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{{SI}}
{{Gonadoblastoma}}
{{CMG}} {{AE}} {{Ammu}}
{{CMG}}; {{AE}} {{Sahar}}
 
{{SK}} [[Gonadoblastomas]]; [[Gonadoblastomata]]
 
 
 
==[[Gonadoblastoma overview|Overview]]==
 
==[[Gonadoblastoma historical perspective|Historical Perspective]]==
 
==[[Gonadoblastoma classification|Classification]]==
 
==[[Gonadoblastoma pathophysiology|Pathophysiology]]==
 
==[[Gonadoblastoma causes|Causes]]==
 
==[[Gonadoblastoma differential diagnosis|Differentiating Gonadoblastoma from other Diseases]]==
 
==[[Gonadoblastoma epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Gonadoblastoma risk factors|Risk Factors]]==
 
==[[Gonadoblastoma screening|Screening]]==
 
==[[Gonadoblastoma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 
==Diagnosis==
[[Gonadoblastoma diagnostic study of choice|Diagnostic study of choice]] | [[Gonadoblastoma history and symptoms|History and Symptoms]] | [[Gonadoblastoma physical examination|Physical Examination]] | [[Gonadoblastoma laboratory findings|Laboratory Findings]] | [[Gonadoblastoma electrocardiogram|Electrocardiogram]] | [[Gonadoblastoma x ray|X-Ray Findings]] | [[Gonadoblastoma echocardiography and ultrasound|Echocardiography and Ultrasound]] | [[Gonadoblastoma CT scan|CT-Scan Findings]] | [[Gonadoblastoma MRI|MRI Findings]] | [[Gonadoblastoma other imaging findings|Other Imaging Findings]] | [[Gonadoblastoma other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Gonadoblastoma medical therapy|Medical Therapy]] | [[Gonadoblastoma surgery|Surgery]] | [[Gonadoblastoma primary prevention|Primary Prevention]] | [[Gonadoblastoma secondary prevention|Secondary Prevention]] | [[Gonadoblastoma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Gonadoblastoma future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
[[Gonadoblastoma case study one|Case #1]]
 
 
[[Category:Medicine]]


{{SK}} Gonadoblastomas; Gonadoblastomata
==Overview==
Gonadoblastoma was first discovered by Scully, in 1953. A gonadoblastoma is a complex [[neoplasm]] composed of a mixture of [[gonad]]al elements, such as large primordial [[germ cell]]s, immature [[Sertoli cell]]s or [[granulosa cell]]s of the [[sex cord]], and gonadal [[stromal cell]]s. Gonadoblastoma may be caused by either complete androgen insensitivity, pure gonadal dysgenesis or Swyer syndrome, mixed gonadal dysgenesis, Frasier syndrome, Denys-Drash syndrome, and 9p Partial monosomy. Gonadoblastoma must be differentiated from other diseases that cause ovarian tumors, such as 17-hydroxylase deficiency syndrome, 5-alpha-reductase deficiency, amenorrhea, congenital adrenal hyperplasia, hypospadias, and Meigs syndrome. Gonadoblastoma may also be diagnosed using chromosomal analysis. Surgery is the mainstay of therapy for gonadoblastoma.
==Historical Perspective==
*Gonadoblastoma was first discovered by Scully, in 1953.
==Pathophysiology==
*A gonadoblastoma is a complex [[neoplasm]] composed of a mixture of [[gonad]]al elements, such as large primordial [[germ cell]]s, immature [[Sertoli cell]]s or [[granulosa cell]]s of the [[sex cord]], and gonadal [[stromal cell]]s.<ref> Gonadoblstoma. Wikipedia (2016). https://en.wikipedia.org/wiki/Gonadoblastoma  Accessed on April 15, 2016</ref>
*Abnormal chromosomal [[karyotype]], gonadal [[dysgenesis]], and the presence of a [[Y chromosome]] has been associated with the development of gonadoblastoma.
==Causes==
* Gonadoblastoma may be caused by either complete androgen insensitivity, pure gonadal dysgenesis or Swyer syndrome, mixed gonadal dysgenesis, Frasier syndrome, Denys-Drash syndrome, and 9p Partial monosomy.
==Differentiating Gonadoblastoma from other Diseases==
*Gonadoblastoma must be differentiated from other diseases such as:
:*17-Hydroxylase Deficiency Syndrome
:*5-Alpha-Reductase Deficiency
:*Amenorrhea
:*Congenital Adrenal Hyperplasia
:*Genital Anomalies
:*Hypospadias
:*Pediatric Seminoma
:*Turner Syndrome
:*Meigs syndrome
=== Other Diagnostic Studies ===
*Gonadoblastoma may also be diagnosed using chromosomal analysis.
== Treatment ==
=== Surgery ===
*Surgery is the mainstay of therapy for gonadoblastoma.
*Surgical exploration via laparotomy and bilateral salpingo-oophorectomy (BSO) is the most common approach to the treatment of gonadoblastoma.
==References==
{{Reflist|2}}
[[Category:Oncology]]
[[Category:Oncology]]
[[Category:Gynecology]]
[[Category:Up-To-Date]]

Latest revision as of 06:33, 28 July 2020

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Overview

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Diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Synonyms and keywords: Gonadoblastomas; Gonadoblastomata


Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Gonadoblastoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic study of choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X-Ray Findings | Echocardiography and Ultrasound | CT-Scan Findings | MRI Findings | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1