Multiple endocrine neoplasia type 2 risk factors: Difference between revisions
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{{CMG}}; {{AE}} {{Ammu}} | {{CMG}}; {{AE}} {{Ammu}} | ||
==Overview== | ==Overview== | ||
Common risk factor in the development of multiple endocrine neoplasia type 2 is family history. | Common risk factor in the development of multiple endocrine neoplasia type 2 is [[family history]]. | ||
==Risk Factors== | ==Risk Factors== | ||
* | * [[Family history]] is the common risk factor in the development of multiple endocrine neoplasia type 2..<ref>[https://en.wikipedia.org/wiki/Multiple_endocrine_neoplasia_type_2] Wikipedia Multiple endocrine neoplasia type 2; MEN2</ref> | ||
* During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999 [6], the risk of MTC has been stratified in three categories according to the mutations of c-RET as following. | * During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999 [6], the risk of MTC has been stratified in three categories according to the mutations of c-RET as following. | ||
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! style="background: #F5F5F5;" | Children with MEN2B and/or c-RET codon 883, 918, | ! style="background: #F5F5F5;" | Children with MEN2B and/or c-RET codon 883, 918, | ||
922 | 922 | ||
! style="background: #F5F5F5;" | Highest risk of aggressive | ! style="background: #F5F5F5;" | Highest risk of aggressive [[medullary thyroid cancer]] | ||
|- | |- | ||
! style="background: #F5F5F5;" | Children with any c-RET codon 611, 618, 620 or 634 | ! style="background: #F5F5F5;" | Children with any c-RET codon 611, 618, 620 or 634 | ||
mutations | mutations | ||
! style="background: #F5F5F5;" | High risk of | ! style="background: #F5F5F5;" | High risk of [[medullary thyroid cancer]] | ||
|- | |- | ||
! style="background: #F5F5F5;" | Children with c-RET codon 609, 768, 790, 791, 804 | ! style="background: #F5F5F5;" | Children with c-RET codon 609, 768, 790, 791, 804 | ||
and 891 mutations | and 891 mutations | ||
! style="background: #F5F5F5;" | Less aggressive and slowly growing | ! style="background: #F5F5F5;" | Less aggressive and slowly growing [[medullary thyroid cancer]] | ||
|} | |} | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 15:15, 28 September 2015
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Multiple endocrine neoplasia type 2 Microchapters |
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Differentiating Multiple endocrine neoplasia type 2 from other Diseases |
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Multiple endocrine neoplasia type 2 risk factors On the Web |
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Multiple endocrine neoplasia type 2 risk factors in the news |
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Directions to Hospitals Treating Multiple endocrine neoplasia type 2 |
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Risk calculators and risk factors for Multiple endocrine neoplasia type 2 risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [3]
Overview
Common risk factor in the development of multiple endocrine neoplasia type 2 is family history.
Risk Factors
- Family history is the common risk factor in the development of multiple endocrine neoplasia type 2..[1]
- During the Seventh International Multiple Endocrine Neoplasia Meeting in Gubbio in 1999 [6], the risk of MTC has been stratified in three categories according to the mutations of c-RET as following.
| Gene | Risk |
|---|---|
| Children with MEN2B and/or c-RET codon 883, 918,
922 |
Highest risk of aggressive medullary thyroid cancer |
| Children with any c-RET codon 611, 618, 620 or 634
mutations |
High risk of medullary thyroid cancer |
| Children with c-RET codon 609, 768, 790, 791, 804
and 891 mutations |
Less aggressive and slowly growing medullary thyroid cancer |