Barrett's esophagus pathophysiology: Difference between revisions

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[[image:Esophagus with intestinal metaplasia -- intermed mag.jpg|thumb|center|Histology of Barrett's esophagus ([By Nephron (Own work) [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0) or GFDL (http://www.gnu.org/copyleft/fdl.html)], via Wikimedia Commons])]]
[[image:Esophagus with intestinal metaplasia -- intermed mag.jpg|thumb|center|Histology of Barrett's esophagus ([By Nephron (Own work) [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0) or GFDL (http://www.gnu.org/copyleft/fdl.html)], via Wikimedia Commons])]]
==Genetics==
*There is no significant genetic predisposition associated with Barrett's esophagus.


==Associated Conditions==
==Associated Conditions==

Revision as of 14:27, 31 January 2018

Barrett's Esophagus Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Barrett's Esophagus from other Diseases

Epidemiology and Demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amresh Kumar MD [2]

Overview

Barrett's esophagus is marked by the presence of columnar epithelium in the lower esophagus, replacing the normal squamous cell epithelium; an example of metaplasia. The columnar epithelium is better able to withstand the erosive action of the gastric secretions; however, this metaplasia confers an increased cancer risk of the adenocarcinoma type.[1]

Pathophysiology

Pathogenesis

Microscopic Pathology

  • On microscopic histopathological analysis, gastric junctional type epithelium, gastric fundus type epithelium and specialized intestinal columnar metaplasia are characteristic findings of Barrett's esophagus.


Histology of Barrett's esophagus ([By Nephron (Own work) [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0) or GFDL (http://www.gnu.org/copyleft/fdl.html)], via Wikimedia Commons])

Associated Conditions

Gross Pathology

By Nephron Source: Libre Pathology

References

  1. Fléjou J (2005). "Barrett's oesophagus: from metaplasia to dysplasia and cancer". Gut. 54 Suppl 1: i6–12. PMID 15711008.

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