;" |Term|| style="padding: 5px 5px; background: #F5F5F5;" |- | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " | Interval months from index [[pregnancy]]|| style="padding: 5px 5px; background: #F5F5F5;" |< 4|| style="padding: 5px 5px; background: #F5F5F5;" |4 - < 7|| style="padding: 5px 5px; background: #F5F5F5;" |7 - < 13|| style="padding: 5px 5px; background: #F5F5F5;" |≥ 13 | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC;" | Pre-treatment [[serum]] [[Human chorionic gonadotropin|βhCG]] | |||
(iu/l) | |||
| style="padding: 5px 5px; background: #F5F5F5;" |< 10<sup>3</sup> || style="padding: 5px 5px; background: #F5F5F5;" |10<sup>3</sup> - < 10<sup>4</sup>|| style="padding: 5px 5px; background: #F5F5F5;" |10<sup>4</sup> - < 10<sup>5</sup>|| style="padding: 5px 5px; background: #F5F5F5;" |≥ 10<sup>5</sup> | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC;" | Largest [[tumor]] size (including [[uterus]])|| style="padding: 5px 5px; background: #F5F5F5;" |- || style="padding: 5px 5px; background: #F5F5F5;" |3 - < 5 cm|| style="padding: 5px 5px; background: #F5F5F5;" |≥ 5cm|| style="padding: 5px 5px; background: #F5F5F5;" |- | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC; " | Site of [[Metastasis|metastases]]|| style="padding: 5px 5px; background: #F5F5F5;" |[[Lung]]|| style="padding: 5px 5px; background: #F5F5F5;" |[[Spleen]], [[Kidney]]|| style="padding: 5px 5px; background: #F5F5F5;" |[[Gastrointestinal tract|Gastrointestinal]]|| style="padding: 5px 5px; background: #F5F5F5;" |[[Liver]], [[Brain]] | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC;" | Number of [[Metastasis|metastases]]|| style="padding: 5px 5px; background: #F5F5F5;" |- || style="padding: 5px 5px; background: #F5F5F5;" |1 - 4|| style="padding: 5px 5px; background: #F5F5F5;" |5 - 8|| style="padding: 5px 5px; background: #F5F5F5;" |> 8 | |||
|- | |||
| style="padding: 5px 5px; background: #DCDCDC;" |Previous failed [[chemotherapy]]|| style="padding: 5px 5px; background: #F5F5F5;" |- || style="padding: 5px 5px; background: #F5F5F5;" |-|| style="padding: 5px 5px; background: #F5F5F5;" |1 drug|| style="padding: 5px 5px; background: #F5F5F5;" |2 or more drugs | |||
|} | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Types of cancer]] | |||
[[Category:Gynecology]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Gynecology]] | |||
[[Category:Surgery]] |
Latest revision as of 20:12, 11 March 2019
Gestational trophoblastic neoplasia Microchapters |
Differentiating Gestational trophoblastic neoplasia from other Diseases |
---|
Diagnosis |
Treatment |
Case Studies |
Gestational trophoblastic neoplasia staging On the Web |
American Roentgen Ray Society Images of Gestational trophoblastic neoplasia staging |
Directions to Hospitals Treating Gestational trophoblastic neoplasia |
Risk calculators and risk factors for Gestational trophoblastic neoplasia staging |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]Sabawoon Mirwais, M.B.B.S, M.D.[3]
Overview
According to the Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) cancer staging system, there are 4 stages of gestational trophoblastic neoplasia (GTN).
Staging
The Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) staging system [1]
Stage | FIGO Anatomical Staging |
---|---|
I |
|
II |
GTN extends outside of the uterus, but is limited to the genital structures (adnexa, vagina, broad ligament) |
III |
GTN extends to the lungs, with or without known genital tract involvement |
IV |
All other metastatic sites |
Modified WHO prognostic scoring system as adapted by Fédération Internationale de Gynécologie et d'Obstétrique (FIGO)[2]
Score | 0 | 1 | 3 | 4 |
---|---|---|---|---|
Age | < 40 | 40 | - | - |
Antecedent pregnancy | Mole | Abortion | Term | - |
Interval months from index pregnancy | < 4 | 4 - < 7 | 7 - < 13 | ≥ 13 |
Pre-treatment serum βhCG
(iu/l) |
< 103 | 103 - < 104 | 104 - < 105 | ≥ 105 |
Largest tumor size (including uterus) | - | 3 - < 5 cm | ≥ 5cm | - |
Site of metastases | Lung | Spleen, Kidney | Gastrointestinal | Liver, Brain |
Number of metastases | - | 1 - 4 | 5 - 8 | > 8 |
Previous failed chemotherapy | - | - | 1 drug | 2 or more drugs |
References
- ↑ Stage Information for Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq#section/_11 URL Accessed on October 7, 2015
- ↑ Ngan HY, Bender H, Benedet JL, Jones H, Montruccoli GC, Pecorelli S (October 2003). "Gestational trophoblastic neoplasia, FIGO 2000 staging and classification". Int J Gynaecol Obstet. 83 Suppl 1: 175–7. PMID 14763174.