Malate dehydrogenase (NADP+)

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In enzymology, a malate dehydrogenase (NADP+) (EC is an enzyme that catalyzes the chemical reaction

(S)-malate + NADP+ oxaloacetate + NADPH + H+

Thus, the two substrates of this enzyme are (S)-malate and NADP+, whereas its 3 products are oxaloacetate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NADP+ oxidoreductase. Other names in common use include NADP+-malic enzyme, NADP+-malate dehydrogenase, malic dehydrogenase (nicotinamide adenine dinucleotide phosphate), malate NADP+ dehydrogenase, NADP+ malate dehydrogenase, NADP+-linked malate dehydrogenase, and malate dehydrogenase (NADP+). This enzyme participates in pyruvate metabolism and carbon fixation. This enzyme has at least one effector, hn.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1CIV and 7MDH.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
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  • Connelly JL, Danner DJ, Bowden JA (1968). "Branched chain alpha-keto acid metabolism. I. Isolation, purification, and partial characterization of bovine liver alpha-ketoisocaproic:alpha-keto-beta-methylvaleric acid dehydrogenase". J. Biol. Chem. 243: 1198&ndash, 203. PMID 5689906.
  • Johnson HS (1971). "NADP-malate dehydrogenase: photoactivation in leaves of plants with Calvin cycle photosynthesis". Biochem. Biophys. Res. Commun. 43: 703&ndash, 9. PMID 4397919.
  • Johnson HS, Hatch MD (1970). "Properties and regulation of leaf nicotinamide-adenine dinucleotide phosphate-malate dehydrogenase and 'malic' enzyme in plants with the C4-dicarboxylic acid pathway of photosynthesis". Biochem. J. 119: 273&ndash, 80. PMID 4395182.

External links

The CAS registry number for this enzyme class is 37250-19-4.

Gene Ontology (GO) codes