Non-bacterial thrombotic endocarditis laboratory findings

non-bacterial thrombotic endocarditis
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Differentiating non-bacterial thrombotic endocarditis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
X-ray
Echocardiography and Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Interventions
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Non-bacterial thrombotic endocarditis laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Non-bacterial thrombotic endocarditis laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Non-bacterial thrombotic endocarditis laboratory findings
CDC on Non-bacterial thrombotic endocarditis laboratory findings
Non-bacterial thrombotic endocarditis laboratory findings in the news
Blogs on Non-bacterial thrombotic endocarditis laboratory findings
Directions to Hospitals Treating Psoriasis
Risk calculators and risk factors for Non-bacterial thrombotic endocarditis laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aisha Adigun, B.Sc., M.D.[2]

Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal for patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

• There are no specific diagnostic laboratory findings associated with non-bacterial thrombotic endocarditis.
• The following laboratory tests are usually conducted to detect the underlying cause of NBTE and differentiate it from infective endocarditis;

Hematological and coagulation studies

• CBC: may show neutrophilia and anemia
• Prothrombin time, partial thromboplastin time, fibrinogen, thrombin time, D-dimers, and cross-linked fibrin degradation products (abnormal values may depict DIC).

Blood cultures

• Multiple blood cultures (minimum to 3 blood cultures prior to antibiotic use) to rule out infective endocarditis and other infectious etiologies.

Immunological assays

• Antinuclear antibodies (SLE screening)
• Anti-dsDNA antibodies (SLE confirmation and to monitor the progress of disease and lupus nephritis)
• Anti-Smith antibodies
• Anti-RNP
• Antiphospholipid antibodies
• Anticardiolipin antibodies (associated with an increased risk of cardiac abnormalities)
• Anti-Ro/SSA
• Anti-La/SSB
• False-positive serology in the form of VDRL is also common in SLE

Inflammatory markers

The following inflammatory markers are often elevated

• C-reactive protein
• Erythrocyte sedimentation rate (ESR)

Polymerase chain reaction (PCR)

• PCR is a rapid and reliable method to detect the culture-negative endocarditis by fastidious organisms.