Malate dehydrogenase (decarboxylating)

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In enzymology, a malate dehydrogenase (decarboxylating) (EC is an enzyme that catalyzes the chemical reaction

(S)-malate + NAD+ pyruvate + CO2 + NADH

Thus, the two substrates of this enzyme are (S)-malate and NAD+, whereas its 3 products are pyruvate, CO2, and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NAD+ oxidoreductase (decarboxylating). Other names in common use include 'malic' enzyme, pyruvic-malic carboxylase, NAD+-specific malic enzyme, and NAD+-malic enzyme. This enzyme participates in pyruvate metabolism and carbon fixation.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1DO8, 1EFK, 1EFL, 1PJ2, 1PJ3, 1PJ4, and 1QR6.


  • IUBMB entry for
  • BRENDA references for (Recommended.)
  • PubMed references for
  • PubMed Central references for
  • Google Scholar references for
  • Saz HJ and Hubbard JA (1957). "The oxidative decarboxylation of malate by Ascoris lumbricoides". J. Biol. Chem. 225: 921&ndash, 933.

External links

The CAS registry number for this enzyme class is 9028-46-0.

Gene Ontology (GO) codes