Multiple endocrine neoplasia type 2 history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
History
Symptoms
Multiple endocrine neoplasia type 2b
The most common clinical features of MEN2B are:
- a tall, thin, "marfanoid" body build, in which long bones are disproportionately elongated;
- masses beneath mucosal surfaces in the mouth, lips, and eyes (discussed below);
- low muscle mass, sometimes with myopathy;
- gastrointestinal complaints, especially constipation;
- symptoms derived from medullary carcinoma of the thyroid;
- symptoms derived from pheochromocytoma;
- craniosynostosis;
- dry eyes or lack of tears, which is an especially helpful sign in children;
- delayed puberty.