Esthesioneuroblastoma other diagnostic studies
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Esthesioneuroblastoma Microchapters | |
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Diagnosis | |
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Esthesioneuroblastoma other diagnostic studies On the Web | |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Biopsy may be helpful in the diagnosis of esthesioneuroblastoma. Findings on biopsy diagnostic of esthesioneuroblastoma include small, round-to-oval cells with coarsely granular chromatin, prominent nuclear membranes, multiple small nucleoli, and scant cytoplasm with pseudorosettes or occasional Homer-Wright rosettes separated by fibrous septa. Calcification and necrosis are sometimes seen while mitotic figures are rare.[1]
Other Diagnostic Studies
- The diagnosis of esthesioneuroblastoma requires a tissue biopsy, which is usually obtained during detailed examination of the nasal cavity.
- Biopsy and endoscopy should be performed under general anesthesia. The specimen should be sent for regular staining, as well as for immunohistochemistry and possibly electron microscopy.
- Many patients who undergo sinus surgery, may have the diagnosis of esthesioneuroblastoma established as an unexpected pathologic finding. Therefore, sending all the tissue removed during sinus surgery for pathologic examination is crucial for diagnosis of esthesioneuroblastoma.
- Early referral for an intranasal biopsy is essential to early diagnosis of esthesioneuroblastoma.[1]
For immunohistochemistry, click here. For histopathology, click here.
References
- ↑ 1.0 1.1 Kane AJ, Sughrue ME, Rutkowski MJ, Aranda D, Mills SA, Buencamino R; et al. (2010). "Posttreatment prognosis of patients with esthesioneuroblastoma". J Neurosurg. 113 (2): 340–51. doi:10.3171/2010.2.JNS091897. PMID 20345216.