Odynophagia natural history, complications and prognosis: Difference between revisions

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==Overview==
==Overview==
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
If left untreated, patients with odynophagia may progress to develop [[weight loss]], [[malnutrition]], and food aversion. Prognosis is generally excellent, and the mortality/survival rate of patients with odynophagia depend on the primary cause.
 
OR
 
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
 
OR
 
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
==Natural History, Complications, and Prognosis==
==Natural History, Complications, and Prognosis==


===Natural History===
===Natural History===
*The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
*If left untreated, patients with odynophagia may progress to develop [[weight loss]], [[malnutrition]], and food aversion.
*The symptoms of (disease name) typically develop ___ years after exposure to ___.
*However the causes of odynophagia have their own independent course of progression and complication. 
*If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].


===Complications===
===Complications===
*Common complications of [disease name] include:
*Common complications of odynophagia depend on the treatment and progress of primary disease, which may include:
**[Complication 1]
**[[Upper respiratory tract infection|'''URTI''']]: [[Lower respiratory tract infection|LRTI]], [[toxemia]], [[meningitis]], [[pneumonia]], [[otitis]], orbital infections, systemic infections, [[encephalitis]].
**[Complication 2]
**[[GERD|'''GERD''']]: [[Stricture]],[[weight loss]], [[Barrett's esophagus]], erosive esophagitis, [[esophageal ulcer]], [[Adenocarcinoma|esophageal adenocarcinoma]].
**[Complication 3]
**'''[[Tumor]]''': [[Metastasis]], narrowing of food passage, [[weight loss]], [[DVT]].
**'''Foreign body''': local inflammation, non invasive and invasive infections.
**'''[[Esophagitis]]''': [[Weight loss]], superimposed bacterial infections, [[stricture]].


===Prognosis===
===Prognosis===
*Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
*Prognosis is generally excellent, and the mortality/survival rate of patients with odynophagia depend on the primary cause.
*Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
**[[Tumors]]: Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. [[Adenocarcinoma]] has better prognosis compared to [[Squamous cell carcinoma|squamous cell cancers]].
*The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
**[[URTI]]: Prognosis is generally excellent. Viral URTI's have better outcomes compared to bacterial URTI's.
*[Subtype of disease/malignancy] is associated with the most favorable prognosis.
**[[Gastroesophageal reflux disease|GERD]]: Prognosis is generally good. If untreated 20% may develop esophageal strictures.<ref name="pmid10780569">{{cite journal| author=Sonnenberg A, El-Serag HB| title=Clinical epidemiology and natural history of gastroesophageal reflux disease. | journal=Yale J Biol Med | year= 1999 | volume= 72 | issue= 2-3 | pages= 81-92 | pmid=10780569 | doi= | pmc=2579001 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10780569  }}</ref>
*The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
**Foreign body: Prognosis is generally excellent, if foreign body is removed in a timely manner.
**[[Esophagitis]]: Prognosis is generally good. It depends mostly on the cause of esophageal inflammation. Viral infections recover earlier with less complications compared to [[autoimmune]], bacterial and chemical causes.


==References==
==References==

Latest revision as of 14:48, 26 March 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

If left untreated, patients with odynophagia may progress to develop weight loss, malnutrition, and food aversion. Prognosis is generally excellent, and the mortality/survival rate of patients with odynophagia depend on the primary cause.

Natural History, Complications, and Prognosis

Natural History

  • If left untreated, patients with odynophagia may progress to develop weight loss, malnutrition, and food aversion.
  • However the causes of odynophagia have their own independent course of progression and complication. 

Complications

Prognosis

  • Prognosis is generally excellent, and the mortality/survival rate of patients with odynophagia depend on the primary cause.
    • Tumors: Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. Adenocarcinoma has better prognosis compared to squamous cell cancers.
    • URTI: Prognosis is generally excellent. Viral URTI's have better outcomes compared to bacterial URTI's.
    • GERD: Prognosis is generally good. If untreated 20% may develop esophageal strictures.[1]
    • Foreign body: Prognosis is generally excellent, if foreign body is removed in a timely manner.
    • Esophagitis: Prognosis is generally good. It depends mostly on the cause of esophageal inflammation. Viral infections recover earlier with less complications compared to autoimmune, bacterial and chemical causes.

References

  1. ↑ Sonnenberg A, El-Serag HB (1999). "Clinical epidemiology and natural history of gastroesophageal reflux disease". Yale J Biol Med. 72 (2–3): 81–92. PMC 2579001. PMID 10780569.

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