Gem-associated protein 7: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Gem-associated protein 7''' is a [[protein]] that in humans is encoded by the ''GEMIN7'' [[gene]].<ref name="pmid12065586">{{cite journal | vauthors = Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G | title = Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex | journal = The Journal of Biological Chemistry | volume = 277 | issue = 35 | pages = 31957–62 | date = Aug 2002 | pmid = 12065586 | pmc = | doi = 10.1074/jbc.M203478200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79760| accessdate = }}</ref>The gem-associated proteins are those found in the [[Cell nucleus#Cajal bodies and gems|gems of Cajal bodies]].
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_GEMIN7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1y96.
| PDB = {{PDB2|1y96}}
| Name = Gem (nuclear organelle) associated protein 7
| HGNCid = 20045
| Symbol = GEMIN7
| AltSymbols =; SIP3
| OMIM = 607419
| ECnumber = 
| Homologene = 11668
| MGIid = 1916981
| GeneAtlas_image1 = PBB_GE_GEMIN7_219085_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016604 |text = nuclear body}}
| Process = {{GNF_GO|id=GO:0000387 |text = spliceosomal snRNP biogenesis}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 79760
    | Hs_Ensembl = ENSG00000142252
    | Hs_RefseqProtein = NP_001007270
    | Hs_RefseqmRNA = NM_001007269
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 50274358
    | Hs_GenLoc_end = 50286622
    | Hs_Uniprot = Q9H840
    | Mm_EntrezGene = 69731
    | Mm_Ensembl = ENSMUSG00000044709
    | Mm_RefseqmRNA = NM_027189
    | Mm_RefseqProtein = NP_081465
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 18723471
    | Mm_GenLoc_end = 18731865
    | Mm_Uniprot = Q9CWY4
  }}
}}
'''Gem (nuclear organelle) associated protein 7''', also known as '''GEMIN7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79760| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear &quot;gems&quot; (Gemini of [[Cajal body|Cajal bodies]]), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear &quot;gems&quot; (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79760| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
Gem-associated protein 7 has been shown to [[Protein-protein interaction|interact]] with [[SMN1]]<ref name=pmid12065586/><ref name=pmid11748230>{{cite journal | vauthors = Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G | title = Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7540–5 | date = Mar 2002 | pmid = 11748230 | doi = 10.1074/jbc.M110141200 }}</ref> and [[Gem-associated protein 6]].<ref name=pmid12065586/><ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | display-authors = 6 | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Carissimi C, Saieva L, Gabanella F, Pellizzoni L | title = Gemin8 is required for the architecture and function of the survival motor neuron complex | journal = The Journal of Biological Chemistry | volume = 281 | issue = 48 | pages = 37009–16 | date = Dec 2006 | pmid = 17023415 | doi = 10.1074/jbc.M607505200 }}
| citations =
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Carissimi C, Saieva L, Gabanella F, Pellizzoni L |title=Gemin8 is required for the architecture and function of the survival motor neuron complex. |journal=J. Biol. Chem. |volume=281 |issue= 48 |pages= 37009-16 |year= 2007 |pmid= 17023415 |doi= 10.1074/jbc.M607505200 }}
* {{cite journal | vauthors = Grimmler M, Otter S, Peter C, Müller F, Chari A, Fischer U | title = Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization | journal = Human Molecular Genetics | volume = 14 | issue = 20 | pages = 3099–111 | date = Oct 2005 | pmid = 16159890 | doi = 10.1093/hmg/ddi343 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Grimmler M, Otter S, Peter C, ''et al.'' |title=Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization. |journal=Hum. Mol. Genet. |volume=14 |issue= 20 |pages= 3099-111 |year= 2006 |pmid= 16159890 |doi= 10.1093/hmg/ddi343 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Baccon J, Pellizzoni L, Rappsilber J, ''et al.'' |title=Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31957-62 |year= 2002 |pmid= 12065586 |doi= 10.1074/jbc.M203478200 }}
}}
{{refend}}
{{refend}}


{{PDB Gallery|geneid=79760}}
{{Nucleus}}
{{gene-19-stub}}
{{gene-19-stub}}
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Latest revision as of 02:15, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene.[1][2]The gem-associated proteins are those found in the gems of Cajal bodies.

Function

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene.[2]

Interactions

Gem-associated protein 7 has been shown to interact with SMN1[1][3] and Gem-associated protein 6.[1][4]

References

  1. ↑ 1.0 1.1 1.2 Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
  2. ↑ 2.0 2.1 "Entrez Gene: GEMIN7 gem (nuclear organelle) associated protein 7".
  3. ↑ Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
  4. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

  • Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex". The Journal of Biological Chemistry. 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
  • Grimmler M, Otter S, Peter C, Müller F, Chari A, Fischer U (Oct 2005). "Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization". Human Molecular Genetics. 14 (20): 3099–111. doi:10.1093/hmg/ddi343. PMID 16159890.
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