Barrett's esophagus pathophysiology: Difference between revisions

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* [[Barrett's esophagus]] is marked by the presence of [[columnar epithelium]] in the lower [[esophagus]], replacing the [[normal]] [[squamous cell]] [[epithelium]]; an example of [[metaplasia]]. The [[columnar epithelium]] is better able to withstand the erosive action of the [[gastric]] [[secretions]]; however, this [[metaplasia]] confers an increased [[cancer]] risk of the [[adenocarcinoma]] type.<ref name="Fléjou_2005">{{cite journal |author=Fléjou J |title=Barrett's oesophagus: from metaplasia to dysplasia and cancer |journal=Gut |volume=54 Suppl 1 |issue= |pages=i6-12 |year=2005 |pmid=15711008}}</ref>
* [[Barrett's esophagus]] is marked by the presence of [[columnar epithelium]] in the lower [[esophagus]], replacing the [[normal]] [[squamous cell]] [[epithelium]]; an example of [[metaplasia]]. The [[columnar epithelium]] is better able to withstand the erosive action of the [[gastric]] [[secretions]]; however, this [[metaplasia]] confers an increased [[cancer]] risk of the [[adenocarcinoma]] type.<ref name="Fléjou_2005">{{cite journal |author=Fléjou J |title=Barrett's oesophagus: from metaplasia to dysplasia and cancer |journal=Gut |volume=54 Suppl 1 |issue= |pages=i6-12 |year=2005 |pmid=15711008}}</ref>


* The metaplastic [[columnar]] [[cells]] may be of two types: [[gastric]] (similar to those in the [[stomach]], which is NOT technically [[Barrett's esophagus]]) or colonic (similar to [[cells]] in the [[intestine]]). A [[biopsy]] of the affected [[area]] will often contain a mixture of the two. Colonic-type [[metaplasia]] is the type of [[metaplasia]] associated with increased risk of [[malignancy]] in [[genetically]] susceptible people.
* The metaplastic [[columnar]] [[cells]] may be of two types: [[gastric]] (similar to those in the [[stomach]], which is NOT technically [[Barrett's esophagus]]) or colonic similar to [[cells]] in the [[intestine]]. A [[biopsy]] of the affected [[area]] will often contain a mixture of the two. Colonic-type [[metaplasia]] is the type of [[metaplasia]] associated with increased risk of [[malignancy]] in [[genetically]] susceptible people.


* The [[metaplasia]] of [[Barrett's esophagus]] is visible grossly through a [[gastroscope]], but [[biopsy]] specimens must be [[examined]] under a [[microscope]] to determine whether [[cells]] are [[gastric]] or colonic in [[nature]]. Colonic [[metaplasia]] is usually identified by finding [[goblet cells]] in the [[epithelium]] and is necessary for the final [[diagnosis]] of Barrett's.
* The [[metaplasia]] of [[Barrett's esophagus]] is visible grossly through a [[gastroscope]], but [[biopsy]] specimens must be [[examined]] under a [[microscope]] to determine whether [[cells]] are [[gastric]] or colonic in [[nature]]. Colonic [[metaplasia]] is usually identified by finding [[goblet cells]] in the [[epithelium]] and is necessary for the final [[diagnosis]] of Barrett's.

Revision as of 21:12, 24 January 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amresh Kumar MD [2]

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  • On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

References

  1. Fléjou J (2005). "Barrett's oesophagus: from metaplasia to dysplasia and cancer". Gut. 54 Suppl 1: i6–12. PMID 15711008.

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