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Revision as of 22:17, 20 January 2013

Amyloidosis Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Primary amyloidosis
Secondary amyloidosis
Familial amyloidosis
Wild-type (senile) amyloidosis
Cardiac amyloidosis
Beta-2 microglobulin related amyloidosis
Gelsolin related amyloidosis
Lysozyme amyloid related amyloidosis
Leucocyte cell-derived chemotaxin 2 related amyloidosis
Fibrinogen A alpha-chain associated amyloidosis

Pathophysiology

Causes

Differentiating Amyloidosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

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Laboratory Findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Laboratory findings in amyloidosis include an elevated erythrocyte sedimentation rate and an increased BUN level. Serum creatinine, protein, casts, or fat bodies can also be found in the urine. Serum troponin, B-type natriuretic peptide, and beta-2-microglobulin are prognostic markers for heart failure. Amyloid deposits can be identified histologically by Congo red staining and viewing under polarized light. Amyloid deposits are easily recognized because they produce a distinctive 'apple green birefringence'. Alternatively, a thioflavin T stain may be used. Also, an abdominal fat pad aspiration, rectal mucosa biopsy, or bone marrow biopsy can help confirm the diagnosis. These tests reveal positive findings in 80% of patients.

Laboratory Findings

References

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