Diabetes mellitus type 2 surgery: Difference between revisions
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{{CMG}};{{AE}}{{MehdiP}} | {{CMG}};{{AE}}{{MehdiP}} | ||
==Overview== | ==Overview== | ||
[[Pancreas]] and [[Islets of Langerhans|islet cell]] [[Organ transplant|transplantation]] is considered in patients with chronic [[diabetes]] who have frequent [[metabolic]] [[complication(medicine)|complications]] and are intolerant to exogenous [[insulin]] or have failed [[insulin]] [[therapy]]. | [[Pancreas]] and [[Islets of Langerhans|islet cell]] [[Organ transplant|transplantation]] is considered in patients with chronic [[diabetes]] who have frequent [[metabolic]] [[complication (medicine)|complications]] and are intolerant to exogenous [[insulin]] or have failed [[insulin]] [[therapy]]. | ||
==Surgery== | ==Surgery== | ||
*There is no indication for [[surgery]] in [[type 2 diabetes mellitus]] unless, there is an [[indication]] for [[pancreas]] and [[Islets of Langerhans|islet cell]] [[Organ transplant|transplantation]]. [[Pancreas]] and [[Islets of Langerhans|islet cell]] [[Organ transplant|transplantation]] have been shown to normalize [[glucose]] levels but require lifelong [[immunosuppression]] to prevent [[Transplant rejection|graft rejection]] and recurrence of autoimmune islet destruction. [[Islets of Langerhans|Islet cell]] [[Organ transplant|transplantation]] remains investigational. [[Pancreas transplantation]] is considered for patients with chronic [[diabetes]] and multiple [[complication(medicine)|complications]]. | *There is no indication for [[surgery]] in [[type 2 diabetes mellitus]] unless, there is an [[indication]] for [[pancreas]] and [[Islets of Langerhans|islet cell]] [[Organ transplant|transplantation]]. [[Pancreas]] and [[Islets of Langerhans|islet cell]] [[Organ transplant|transplantation]] have been shown to normalize [[glucose]] levels but require lifelong [[immunosuppression]] to prevent [[Transplant rejection|graft rejection]] and recurrence of autoimmune islet destruction. [[Islets of Langerhans|Islet cell]] [[Organ transplant|transplantation]] remains investigational. [[Pancreas transplantation]] is considered for patients with chronic [[diabetes]] and multiple [[complication (medicine)|complications]]. | ||
*Indication for pancreas transplantation is:<ref name="pmid16567844">{{cite journal |vauthors=Robertson RP, Davis C, Larsen J, Stratta R, Sutherland DE |title=Pancreas and islet transplantation in type 1 diabetes |journal=Diabetes Care |volume=29 |issue=4 |pages=935 |year=2006 |pmid=16567844 |doi= |url=}}</ref> | *Indication for pancreas transplantation is:<ref name="pmid16567844">{{cite journal |vauthors=Robertson RP, Davis C, Larsen J, Stratta R, Sutherland DE |title=Pancreas and islet transplantation in type 1 diabetes |journal=Diabetes Care |volume=29 |issue=4 |pages=935 |year=2006 |pmid=16567844 |doi= |url=}}</ref> | ||
**Patients who have history of frequent severe metabolic derangement ([[hypoglycemia]], marked [[hyperglycemia]], [[ketoacidosis]]), intolerant to exogenous [[insulin]] [[therapy]] or failure of treatment with [[insulin]]. | **Patients who have history of frequent severe metabolic derangement ([[hypoglycemia]], marked [[hyperglycemia]], [[ketoacidosis]]), intolerant to exogenous [[insulin]] [[therapy]] or failure of treatment with [[insulin]]. | ||
Revision as of 20:12, 11 August 2020
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Diabetes mellitus type 2 Microchapters |
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Differentiating Diabetes Mellitus Type 2 from other Diseases |
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Diagnosis |
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Treatment |
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Medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Seyedmahdi Pahlavani, M.D. [2]
Overview
Pancreas and islet cell transplantation is considered in patients with chronic diabetes who have frequent metabolic complications and are intolerant to exogenous insulin or have failed insulin therapy.
Surgery
- There is no indication for surgery in type 2 diabetes mellitus unless, there is an indication for pancreas and islet cell transplantation. Pancreas and islet cell transplantation have been shown to normalize glucose levels but require lifelong immunosuppression to prevent graft rejection and recurrence of autoimmune islet destruction. Islet cell transplantation remains investigational. Pancreas transplantation is considered for patients with chronic diabetes and multiple complications.
- Indication for pancreas transplantation is:[1]
- Patients who have history of frequent severe metabolic derangement (hypoglycemia, marked hyperglycemia, ketoacidosis), intolerant to exogenous insulin therapy or failure of treatment with insulin.