Focal segmental glomerulosclerosis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]; Associate Editor-In-Chief:’’’Olufunmilola Olubukola M.D.[3] Cafer Zorkun, M.D., Ph.D. [4]

Overview

Causes

According to D'Agati and colleagues,^[1] FSGS may be primary of secondary. Primary FSGS is defined as idiopathic FSGS, whereas secondary FSGS is defined as FSGS other etiologies.^[1] The following list shows all the causes of FSGS^[2]:

Primary (Idiopathic) FSGS

Secondary FSGS

Familial

Mutations in alpha actinin 4
Mutations in NPHS1 (nephrin)
Mutations in NPHS2 (podocin)
Mutations in WT-1
Mutations in TRPC6
Mutations in SCARB2 (LIMP2)
Mutations in INF2 (formin)
Mutations in CD2-associated protein
Mitochondrial cytopathies

Virus Associated

Medication

Adaptive Structural-Functional Responses

Reduced Kidney Size

Oligomeganephronia
Unilateral kidney agenesis
Kidney dysplasia
Cortical necrosis
Reflux nephropathy
Surgical kidney ablation
Chronic allograft nephropathy
Any advanced kidney disease with reduction in functioning nephrons

Initially Normal Kidney Mass

Malignancy

Lymphoma

Nonspecific Pattern of FSGS Caused by Kidney Scarring in Glomerular Disease

Focal proliferative glomerulonephritis
- IgA nephropathy
- Lupus nephritis
- Pauci-immune focal necrotizing and crescentic glomerulonephritis
Alport's syndrome (hereditary nephritis)
Membranous nephropathy
Thrombotic microangiopathy

References

↑ ^1.0 ^1.1 D'Agati V (2003). "Pathologic classification of focal segmental glomerulosclerosis". Semin Nephrol. 23 (2): 117–34. doi:10.1053/snep.2003.50012. PMID 12704572.
↑ Beck L, Bomback AS, Choi MJ, Holzman LB, Langford C, Mariani LH; et al. (2013). "KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis". Am J Kidney Dis. 62 (3): 403–41. doi:10.1053/j.ajkd.2013.06.002. PMID 23871408.

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[pmid12704572-1] 1.0 ^1.1 D'Agati V (2003). "Pathologic classification of focal segmental glomerulosclerosis". Semin Nephrol. 23 (2): 117–34. doi:10.1053/snep.2003.50012. PMID 12704572.

[pmid23871408-2] Beck L, Bomback AS, Choi MJ, Holzman LB, Langford C, Mariani LH; et al. (2013). "KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis". Am J Kidney Dis. 62 (3): 403–41. doi:10.1053/j.ajkd.2013.06.002. PMID 23871408.

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