Adult T-cell leukemia classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Based on both the clinical presentation and laboratory findings, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smoldering variant, or an adult T-cell lymphoma variant.

Classification

  • Based on both the clinical presentation and laboratory findings, adult T-cell leukemia may be classified into either an acute variant, chronic variant, smouldering variant, or an adult T-cell lymphoma variant.[1][2]
  • The table below lists the adult T-cell leukemia clinical classification details:
Clinical Variant Description
Acute adult T-cell leukemia[3]
[[Chronic adult T-cell leukemia [4]]]
[[Primary cutaneous tumoral (PCT)[5]]]
  • Cutaneous involvement. Nodules on the skin.
  • Poor prognosis.
  • Normal serum LDH level (or less that twice the normal upper limit)
  • Normal serum calcium level
Smoldering adult T-cell leukemia [1]
Adult T-cell lymphoma

References

  1. 1.0 1.1 Matutes E (2007). "Adult T-cell leukaemia/lymphoma". J Clin Pathol. 60 (12): 1373–7. doi:10.1136/jcp.2007.052456. PMC 2095573. PMID 18042693.
  2. Shimoyama M (1991). "Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87)". Br J Haematol. 79 (3): 428–37. PMID 1751370.
  3. Tsukasaki K, Hermine O, Bazarbachi A, Ratner L, Ramos JC, Harrington W, O'Mahony D, Janik JE, Bittencourt AL, Taylor GP, Yamaguchi K, Utsunomiya A, Tobinai K, Watanabe T (January 2009). "Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting". J. Clin. Oncol. 27 (3): 453–9. doi:10.1200/JCO.2008.18.2428. PMC 2737379. PMID 19064971.
  4. Setoyama M, Katahira Y, Kanzaki T (December 1999). "Clinicopathologic analysis of 124 cases of adult T-cell leukemia/lymphoma with cutaneous manifestations: the smouldering type with skin manifestations has a poorer prognosis than previously thought". J. Dermatol. 26 (12): 785–90. PMID 10659498.
  5. Sawada Y, Shimauchi T, Yamaguchi T, Okura R, Hama-Yamamoto K, Fueki-Yoshioka H, Ohmori S, Yamada S, Yoshizawa M, Hiromasa K, Tajiri M, Kabashima-Kubo R, Yoshioka M, Sugita K, Yoshiki R, Hino R, Kobayashi M, Izu K, Nakamura M, Tokura Y (March 2013). "Combination of skin-directed therapy and oral etoposide for smoldering adult T-cell leukemia/lymphoma with skin involvement". Leuk. Lymphoma. 54 (3): 520–7. doi:10.3109/10428194.2012.715351. PMID 22830614.