Desmoid tumor diagnostic study of choice: Difference between revisions

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{{CMG}} {{AE}}{{S.M.}}
{{CMG}} {{AE}}{{S.M.}}
==Overview==
==Overview==
Definitive diagnosis of a desmoid tumor can only be established by histological examination of a biopsy specimen. Electron microscopy can be done which shows spindle cells of desmoids appearing as myofibroblasts. Immunohistochemical stains show high nuclear reactivity for beta-catenin accumulation in nucleus.
Definitive diagnosis of a desmoid tumor can only be established by histological examination of a biopsy specimen. Electron microscopy can be done which shows spindle cells of desmoids appearing as myofibroblasts.


==Diagnostic study of choice==
==Diagnostic study of choice==
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*Electron microscopy is performed to obtain further clarity and confirmation for the diagnosis
*Electron microscopy is performed to obtain further clarity and confirmation for the diagnosis
*Spindle cells of desmoid tumors appear to be myofibroblasts on electron microscopy which represents an abnormal proliferation of myofibroblasts, which normally disappear gradually during the later stages of wound healing
*Spindle cells of desmoid tumors appear to be myofibroblasts on electron microscopy which represents an abnormal proliferation of myofibroblasts, which normally disappear gradually during the later stages of wound healing
*Immunohistochemical stains are done to look for nuclear accumulation of beta-catenin
*Regardless of the site, 90% of desmoids show nuclear reactivity (has relatively high specificity)

Revision as of 19:47, 1 March 2019

Desmoid tumor Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Desmoid tumor from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

CT

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Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

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Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]

Overview

Definitive diagnosis of a desmoid tumor can only be established by histological examination of a biopsy specimen. Electron microscopy can be done which shows spindle cells of desmoids appearing as myofibroblasts.

Diagnostic study of choice

  • Biopsy is the most important and conclusive diagnostic procedure for desmoid tumor
  • After biopsy, definitive diagnosis must be established on histopathologic analysis
  • Electron microscopy is performed to obtain further clarity and confirmation for the diagnosis
  • Spindle cells of desmoid tumors appear to be myofibroblasts on electron microscopy which represents an abnormal proliferation of myofibroblasts, which normally disappear gradually during the later stages of wound healing