Sandbox: malabsorption: Difference between revisions

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* Low  [[Vitamin A|vitamins A]], [[Vitamin D|D]], E, and K  
* Low  [[Vitamin A|vitamins A]], [[Vitamin D|D]], E, and K  
* [[Anemia]]  
* [[Anemia]]  
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* Disease hetergenicity lead to varying presentation from chronic [[diarrhea]] without significant fat [[Malabsorption|malabsorptio]]<nowiki/>n to severe [[watery diarrhea]] and steatorrhea with [[malnutrition]]
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* [[Genetic defects]] in ''SLC10A2'' (solute carrier family 10 member 2 gene)
* [[Genetic defects]] in ''SLC10A2'' (solute carrier family 10 member 2 gene)
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* Total and specific [[bile acid]]<nowiki/>s from stool
* Total and specific [[bile acids]] from stool
* [[Gamma emitter selenium-75-homocholic acid taurine]] (SeHCAT)
* Gamma emitter selenium-75-homocholic acid taurine ([[SeHCAT]])
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! align="center" style="background:#DCDCDC;" |[[Abetalipoproteinemia]]
! align="center" style="background:#DCDCDC;" |[[Abetalipoproteinemia]]
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| style="padding: 5px 5px; background: #F5F5F5;" align="center" |Infancy
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Adult
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* [[Abdominal distension|Abdominal distention]]
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* Impaired [[visual acuity]] and [[Visual field defect|visual field defects]]
* [[Abdominal distension]]
* [[Visual field defect]]
* [[Dysarthria]]
* [[Dysarthria]]
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* Low [[triglyceride]]
* Low [[triglyceride]]
* Low total [[cholesterol]] levels 
* Low total [[cholesterol]] levels 
* [[Acanthocytes]]
* [[Acanthocytes]]
* Low [[vitamin E]] levels
* Low [[vitamin E]] levels
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* [[Clumsiness]]
* Visual impairment
* Vision impairment
* [[Ataxia]]
* [[Ataxia]]
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* [[Autosomal recessive]] disorder caused by mutations encoding the [[microsomal]] [[triglyceride]] transfer protein (MTP)
* [[Autosomal recessive]] disorder caused by mutations encoding the [[microsomal]] [[triglyceride]] transfer protein (MTP)
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* Clinical findings and low [[triglyceride]] and [[cholesterol]] level
* Clinical findings and low [[triglyceride]] and [[cholesterol]] level
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! align="center" style="background:#DCDCDC;" |[[Microscopic colitis]]
! align="center" style="background:#DCDCDC;" |[[Microscopic colitis]]

Revision as of 21:50, 9 November 2017

Abbreviations: WBC: White blood cells; Plt: Platelets, Hgb: Hemoglobin, IgE: Immunoglobulin E, IgA: Immunoglobulin A

Cause Peak age of onset History Physical exam Lab findings Additional findings Cause/Pathogenesis Gold standard diagnosis
Fever Abdominal pain Diarrhea Weight loss
Watery Fatty WBC Hgb Plt Other lab findings
Whipple's disease 40-60 +/- + + + + ↓/↑
Celiac disease Childhood

Adult

- + +/- +/- + - -
  • IgA endomysial antibody
  • Anti-tissue transglutaminase antibody
  • Anti-gliadin antibody
  • IgA endomysial antibody
  • IgA tissue transglutaminase antibody
Cystic fibrosis Childhood

Adult

+ + - + +
  • Positive DNA analysis for CFTR multimutation method
  • Evaluated nasal transepithelial potential difference (NPD)
Crohns disease Young adults

(20th)

+ + + + +
  • Abnormal immune response to self antigens
Irritable bowel syndrome 30-50 - +/- +/- +/- - - - -
  • Diagnosis of exclusion
VIPoma 30-50 - + + + +
  • Primary secretory tumor
  • Elevated VIP levels
  • Followed by imaging
Zollinger-Ellison syndrome) 20-50
  • Elevated basal or stimulated serum gastrin> 1000 pg/mL
Lactose intolerance Any age +
Eosinophilic gastroenteritis  30th - + + + + - -
Primary bile acid malabsorption Childhood Adult
  • Total and specific bile acids from stool
  • Gamma emitter selenium-75-homocholic acid taurine (SeHCAT)
Abetalipoproteinemia Infancy

Adult

- - -
Microscopic colitis 60th + - + +
Hyperthyroidism Any age + - + +/-
  • Elevated T4
  • Elevated T3
  • Decreased level of TSH
Grain allergy Childhood - + + - +