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==Overview==
==Overview==
Common cold was first considered by Benjamin Franklin in the 18th century.
Common cold was first considered a distinct diagnosis by Benjamin Franklin in the 18th century.


==Historical Perspective==
==Historical Perspective==


* In the 18th century, Benjamin Franklin considered the causes and prevention of the common cold.  
* In the 18th century, Benjamin Franklin considered the causes and prevention of the common cold.  
* After several years of research he concluded: "People often catch a cold from one another when shut up together in small close rooms, coaches and when sitting near and conversing so as to breathe in each other's transpiration."  
* After several years of research, he concluded that "People often catch a cold from one another when shut up together in small close rooms, or coaches; and when sitting near and conversing, so as to breathe in each other's transpiration."  
* Although viruses had not yet been discovered, Franklin hypothesized that the common cold was passed between people through the air.  
* Although [[Virus|viruses]] had not yet been discovered, Franklin hypothesized that the common cold was passed between people through the air.  
* He recommended exercise, bathing, and moderation in food and drink consumption to avoid the common cold.<ref>{{cite web | url = http://www.loc.gov/exhibits/treasures/franklin-scientist.html | title = Scientist and Inventor: Benjamin Franklin: In His Own Words... (AmericanTreasures of the Library of Congress)}}</ref> Franklin's theory on the transmission of the cold was confirmed some 150 years later.<ref name="pmid14795755">{{cite journal | author = Andrewes CH, Lovelock JE, Sommerville T  | title = An experiment on the transmission of colds | journal = Lancet | volume = 1 | issue = 1 | pages = 25–7 | year = 1951 | pmid = 14795755 | doi = }}</ref>
* He recommended exercise, bathing, and moderation in food and drink consumption to avoid the common cold.<ref>{{cite web | url = http://www.loc.gov/exhibits/treasures/franklin-scientist.html | title = Scientist and Inventor: Benjamin Franklin: In His Own Words... (AmericanTreasures of the Library of Congress)}}</ref> Franklin's theory on the [[Transmission (medicine)|transmission]] of the cold was confirmed about 150 years later.<ref name="pmid14795755">{{cite journal | author = Andrewes CH, Lovelock JE, Sommerville T  | title = An experiment on the transmission of colds | journal = Lancet | volume = 1 | issue = 1 | pages = 25–7 | year = 1951 | pmid = 14795755 | doi = }}</ref>


===Common Cold Unit===
===Common Cold Unit (CCU)===


{| style="float: right; width: 200px;"
* In the United Kingdom, the [[Common Cold Unit]] (CCU) was set up by the civilian [[Medical Research Council (UK)|Medical Research Council]] in 1946.  The unit worked with volunteers who were infected with various viruses.<ref>{{cite book | title = Das Buch der verrückten Experimente (Broschiert) | author = Reto U. Schneider | year = 2004 | isbn = 344215393X | url = http://www.verrueckte-experimente.de/index_e.html}}</ref>
| [[Image:Definition of a Cold by Benjamin Franklin Page 1.jpg|right|200px|thumb|Definition of a Cold." Benjamin Franklin's notes for a paper he intended to write on the common cold.]]]
 
|}
* The [[rhinovirus]] was discovered in the [[Common Cold Unit|CCU]] in the 1950s; scientists were able to culture the virus on a [[tissue culture]].
* In the 1970s, the [[Common Cold Unit|CCU]] proved that using [[interferon]] during the [[incubation period]] could be potentially protective against developing the infection.
* In 1987, the unit completed its research on [[zinc gluconate]] lozenges for [[prophylaxis]] against [[rhinovirus]].<ref name="pmid3440773">{{cite journal| author=Al-Nakib W, Higgins PG, Barrow I, Batstone G, Tyrrell DA| title=Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges. | journal=J Antimicrob Chemother | year= 1987 | volume= 20 | issue= 6 | pages= 893-901 | pmid=3440773 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3440773  }} </ref>
* In 1989, the unit was closed.<ref name="pmid1329647">{{cite journal |vauthors=Tyrrell DA |title=A view from the Common Cold Unit |journal=Antiviral Res. |volume=18 |issue=2 |pages=105–25 |year=1992 |pmid=1329647 |doi= |url=}}</ref>


* In the United Kingdom, the [[Common Cold Unit]] was set up by the civilian [[Medical Research Council (UK)|Medical Research Council]] in 1946.  The unit worked with volunteers who were infected with various viruses.<ref>{{cite book | title = Das Buch der verrückten Experimente (Broschiert) | author = Reto U. Schneider | year = 2004 | isbn = 344215393X | url = http://www.verrueckte-experimente.de/index_e.html}}</ref>
* The rhinovirus was discovered there. In the late 1950s, researchers were able to grow one of these cold viruses in a [[tissue culture]], as it would not grow in fertilized chicken eggs, the method used for many other viruses.
* In the 1970s, the CCU demonstrated that treatment with [[interferon]] during the incubation phase of rhinovirus infection protects somewhat against the disease, but no practical treatment could be developed.
* The unit was closed in 1989, two years after it completed research of zinc gluconate lozenges in the prophylaxis and treatment of rhinovirus colds.<ref>{{cite journal
| journal = J Antimicrob Chemother.
| year = 1987
| month = December
| volume = 20
| issue = 6
| pages = 893-901
| title = Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges
| last = Al-Nakib
| first = W
| coauthors = Higgins PG, Barrow I, Batstone G, Tyrrell DA.
| pmid = 3440773
}}</ref>
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==References==
==References==
{{reflist|2}}
{{reflist|2}}
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Latest revision as of 20:17, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Ahmed Younes M.B.B.CH [2]

Overview

Common cold was first considered a distinct diagnosis by Benjamin Franklin in the 18th century.

Historical Perspective

  • In the 18th century, Benjamin Franklin considered the causes and prevention of the common cold.
  • After several years of research, he concluded that "People often catch a cold from one another when shut up together in small close rooms, or coaches; and when sitting near and conversing, so as to breathe in each other's transpiration."
  • Although viruses had not yet been discovered, Franklin hypothesized that the common cold was passed between people through the air.
  • He recommended exercise, bathing, and moderation in food and drink consumption to avoid the common cold.[1] Franklin's theory on the transmission of the cold was confirmed about 150 years later.[2]

Common Cold Unit (CCU)









References

  1. "Scientist and Inventor: Benjamin Franklin: In His Own Words... (AmericanTreasures of the Library of Congress)".
  2. Andrewes CH, Lovelock JE, Sommerville T (1951). "An experiment on the transmission of colds". Lancet. 1 (1): 25–7. PMID 14795755.
  3. Reto U. Schneider (2004). Das Buch der verrückten Experimente (Broschiert). ISBN 344215393X.
  4. Al-Nakib W, Higgins PG, Barrow I, Batstone G, Tyrrell DA (1987). "Prophylaxis and treatment of rhinovirus colds with zinc gluconate lozenges". J Antimicrob Chemother. 20 (6): 893–901. PMID 3440773.
  5. Tyrrell DA (1992). "A view from the Common Cold Unit". Antiviral Res. 18 (2): 105–25. PMID 1329647.