Non-bacterial thrombotic endocarditis laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
*There are no specific diagnostic laboratory findings associated with non-bacterial thrombotic endocarditis. | *There are no specific [[diagnostic]] laboratory findings associated with [[non-bacterial thrombotic endocarditis]]. | ||
*The following laboratory tests are usually conducted to detect the underlying cause of NBTE and differentiate it from infective endocarditis; | *The following laboratory tests are usually conducted to detect the underlying cause of NBTE and differentiate it from [[infective endocarditis]]; | ||
===Hematological and coagulation studies === | ===Hematological and coagulation studies === | ||
*CBC: may show neutrophilia and anemia | *[[Complete blood count|CBC]]: may show [[neutrophilia]] and [[anemia]] | ||
*Prothrombin time, partial thromboplastin time, fibrinogen, thrombin time, D-dimers, and cross-linked fibrin degradation products (abnormal values may depict DIC). | *[[Prothrombin time]], [[partial thromboplastin time]], [[fibrinogen]], [[thrombin time]], [[D-dimer|D-dimers]], and cross-linked [[Fibrin degradation product|fibrin degradation products]] (abnormal values may depict [[Disseminated intravascular coagulation|DIC]]). | ||
===Blood cultures=== | ===Blood cultures=== | ||
*Multiple blood cultures (minimum to 3 blood cultures prior to antibiotic use) to rule out infective endocarditis and other infectious etiologies. | *Multiple [[Blood culture|blood cultures]] (minimum to 3 blood cultures prior to antibiotic use) to rule out [[infective endocarditis]] and other infectious etiologies. | ||
===Immunological assays=== | ===Immunological assays=== | ||
*[[Antinuclear antibodies]] ([[SLE]] [[Screening test|screening]]) | *[[Antinuclear antibodies]] ([[SLE]] [[Screening test|screening]]) | ||
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===Inflammatory markers=== | ===Inflammatory markers=== | ||
The following inflammatory markers are often elevated | The following inflammatory markers are often elevated | ||
*C-reactive protein | *[[C-reactive protein]] | ||
*Erythrocyte sedimentation rate (ESR) | *[[Erythrocyte sedimentation rate]] (ESR) | ||
===Polymerase chain reaction (PCR)=== | ===Polymerase chain reaction (PCR)=== | ||
*PCR is a rapid and reliable method to detect the culture-negative endocarditis by fastidious organisms. | *[[PCR]] is a rapid and reliable method to detect the culture-negative endocarditis by fastidious organisms. | ||
==References== | ==References== | ||
Revision as of 17:58, 16 August 2020
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non-bacterial thrombotic endocarditis |
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Differentiating non-bacterial thrombotic endocarditis from other Diseases |
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Diagnosis |
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Treatment |
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Non-bacterial thrombotic endocarditis laboratory findings On the Web |
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Risk calculators and risk factors for Non-bacterial thrombotic endocarditis laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aisha Adigun, B.Sc., M.D.[2]
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].
OR
Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
OR
[Test] is usually normal for patients with [disease name].
OR
Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].
OR
There are no diagnostic laboratory findings associated with [disease name].
Laboratory Findings
- There are no specific diagnostic laboratory findings associated with non-bacterial thrombotic endocarditis.
- The following laboratory tests are usually conducted to detect the underlying cause of NBTE and differentiate it from infective endocarditis;
Hematological and coagulation studies
- CBC: may show neutrophilia and anemia
- Prothrombin time, partial thromboplastin time, fibrinogen, thrombin time, D-dimers, and cross-linked fibrin degradation products (abnormal values may depict DIC).
Blood cultures
- Multiple blood cultures (minimum to 3 blood cultures prior to antibiotic use) to rule out infective endocarditis and other infectious etiologies.
Immunological assays
- Antinuclear antibodies (SLE screening)
- Anti-dsDNA antibodies (SLE confirmation and to monitor the progress of disease and lupus nephritis)
- Anti-Smith antibodies
- Anti-RNP
- Antiphospholipid antibodies
- Anticardiolipin antibodies (associated with an increased risk of cardiac abnormalities)
- Anti-Ro/SSA
- Anti-La/SSB
- False-positive serology in the form of VDRL is also common in SLE
Inflammatory markers
The following inflammatory markers are often elevated
Polymerase chain reaction (PCR)
- PCR is a rapid and reliable method to detect the culture-negative endocarditis by fastidious organisms.