Kaposi's sarcoma differential diagnosis: Difference between revisions
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| style="background:#F5F5F5;" align="center" | ↓ | | style="background:#F5F5F5;" align="center" | ↓ | ||
| style="background:#F5F5F5;" align="center" | ↓ | | style="background:#F5F5F5;" align="center" | ↓ | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" |Nl | ||
| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | | ||
* Hyperkeratosis, epidermal atrophy, vacuolar interface dermatitis | * [[Hyperkeratosis]], epidermal [[atrophy]], vacuolar interface [[dermatitis]] | ||
* Thickening of the basement membrane | * Thickening of the [[basement membrane]] | ||
* Superficial, perivascular, and perifollicular mononuclear cell inflammatory infiltrate | * Superficial, [[Perivascular cell|perivascular]], and perifollicular [[Monocyte|mononuclear cell]] inflammatory infiltrate | ||
| style="background:#F5F5F5;" align="center" | Clinical manifestations | | style="background:#F5F5F5;" align="center" | Clinical manifestations | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | | ||
* Raynaud phenomenon | * [[Raynaud's phenomenon|Raynaud phenomenon]] | ||
* Neuropsychiatric symptoms | * [[Neuropsychiatry|Neuropsychiatric]] symptoms | ||
* Pleural effusion | * [[Pleural effusion]] | ||
* Peptic ulcer | * [[Peptic ulcer|Peptic ulcer disease]] | ||
* Pericarditis | * [[Pericarditis]] | ||
* Myocarditis | * [[Myocarditis]] | ||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Pyogenic]] granuloma <ref name="pmid22434943">{{cite journal |vauthors=Kamal R, Dahiya P, Puri A |title=Oral pyogenic granuloma: Various concepts of etiopathogenesis |journal=J Oral Maxillofac Pathol |volume=16 |issue=1 |pages=79–82 |date=January 2012 |pmid=22434943 |pmc=3303528 |doi=10.4103/0973-029X.92978 |url=}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Pyogenic]] granuloma <ref name="pmid22434943">{{cite journal |vauthors=Kamal R, Dahiya P, Puri A |title=Oral pyogenic granuloma: Various concepts of etiopathogenesis |journal=J Oral Maxillofac Pathol |volume=16 |issue=1 |pages=79–82 |date=January 2012 |pmid=22434943 |pmc=3303528 |doi=10.4103/0973-029X.92978 |url=}}</ref> | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | | ||
* Trauma | * [[Physical trauma|Trauma]] | ||
* Hormonal influences | * Hormonal influences | ||
* Viruses | * [[Virus|Viruses]] | ||
* Cytogenetic clonal deletion abnormalities | * Cytogenetic clonal deletion abnormalities | ||
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| style="background:#F5F5F5;" align="center" | + | | style="background:#F5F5F5;" align="center" | + | ||
| style="background:#F5F5F5;" align="center" | Any age, usually in 20-30 years | | style="background:#F5F5F5;" align="center" | Any age, usually in 20-30 years | ||
| style="background:#F5F5F5;" align="center" | Painless red lesion | | style="background:#F5F5F5;" align="center" | | ||
* Painless red lesion | |||
* Lobular [[capillary hemangioma]] | |||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | + | | style="background:#F5F5F5;" align="center" | + | ||
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| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | Neutrophilic infiltration | | style="background:#F5F5F5;" align="center" | | ||
* Neutrophilic infiltration | |||
* [[Bleeding|Hemorrhage]] | |||
* [[Necrosis]] of the overlying [[Epidermis (skin)|epidermis]] | |||
| style="background:#F5F5F5;" align="center" | Clinical manifestation | | style="background:#F5F5F5;" align="center" | Clinical manifestation | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" |NA | ||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Benign lymphangioendothelioma <ref name="pmid10935645">{{cite journal |vauthors=Guillou L, Fletcher CD |title=Benign lymphangioendothelioma (acquired progressive lymphangioma): a lesion not to be confused with well-differentiated angiosarcoma and patch stage Kaposi's sarcoma: clinicopathologic analysis of a series |journal=Am. J. Surg. Pathol. |volume=24 |issue=8 |pages=1047–57 |date=August 2000 |pmid=10935645 |doi= |url=}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |Benign lymphangioendothelioma <ref name="pmid10935645">{{cite journal |vauthors=Guillou L, Fletcher CD |title=Benign lymphangioendothelioma (acquired progressive lymphangioma): a lesion not to be confused with well-differentiated angiosarcoma and patch stage Kaposi's sarcoma: clinicopathologic analysis of a series |journal=Am. J. Surg. Pathol. |volume=24 |issue=8 |pages=1047–57 |date=August 2000 |pmid=10935645 |doi= |url=}}</ref> | ||
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| style="background:#F5F5F5;" align="center" | + | | style="background:#F5F5F5;" align="center" | + | ||
| style="background:#F5F5F5;" align="center" | Any ages, median age is 50 years | | style="background:#F5F5F5;" align="center" | Any ages, median age is 50 years | ||
| style="background:#F5F5F5;" align="center" | single, slowly expanding patch, plaque, or nodule | | style="background:#F5F5F5;" align="center" | | ||
* single, slowly expanding patch, [[plaque]], or [[Nodule (medicine)|nodule]] | |||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
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| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | Thin-walled endothelial-lined spaces that are interspersed between strands of collagen | | style="background:#F5F5F5;" align="center" | | ||
| style="background:#F5F5F5;" align="center" | | * Thin-walled endothelial-lined spaces that are interspersed between strands of [[collagen]] | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" |[[Biopsy]] | ||
| style="background:#F5F5F5;" align="center" |NA | |||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Cavernous [[hemangioma]] <ref name="pmid229814">{{cite journal |vauthors=Goldberg RE, Pheasant TR, Shields JA |title=Cavernous hemangioma of the retina. A four-generation pedigree with neurocutaneous manifestations and an example of bilateral retinal involvement |journal=Arch. Ophthalmol. |volume=97 |issue=12 |pages=2321–4 |date=December 1979 |pmid=229814 |doi= |url=}}</ref> | | style="background: #DCDCDC; padding: 5px; text-align: center;" |Cavernous [[hemangioma]] <ref name="pmid229814">{{cite journal |vauthors=Goldberg RE, Pheasant TR, Shields JA |title=Cavernous hemangioma of the retina. A four-generation pedigree with neurocutaneous manifestations and an example of bilateral retinal involvement |journal=Arch. Ophthalmol. |volume=97 |issue=12 |pages=2321–4 |date=December 1979 |pmid=229814 |doi= |url=}}</ref> | ||
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| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | Usually in third to fifth decades of life. | | style="background:#F5F5F5;" align="center" | Usually in third to fifth decades of life. | ||
| style="background:#F5F5F5;" align="center" | Painless, slowly progressive protrusion or bulging of their globe | | style="background:#F5F5F5;" align="center" | | ||
* Painless, slowly progressive protrusion or bulging of their globe | |||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
| style="background:#F5F5F5;" align="center" | – | | style="background:#F5F5F5;" align="center" | – | ||
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| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | Nl | | style="background:#F5F5F5;" align="center" | Nl | ||
| style="background:#F5F5F5;" align="center" | Engorged vascular channels, which are tightly knit and separated by fibrous septae | | style="background:#F5F5F5;" align="center" | | ||
* Engorged vascular channels, which are tightly knit and separated by [[Fiber|fibrous]] septae | |||
| style="background:#F5F5F5;" align="center" | Clinical manidestation | | style="background:#F5F5F5;" align="center" | Clinical manidestation | ||
| style="background:#F5F5F5;" align="center" | | | style="background:#F5F5F5;" align="center" | | ||
* Diplopia | * [[Diplopia]] | ||
* Decreased color vision | * Decreased [[color vision]] | ||
* Visual field deficits | * [[Visual field loss|Visual field deficits]] | ||
|- | |- | ||
| | |Diseases | ||
| | |Etiology | ||
| | |Congenital | ||
| | |Acquired | ||
| | |Demography | ||
!Appearance | |||
!Fever | |||
!Bleeding | |||
!BP | |||
!Hepatosplenomegaly | |||
!Lymphadenopathy | |||
!Other | |||
!WBC | |||
!Hb | |||
!Plt | |||
| | |LFT | ||
| | |ESR/CRP | ||
| | |Histopathology | ||
| | |Gold standard diagnosis | ||
| | |Associated findings | ||
|} | |} | ||
Revision as of 17:40, 4 October 2018
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Farima Kahe M.D. [2] Haytham Allaham, M.D. [3]
Kaposi's sarcoma Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Kaposi's sarcoma differential diagnosis On the Web |
American Roentgen Ray Society Images of Kaposi's sarcoma differential diagnosis |
Risk calculators and risk factors for Kaposi's sarcoma differential diagnosis |
Overview
Kaposi's sarcoma must be differentiated from other diseases that cause similar cutaneous, pulmonary, and gastrointestinal involvement, such as bacillary angiomatosis, AIDS-related lymphoma, and seborrheic keratosis.
Differentiating Kaposi's Sarcoma from other Diseases
- Kaposi's sarcoma must be differentiated from other diseases that cause similar cutaneous, pulmonary, and gastrointestinal involvement.[1][2][3]
Diseases | Etiology | Congenital | Acquired | Demography | Clinical manifestations | Lab findings | Gold standard diagnosis | Associated findings | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Symptoms | Signs | CBC | LFT | ESR/CRP | Histopathology | ||||||||||||||
Appearance | Fever | Bleeding | BP | Hepatosplenomegaly | Lymphadenopathy | Other | WBC | Hb | Plt | ||||||||||
Bacillary angiomatosis [4] | – | + | Any age, usually between 20 -50 years | Solitary or multiple red, purple, flesh-colored, or colorless papules | ± | ± | Nl | – | – | Nl | Nl | Nl | Nl | Nl |
|
Clinical manifestation | |||
Arteriovenous malformation [5] |
|
+ | – | Any age | Nl | – | + | Nl | – | – | Nl | Nl | Nl | Nl | Nl | NA | Imaging | ||
Acroangiodermatitis[6] |
|
– | – | Any age, more in males | Purplish-blue to brown papules and plaques | – | – | Nl | – | – |
|
Nl | Nl | Nl | Nl | Nl |
|
Clinical manifesttations | |
Angiosarcoma [7] |
|
– | – | Adults, more in males | Enlarging bruise, a blue-black nodule, or an unhealed ulceration | – | – | Nl | – | – | – | Nl | ↓ | ↓ | Nl | Nl |
|
Biopsy | NA |
Diseases | Etiology | Congenital | Acquired | Demography | Appearance | Fever | Bleeding | BP | Hepatosplenomegaly | Lymphadenopathy | Other | WBC | Hb | Plt | LFT | ESR/CRP | Histopathology | Gold standard diagnosis | Associated findings |
Masson's hemangioma [8] |
|
– | – | Rare |
|
– | – | Nl | – | – | – | Nl | Nl | Nl | Nl | Nl |
|
Biopsy | |
Seborrheic keratosis [9] |
|
+ | – | Any age |
|
– | – | Nl | – | – | – | Nl | Nl | Nl | Nl | Nl |
|
Clinical manifestations |
|
Systemic lupus erythematosus (SLE) [10] |
|
– | – | More common in female, typically in the 20 to 30 years |
|
± | - | ↑ | ± | ± | ↑ | ↓ | ↓ | Nl | Nl |
|
Clinical manifestations | ||
Pyogenic granuloma [11] |
|
+ | + | Any age, usually in 20-30 years |
|
– | + | Nl | – | – | – | Nl | Nl | Nl | Nl | Nl |
|
Clinical manifestation | NA |
Benign lymphangioendothelioma [12] |
|
– | + | Any ages, median age is 50 years | – | – | Nl | – | – | – | Nl | Nl | Nl | Nl | Nl |
|
Biopsy | NA | |
Cavernous hemangioma [13] |
|
– | – | Usually in third to fifth decades of life. |
|
– | – | Nl | – | – | – | Nl | Nl | Nl | Nl | Nl |
|
Clinical manidestation |
|
Diseases | Etiology | Congenital | Acquired | Demography | Appearance | Fever | Bleeding | BP | Hepatosplenomegaly | Lymphadenopathy | Other | WBC | Hb | Plt | LFT | ESR/CRP | Histopathology | Gold standard diagnosis | Associated findings |
References
- ↑ Kaposi's Sarcoma. Radiopaedia (2015) http://radiopaedia.org/articles/kaposi-sarcoma Accessed on January, 19 2016
- ↑ Libre Pathology. Kaposi's sarcoma (2015) http://librepathology.org/wiki/index.php/File:Kaposi_sarcoma_low_intermed_mag.jpg Accessed on January, 19 2016
- ↑ Kaposi's Sarcoma. PathologyOutlines (2015) http://www.pathologyoutlines.com/topic/skintumornonmelanocytickaposisarcoma.html Accessed on January, 19 2015
- ↑ Tappero JW, Perkins BA, Wenger JD, Berger TG (July 1995). "Cutaneous manifestations of opportunistic infections in patients infected with human immunodeficiency virus". Clin. Microbiol. Rev. 8 (3): 440–50. PMC 174635. PMID 7553576.
- ↑ Whitehead KJ, Smith MC, Li DY (February 2013). "Arteriovenous malformations and other vascular malformation syndromes". Cold Spring Harb Perspect Med. 3 (2): a006635. doi:10.1101/cshperspect.a006635. PMC 3552339. PMID 23125071.
- ↑ Lugović L, Pusić J, Situm M, Buljan M, Bulat V, Sebetić K, Soldo-Belić A (2007). "Acroangiodermatitis (pseudo-Kaposi sarcoma): three case reports". Acta Dermatovenerol Croat. 15 (3): 152–7. PMID 17868541.
- ↑ Barttelbort SW, Stahl R, Ariyan S (July 1989). "Cutaneous angiosarcoma of the face and scalp". Plast. Reconstr. Surg. 84 (1): 55–9. PMID 2734404.
- ↑ Park KK, Won YS, Yang JY, Choi CS, Han KY (July 2012). "Intravascular Papillary Endothelial Hyperplasia (Masson tumor) of the Skull : Case Report and Literature Review". J Korean Neurosurg Soc. 52 (1): 52–4. doi:10.3340/jkns.2012.52.1.52. PMC 3440504. PMID 22993679.
- ↑ Noiles K, Vender R (2008). "Are all seborrheic keratoses benign? Review of the typical lesion and its variants". J Cutan Med Surg. 12 (5): 203–10. doi:10.2310/7750.2008.07096. PMID 18845088.
- ↑ Uva L, Miguel D, Pinheiro C, Freitas JP, Marques Gomes M, Filipe P (2012). "Cutaneous manifestations of systemic lupus erythematosus". Autoimmune Dis. 2012: 834291. doi:10.1155/2012/834291. PMC 3410306. PMID 22888407.
- ↑ Kamal R, Dahiya P, Puri A (January 2012). "Oral pyogenic granuloma: Various concepts of etiopathogenesis". J Oral Maxillofac Pathol. 16 (1): 79–82. doi:10.4103/0973-029X.92978. PMC 3303528. PMID 22434943.
- ↑ Guillou L, Fletcher CD (August 2000). "Benign lymphangioendothelioma (acquired progressive lymphangioma): a lesion not to be confused with well-differentiated angiosarcoma and patch stage Kaposi's sarcoma: clinicopathologic analysis of a series". Am. J. Surg. Pathol. 24 (8): 1047–57. PMID 10935645.
- ↑ Goldberg RE, Pheasant TR, Shields JA (December 1979). "Cavernous hemangioma of the retina. A four-generation pedigree with neurocutaneous manifestations and an example of bilateral retinal involvement". Arch. Ophthalmol. 97 (12): 2321–4. PMID 229814.