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This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.[2]
↑Tsao YK, Wei CF, Robberson DL, Gotto AM, Chan L (Dec 1985). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". The Journal of Biological Chemistry. 260 (28): 15222–31. PMID2415515.
↑Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". Journal of Lipid Research. 39 (1): 152–61. PMID9469594.
Blanco-Vaca F, Escolà-Gil JC, Martín-Campos JM, Julve J (Nov 2001). "Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein". Journal of Lipid Research. 42 (11): 1727–39. PMID11714842.
Kalopissis AD, Pastier D, Chambaz J (Apr 2003). "Apolipoprotein A-II: beyond genetic associations with lipid disorders and insulin resistance". Current Opinion in Lipidology. 14 (2): 165–72. doi:10.1097/00041433-200304000-00008. PMID12642785.
Vollmer E, Brust J, Roessner A, Bosse A, Burwikel F, Kaesberg B, Harrach B, Robenek H, Böcker W (1991). "Distribution patterns of apolipoproteins A1, A2, and B in the wall of atherosclerotic vessels". Virchows Archiv A. 419 (2): 79–88. doi:10.1007/BF01600220. PMID1908160.
Gordon JI, Sims HF, Edelstein C, Scanu AM, Strauss AW (Nov 1985). "Extracellular processing of proapolipoprotein A-II in Hep G2 cell cultures is mediated by a 54-kDa protease immunologically related to cathepsin B". The Journal of Biological Chemistry. 260 (27): 14824–31. PMID2414299.
Middleton-Price HR, van den Berghe JA, Scott J, Knott TJ, Malcolm S (Jul 1988). "Regional chromosomal localisation of APOA2 to 1q21-1q23". Human Genetics. 79 (3): 283–5. doi:10.1007/BF00366253. PMID3136074.
Shelley CS, Sharpe CR, Baralle FE, Shoulders CC (Nov 1985). "Comparison of the human apolipoprotein genes. Apo AII presents a unique functional intron-exon junction". Journal of Molecular Biology. 186 (1): 43–51. doi:10.1016/0022-2836(85)90255-4. PMID3935800.
Lux SE, John KM, Ronan R, Brewer HB (Dec 1972). "Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein". The Journal of Biological Chemistry. 247 (23): 7519–27. PMID4344225.
Moore MN, Kao FT, Tsao YK, Chan L (Aug 1984). "Human apolipoprotein A-II: nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1". Biochemical and Biophysical Research Communications. 123 (1): 1–7. doi:10.1016/0006-291X(84)90371-1. PMID6089788.
Gordon JI, Budelier KA, Sims HF, Edelstein C, Scanu AM, Strauss AW (Nov 1983). "Biosynthesis of human preproapolipoprotein A-II". The Journal of Biological Chemistry. 258 (22): 14054–9. PMID6315718.
Stoffel W, Krüger E, Deutzmann R (Mar 1983). "Cell-free translation of human liver apolipoprotein AI and AII mRNA. Processing of primary translation products". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 364 (3): 227–37. doi:10.1515/bchm2.1983.364.1.227. PMID6407957.
Knott TJ, Priestley LM, Urdea M, Scott J (May 1984). "Isolation and characterisation of a cDNA encoding the precursor for human apolipoprotein AII". Biochemical and Biophysical Research Communications. 120 (3): 734–40. doi:10.1016/S0006-291X(84)80168-0. PMID6428397.
Lackner KJ, Law SW, Brewer HB, Sakaguchi AY, Naylor SL (Aug 1984). "The human apolipoprotein A-II gene is located on chromosome 1". Biochemical and Biophysical Research Communications. 122 (3): 877–83. doi:10.1016/0006-291X(84)91172-0. PMID6433912.