AKR1B10: Difference between revisions

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{{Infobox_gene}}
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'''Aldo-keto reductase family 1 member B10''' is an [[enzyme]] that in humans is encoded by the ''AKR1B10'' [[gene]].<ref name="pmid9765596">{{cite journal | vauthors = Hyndman DJ, Flynn TG | title = Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family | journal = Biochim Biophys Acta | volume = 1399 | issue = 2–3 | pages = 198–202 |date=Oct 1998 | pmid = 9765596 | pmc =  | doi = 10.1016/s0167-4781(98)00109-2}}</ref><ref name="pmid9565553">{{cite journal | vauthors = Cao D, Fan ST, Chung SS | title = Identification and characterization of a novel human aldose reductase-like gene | journal = J Biol Chem | volume = 273 | issue = 19 | pages = 11429–35 |date=Jun 1998 | pmid = 9565553 | pmc =  | doi =10.1074/jbc.273.19.11429 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57016| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_AKR1B10_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1zua.
| PDB = {{PDB2|1zua}}
| Name = Aldo-keto reductase family 1, member B10 (aldose reductase)
| HGNCid = 382
| Symbol = AKR1B10
| AltSymbols =; ARL1; HIS; AKR1B11; AKR1B12; ALDRLn; ARL-1; HSI; MGC14103
| OMIM = 604707
| ECnumber =
| Homologene = 68934
| MGIid = 107673
  | Function = {{GNF_GO|id=GO:0004033 |text = aldo-keto reductase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0006081 |text = aldehyde metabolic process}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 57016
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_064695
    | Hs_RefseqmRNA = NM_020299
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot =   
    | Mm_EntrezGene = 14187
    | Mm_Ensembl = ENSMUSG00000029762
    | Mm_RefseqmRNA = NM_008012
    | Mm_RefseqProtein = NP_032038
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 34284322
    | Mm_GenLoc_end = 34298612
    | Mm_Uniprot = P45377
  }}
}}
'''Aldo-keto reductase family 1, member B10 (aldose reductase)''', also known as '''AKR1B10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57016| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57016| accessdate = }}</ref>
| summary_text = This gene encodes a member of the [[aldo-keto reductase|aldo/keto reductase superfamily]], which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57016| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|AKR1B10}}
* {{UCSC gene info|ARL1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Scuric Z, Stain SC, Anderson WF, Hwang JJ |title=New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma. |journal=Hepatology |volume=27 |issue= 4 |pages= 943-50 |year= 1998 |pmid= 9537432 |doi= 10.1002/hep.510270408 }}
*{{cite journal  | vauthors=Scuric Z, Stain SC, Anderson WF, Hwang JJ |title=New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma |journal=Hepatology |volume=27 |issue= 4 |pages= 943–50 |year= 1998 |pmid= 9537432 |doi= 10.1002/hep.510270408 }}
*{{cite journal  | author=Cao D, Fan ST, Chung SS |title=Identification and characterization of a novel human aldose reductase-like gene. |journal=J. Biol. Chem. |volume=273 |issue= 19 |pages= 11429-35 |year= 1998 |pmid= 9565553 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Hyndman DJ, Flynn TG |title=Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family. |journal=Biochim. Biophys. Acta |volume=1399 |issue= 2-3 |pages= 198-202 |year= 1998 |pmid= 9765596 |doi=  }}
*{{cite journal  | vauthors=Crosas B, Hyndman DJ, Gallego O |title=Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism |journal=Biochem. J. |volume=373 |issue= Pt 3 |pages= 973–9 |year= 2003 |pmid= 12732097 |doi= 10.1042/BJ20021818 | pmc=1223539 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Crosas B, Hyndman DJ, Gallego O, ''et al.'' |title=Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism. |journal=Biochem. J. |volume=373 |issue= Pt 3 |pages= 973-9 |year= 2003 |pmid= 12732097 |doi= 10.1042/BJ20021818 }}
*{{cite journal  | vauthors=Petrovic MG, Peterlin B, Hawlina M, Petrovic D |title=Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in Type 2 diabetes in Caucasians |journal=J. Diabetes Complicat. |volume=19 |issue= 2 |pages= 70–3 |year= 2005 |pmid= 15745835 |doi= 10.1016/j.jdiacomp.2004.08.004 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Kang ES, Kim HJ, Paek KS |title=Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation |journal=Cell. Mol. Life Sci. |volume=62 |issue= 10 |pages= 1146–55 |year= 2005 |pmid= 15928807 |doi= 10.1007/s00018-005-5024-4 |display-authors=etal}}
*{{cite journal  | author=Petrovic MG, Peterlin B, Hawlina M, Petrovic D |title=Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in Type 2 diabetes in Caucasians. |journal=J. Diabetes Complicat. |volume=19 |issue= 2 |pages= 70-3 |year= 2005 |pmid= 15745835 |doi= 10.1016/j.jdiacomp.2004.08.004 }}
*{{cite journal  | vauthors=Lee YS, Paek KS, Kang ES |title=Involvement of nuclear factor kappaB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells |journal=Int. J. Biochem. Cell Biol. |volume=37 |issue= 11 |pages= 2297–309 |year= 2005 |pmid= 15936242 |doi= 10.1016/j.biocel.2005.04.016 |display-authors=etal}}
*{{cite journal  | author=Kang ES, Kim HJ, Paek KS, ''et al.'' |title=Phorbol ester up-regulates aldose reductase expression in A549 cells: a potential role for aldose reductase in cell cycle modulation. |journal=Cell. Mol. Life Sci. |volume=62 |issue= 10 |pages= 1146-55 |year= 2005 |pmid= 15928807 |doi= 10.1007/s00018-005-5024-4 }}
*{{cite journal  | vauthors=Vikramadithyan RK, Hu Y, Noh HL |title=Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice |journal=J. Clin. Invest. |volume=115 |issue= 9 |pages= 2434–43 |year= 2005 |pmid= 16127462 |doi= 10.1172/JCI24819 | pmc=1190371 |display-authors=etal}}
*{{cite journal  | author=Lee YS, Paek KS, Kang ES, ''et al.'' |title=Involvement of nuclear factor kappaB in up-regulation of aldose reductase gene expression by 12-O-tetradecanoylphorbol-13-acetate in HeLa cells. |journal=Int. J. Biochem. Cell Biol. |volume=37 |issue= 11 |pages= 2297-309 |year= 2005 |pmid= 15936242 |doi= 10.1016/j.biocel.2005.04.016 }}
*{{cite journal  | vauthors=Hazemann I, Dauvergne MT, Blakeley MP |title=High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase |journal=Acta Crystallogr. D |volume=61 |issue= Pt 10 |pages= 1413–7 |year= 2005 |pmid= 16204895 |doi= 10.1107/S0907444905024285 |display-authors=etal}}
*{{cite journal  | author=Vikramadithyan RK, Hu Y, Noh HL, ''et al.'' |title=Human aldose reductase expression accelerates diabetic atherosclerosis in transgenic mice. |journal=J. Clin. Invest. |volume=115 |issue= 9 |pages= 2434-43 |year= 2005 |pmid= 16127462 |doi= 10.1172/JCI24819 }}
*{{cite journal  | vauthors=Mashkova TD, ((Oparina NIu)), Zinov'eva OL |title=[Transcription TIMP3, DAPk1 and AKR1B10 genes in squamous cell lung cancer] |journal=Mol. Biol. (Mosk.) |volume=40 |issue= 6 |pages= 1047–54 |year= 2007 |pmid= 17209433 |doi=  10.1134/s0026893306060148|display-authors=etal}}
*{{cite journal  | author=Hazemann I, Dauvergne MT, Blakeley MP, ''et al.'' |title=High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=61 |issue= Pt 10 |pages= 1413-7 |year= 2005 |pmid= 16204895 |doi= 10.1107/S0907444905024285 }}
*{{cite journal  | vauthors=Tammali R, Ramana KV, Srivastava SK |title=Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells |journal=Cancer Lett. |volume=252 |issue= 2 |pages= 299–306 |year= 2007 |pmid= 17300864 |doi= 10.1016/j.canlet.2007.01.001 | pmc=1945127 }}
*{{cite journal  | author=Mashkova TD, Oparina NIu, Zinov'eva OL, ''et al.'' |title=[Transcription TIMP3, DAPk1 and AKR1B10 genes in squamous cell lung cancer] |journal=Mol. Biol. (Mosk.) |volume=40 |issue= 6 |pages= 1047-54 |year= 2007 |pmid= 17209433 |doi=  }}
*{{cite journal  | vauthors=Yan R, Zu X, Ma J |title=Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention |journal=Int. J. Cancer |volume=121 |issue= 10 |pages= 2301–6 |year= 2007 |pmid= 17597105 |doi= 10.1002/ijc.22933 |display-authors=etal}}
*{{cite journal  | author=Tammali R, Ramana KV, Srivastava SK |title=Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. |journal=Cancer Lett. |volume=252 |issue= 2 |pages= 299-306 |year= 2007 |pmid= 17300864 |doi= 10.1016/j.canlet.2007.01.001 }}
*{{cite journal  | author=Yan R, Zu X, Ma J, ''et al.'' |title=Aldo-keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention. |journal=Int. J. Cancer |volume=121 |issue= 10 |pages= 2301-6 |year= 2007 |pmid= 17597105 |doi= 10.1002/ijc.22933 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=57016}}
{{Alcohol oxidoreductases}}
{{Enzymes}}
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[[Category:EC 1.1.1]]


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Latest revision as of 17:55, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene.[1][2][3]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.[3]

References

  1. ↑ Hyndman DJ, Flynn TG (Oct 1998). "Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family". Biochim Biophys Acta. 1399 (2–3): 198–202. doi:10.1016/s0167-4781(98)00109-2. PMID 9765596.
  2. ↑ Cao D, Fan ST, Chung SS (Jun 1998). "Identification and characterization of a novel human aldose reductase-like gene". J Biol Chem. 273 (19): 11429–35. doi:10.1074/jbc.273.19.11429. PMID 9565553.
  3. ↑ 3.0 3.1 "Entrez Gene: AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)".

External links

Further reading


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