Esthesioneuroblastoma differential diagnosis: Difference between revisions
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*Esthesioneuroblastomas stain positive for neuron-specific enolase and/or S-100 protein, | *Esthesioneuroblastomas stain positive for neuron-specific enolase and/or S-100 protein, | ||
* | *The stain is negative for desmin, cytokeratin, vimentin, actin, glial fibrillary acidic protein, UMB 45, and the common leukocytic antigen. | ||
*For difficult cases, electron microscopy can be useful. | *For difficult cases, electron microscopy can be useful. | ||
*Common features are small, round neuroepithelial cells arranged in rosette or pseudorosette patterns, separated by fibrous elements. | *Common features are small, round neuroepithelial cells arranged in rosette or pseudorosette patterns, separated by fibrous elements. The rosettes consist of a central space ringed by columnar cells with radially oriented nuclei. | ||
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:Ewing sarcoma | :Ewing sarcoma | ||
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*Ewing sarcoma is positive for MIC2/CD99 gene products that result from an 11;22 translocation | *Ewing sarcoma is positive for MIC2/CD99 gene products that result from an 11;22 translocation. | ||
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:Merkel cell carcinoma | :Merkel cell carcinoma | ||
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* | *Merkel cell carcinoma stains positively for low-molecular-weight cytokeratin 20 and NSE. | ||
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Revision as of 15:23, 22 February 2016
Esthesioneuroblastoma Microchapters | |
Diagnosis | |
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Treatment | |
Case Studies | |
Esthesioneuroblastoma differential diagnosis On the Web | |
American Roentgen Ray Society Images of Esthesioneuroblastoma differential diagnosis | |
Risk calculators and risk factors for Esthesioneuroblastoma differential diagnosis | |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Esthesioneuroblastoma must be differentiated from other tumors with similar histological appearance, such as lymphoma, Ewing sarcoma, melanoma, rhabdomyosarcoma or Merkel cell carcinoma, and small cell carcinoma. Distinguishing esthesioneuroblastomas from the other tumors is of paramount importance because the tumors respond differently to various treatment modalities.[1][2]
Differential Diagnosis
The differential diagnosis of esthesioneuroblastoma includes the following:[1][2]
- Olfactory neuroepithelioma
- Olfactory groove meningioma/haemangiopericytoma
- Sinonasal carcinoma (including SCC, minor salivary gland adenocarcinoma)
- Rhabdomyosarcoma
- Nasopharyngeal carcinoma
- Melanoma metastases
- Lymphoma
- Chordoma
- Juvenile nasopharyngeal angiofibroma
- Pituitary macroadenoma
The outcome of following diseases with various immunohistochemical tests is shown below in a tabular form:
Disease | Immunohistochemical Tests |
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References
- ↑ 1.0 1.1 Esthesioneuroblastoma. Radiopedia(2015) http://radiopaedia.org/articles/olfactory-neuroblastoma Accessed on January 25, 2016
- ↑ 2.0 2.1 Argani P, Perez-Ordoñez B, Xiao H, Caruana SM, Huvos AG, Ladanyi M (1998). "Olfactory neuroblastoma is not related to the Ewing family of tumors: absence of EWS/FLI1 gene fusion and MIC2 expression". Am J Surg Pathol. 22 (4): 391–8. PMID 9580174.