Acute liver failure risk factors: Difference between revisions
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==Risk Factors== | ==Risk Factors== | ||
*Drug-related | Risk factors in the development of acute liver failure include: | ||
*Drug-related [[hepatotoxicity]] and [[idiosyncratic]] drug reactions are the most common risk factor in the developed world. The most common drug causing hepatotoxicity is [[acetaminophen]]. | |||
*[[Viral hepatitis]] is the most common risk factor of acute liver failure in the developing world. | |||
:*[[Hepatitis A virus]], [[Hepatitis B virus]], [[Hepatitis D virus]], or [[Hepatitis E virus]]. | :*[[Hepatitis A virus]], [[Hepatitis B virus]], [[Hepatitis D virus]], or [[Hepatitis E virus]]. | ||
:*Other atypical viruses | :*Other [[atypical viruses]] causing [[viral hepatitis]] and [[fulminant hepatic failure]], include [[cytomegalovirus]], [[hemorrhagic fever virus]]es, [[herpes simplex virus]], [[paramyxovirus]] and [[Epstein-Barr virus]]. | ||
*Old age | *Old age | ||
*Malnourishment | *[[Malnourishment]] | ||
*Vascular diseases | *[[Vascular diseases]] | ||
:*[[Ischemic hepatitis]] | :*[[Ischemic hepatitis]] | ||
:*Hepatic vein thrombosis ([[Budd-Chiari syndrome]]) | :*[[Hepatic vein thrombosis]] ([[Budd-Chiari syndrome]]) | ||
:*Hepatic veno-occlusive disease | :*[[Hepatic veno-occlusive]] disease | ||
:*[[Portal vein thrombosis]] | :*[[Portal vein thrombosis]] | ||
*Autoimmune disease | *[[Autoimmune disease]] | ||
:*[[Autoimmune hepatitis]] | :*[[Autoimmune hepatitis]] | ||
*Metabolic diseases | *[[Metabolic diseases]] | ||
:*Acute fatty liver of pregnancy | :*[[Acute fatty liver of pregnancy]] | ||
:*[[Alpha-1 antitrypsin deficiency]] | :*[[Alpha-1 antitrypsin deficiency]] | ||
:*[[Reye syndrome]] | :*[[Reye syndrome]] | ||
:*[[Tyrosinemia]] | :*[[Tyrosinemia]] | ||
:*[[HELLP syndrome]] | :*[[HELLP syndrome]] | ||
*Malignancy | *[[Malignancy]] | ||
:*Primary liver tumor: [[Hepatocellular carcinoma]] | :*[[Primary liver tumor]]: [[Hepatocellular carcinoma]] | ||
:*Secondary liver tumor: Extensive hepatic metastases or infiltration from [[breast cancer]], [[lung cancer]], [[melanoma]], [[lymphoma]], [[leukemia]]. | :*[[Secondary liver tumor]]: Extensive hepatic metastases or infiltration from [[breast cancer]], [[lung cancer]], [[melanoma]], [[lymphoma]], [[leukemia]]. | ||
*Long term | *Long-term lcohol consumption | ||
*Immunocompromised state | *[[Immunocompromised state]] | ||
*Other systemic diseases | *[[Other systemic diseases]] | ||
**Sepsis | **[[Sepsis]] | ||
**Cardiac failure | **[[Cardiac failure]] | ||
**Respiratory failure | **[[Respiratory failure]] | ||
**Renal failure | **[[Renal failure]] | ||
==References== | ==References== | ||
Revision as of 14:40, 31 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:
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Overview
Certain conditions can put a person at risk for developing acute liver failure. These include having certain infections, vascular disorders, autoimmune conditions, metabolic diseases, and primary cancers or malignancies.
Risk Factors
Risk factors in the development of acute liver failure include:
- Drug-related hepatotoxicity and idiosyncratic drug reactions are the most common risk factor in the developed world. The most common drug causing hepatotoxicity is acetaminophen.
- Viral hepatitis is the most common risk factor of acute liver failure in the developing world.
- Old age
- Malnourishment
- Vascular diseases
- Primary liver tumor: Hepatocellular carcinoma
- Secondary liver tumor: Extensive hepatic metastases or infiltration from breast cancer, lung cancer, melanoma, lymphoma, leukemia.
- Long-term lcohol consumption
- Immunocompromised state
- Other systemic diseases