Esthesioneuroblastoma differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Esthesioneuroblastoma must be differentiated from olfactory neuroepithelioma, olfactory groove meningioma/haemangiopericytoma, sinonasal carcinoma, rhabdomyosarcoma, melanoma metastases, lymphoma, chordoma, juvenile nasopharyngeal angiofibroma, and pituitary macroadenoma. Esthesioneuroblastoma must be differentiated from other tumors with similar histological appearance, such as lymphoma, Ewing sarcoma, melanoma, olfactory/ other [rhabdomyosarcoma or Merkel cell carcinoma], neuroblastoma, and small cell carcinoma.
Differential Diagnosis
Distinguishing esthesioneuroblastomas from the other tumors is of paramount importance because the tumors respond differently to various treatment modalities. The following list describes the outcome of each of these diseases with various immunohistochemical tests. The differential diagnosis of esthesioneuroblastoma includes the following:
- Olfactory neuroepithelioma
- Olfactory groove meningioma/haemangiopericytoma
- Sinonasal carcinoma (including SCC, minor salivary gland adenocarcinoma)
- Rhabdomyosarcoma
- Melanoma metastases
- Lymphoma
- Chordoma
- Juvenile nasopharyngeal angiofibroma
- Pituitary macroadenoma
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