Barrett's esophagus pathophysiology: Difference between revisions

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*:* [[Patients]] with BE tend to have more severe [[GERD]].
*:* [[Patients]] with BE tend to have more severe [[GERD]].
* Although one would think that BE develops over years, with [[slow]] replacement of [[squamous]] [[cells]] by [[columnar]] [[cells]], it appears that this is not the case. BE tends to develop all at once with little or no progression. The reason for this is unknown.
* Although one would think that BE develops over years, with [[slow]] replacement of [[squamous]] [[cells]] by [[columnar]] [[cells]], it appears that this is not the case. BE tends to develop all at once with little or no progression. The reason for this is unknown.
* Paull et.al. described three types of [[columnar epithelium]] that can be seen in BE:
*:* [[Gastric]] junctional-type [[epithelium]] which has a pitted (foveolar) surface and mucus-secreting cells.
*:* [[Gastric]] fundus-type [[epithelium]] that also has a pitted surface lined by mucus-secreting cells, in addition to having a deeper [[glandular]] layer that contains [[chief]] and [[parietal cells]].
*:* Specialized [[intestinal]] (columnar) [[metaplasia]] that has a villiform surface with [[mucus]] secreting [[columnar]] [[cells]] and [[goblet cells]].


==Microscopic Pathology==
==Microscopic Pathology==

Revision as of 21:27, 24 January 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amresh Kumar MD [2]

Overview

Barrett's esophagus is marked by the presence of columnar epithelium in the lower esophagus, replacing the normal squamous cell epithelium; an example of metaplasia. The columnar epithelium is better able to withstand the erosive action of the gastric secretions; however, this metaplasia confers an increased cancer risk of the adenocarcinoma type.[1]

Pathophysiology

Microscopic Pathology

  • On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

References

  1. Fléjou J (2005). "Barrett's oesophagus: from metaplasia to dysplasia and cancer". Gut. 54 Suppl 1: i6–12. PMID 15711008.

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