Amyloidosis history and symptoms: Difference between revisions

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== Overview==
== Overview==
In amyloidosis, the range of [[symptoms]] depends on specific [[Tissue (biology)|tissues]] and [[organs]] involved. [[Symptoms]] can be quite diverse.
Common [[symptoms]] of amyloidosis include [[abdominal pain]], [[edema]] and [[enlarged tongue]]. Less common [[symptoms]] of amyloidosis include [[Gastrointestinal bleeding|gastrointestinal bleeding, gross]] [[hematuria]], [[hoarseness]] and [[paresthesias]].  


==History and Symptoms==
==History and Symptoms==
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===Common Symptoms===
===Common Symptoms===
Common [[symptoms]] in patients with primary amyloidosis include:<ref name="pmid24497558">{{cite journal |vauthors=Mahmood S, Palladini G, Sanchorawala V, Wechalekar A |title=Update on treatment of light chain amyloidosis |journal=Haematologica |volume=99 |issue=2 |pages=209–21 |date=February 2014 |pmid=24497558 |pmc=3912950 |doi=10.3324/haematol.2013.087619 |url=}}</ref>
Common [[symptoms]] of primary amyloidosis include:<ref name="pmid26161016">{{cite journal |vauthors=Lim AY, Lee JH, Jung KS, Gwag HB, Kim DH, Kim SJ, Lee GY, Kim JS, Kim HJ, Lee SY, Lee JE, Jeon ES, Kim K |title=Clinical features and outcomes of systemic amyloidosis with gastrointestinal involvement: a single-center experience |journal=Korean J. Intern. Med. |volume=30 |issue=4 |pages=496–505 |date=July 2015 |pmid=26161016 |pmc=4497337 |doi=10.3904/kjim.2015.30.4.496 |url=}}</ref><ref name="pmid23227278">{{cite journal |vauthors=Baker KR, Rice L |title=The amyloidoses: clinical features, diagnosis and treatment |journal=Methodist Debakey Cardiovasc J |volume=8 |issue=3 |pages=3–7 |date=2012 |pmid=23227278 |pmc=3487569 |doi= |url=}}</ref>
*[[Bleeding]] tendency
 
* Swelling of lower [[limbs]]
* [[Fatigue]]
* Frothy [[urine]]
* [[Weight loss]]
* [[Edema]]
 
*[[Abdominal pain]]
*[[Enlarged tongue]]


===Less Common Symptoms===
===Less Common Symptoms===
*Enlarged [[tongue]]  
Less common [[symptoms]] of amyloidosis include:<ref name="pmid10228037">{{cite journal |vauthors=Hamidi Asl K, Liepnieks JJ, Nakamura M, Benson MD |title=Organ-specific (localized) synthesis of Ig light chain amyloid |journal=J. Immunol. |volume=162 |issue=9 |pages=5556–60 |date=May 1999 |pmid=10228037 |doi= |url=}}</ref>
*[[Abdominal pain]]
 
*[[Hoarseness]]
*[[Gastrointestinal bleeding]]
*[[Diarrhea]]
*[[Diarrhea]]
*[[Peripheral neuropathy]] (nerve pain including [[numbness]] and [[tingling]])
*Paresthesias
*Gross [[hematuria]]
*Irritative [[urinary symptoms]]


== References ==
== References ==

Latest revision as of 15:32, 30 October 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[3]

Overview

Common symptoms of amyloidosis include abdominal pain, edema and enlarged tongue. Less common symptoms of amyloidosis include gastrointestinal bleeding, gross hematuria, hoarseness and paresthesias.

History and Symptoms

History

Patients with amyloidosis may have a positive history of:[1]

Common Symptoms

Common symptoms of primary amyloidosis include:[2][3]

Less Common Symptoms

Less common symptoms of amyloidosis include:[4]

References

  1. Mahmood S, Palladini G, Sanchorawala V, Wechalekar A (February 2014). "Update on treatment of light chain amyloidosis". Haematologica. 99 (2): 209–21. doi:10.3324/haematol.2013.087619. PMC 3912950. PMID 24497558.
  2. Lim AY, Lee JH, Jung KS, Gwag HB, Kim DH, Kim SJ, Lee GY, Kim JS, Kim HJ, Lee SY, Lee JE, Jeon ES, Kim K (July 2015). "Clinical features and outcomes of systemic amyloidosis with gastrointestinal involvement: a single-center experience". Korean J. Intern. Med. 30 (4): 496–505. doi:10.3904/kjim.2015.30.4.496. PMC 4497337. PMID 26161016.
  3. Baker KR, Rice L (2012). "The amyloidoses: clinical features, diagnosis and treatment". Methodist Debakey Cardiovasc J. 8 (3): 3–7. PMC 3487569. PMID 23227278.
  4. Hamidi Asl K, Liepnieks JJ, Nakamura M, Benson MD (May 1999). "Organ-specific (localized) synthesis of Ig light chain amyloid". J. Immunol. 162 (9): 5556–60. PMID 10228037.

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