Jump to navigation Jump to search
Clinical data
  • AU: B2
  • US: B (No risk in non-human studies)
Routes of
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding45%
Elimination half-life1.1 hours
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Molar mass384.429 g/mol

WikiDoc Resources for Ticarcillin


Most recent articles on Ticarcillin

Most cited articles on Ticarcillin

Review articles on Ticarcillin

Articles on Ticarcillin in N Eng J Med, Lancet, BMJ


Powerpoint slides on Ticarcillin

Images of Ticarcillin

Photos of Ticarcillin

Podcasts & MP3s on Ticarcillin

Videos on Ticarcillin

Evidence Based Medicine

Cochrane Collaboration on Ticarcillin

Bandolier on Ticarcillin

TRIP on Ticarcillin

Clinical Trials

Ongoing Trials on Ticarcillin at Clinical Trials.gov

Trial results on Ticarcillin

Clinical Trials on Ticarcillin at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Ticarcillin

NICE Guidance on Ticarcillin


FDA on Ticarcillin

CDC on Ticarcillin


Books on Ticarcillin


Ticarcillin in the news

Be alerted to news on Ticarcillin

News trends on Ticarcillin


Blogs on Ticarcillin


Definitions of Ticarcillin

Patient Resources / Community

Patient resources on Ticarcillin

Discussion groups on Ticarcillin

Patient Handouts on Ticarcillin

Directions to Hospitals Treating Ticarcillin

Risk calculators and risk factors for Ticarcillin

Healthcare Provider Resources

Symptoms of Ticarcillin

Causes & Risk Factors for Ticarcillin

Diagnostic studies for Ticarcillin

Treatment of Ticarcillin

Continuing Medical Education (CME)

CME Programs on Ticarcillin


Ticarcillin en Espanol

Ticarcillin en Francais


Ticarcillin in the Marketplace

Patents on Ticarcillin

Experimental / Informatics

List of terms related to Ticarcillin

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Ticarcillin is a carboxypenicillin. It is almost invariably sold and used in combination with clavulanate as Timentin®. Because it is a penicillin, it also falls within the larger class of beta-lactam antibiotics. Its main clinical use is as an injectable antibiotic for the treatment of gram negative bacteria, in particular, Pseudomonas aeruginosa.

Chemically, ticarcillin is C15H16N2O6S2 (CAS number 34787-01-4). It is provided as a white or pale yellow powder. It is highly soluble in water, but should only be dissolved immediately before use to prevent degradation.

Mechanism of Action

Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis when the bacteria tries to divide, causing death.

Ticarcillin is similar to penicilin in that it contains a β-lactam ring. This can lead to resistance in bacteria containing β-lactamase, which cleaves the ring and inactivates it. It is often paired with a β-lactamase inhibitor such as clavulanic acid. Because of ticarcillins similarties to penicillin, including the β-lactam ring, it can cause similar allergic reactions in patients sensitive to penicillin.

Other Uses

In molecular biology, ticarcillin is used to as an alternative to ampicillin to test the uptake of marker genes into bacteria. It prevents the appearance of satellite colonies that occur when ampicillin breaks down in the media. It is also used in plant molecular biology to kill agrobacterium, which is used to deliver genes to plant cells.

Dosing and Posology

Ticarcillin is not absorbed orally, and therefore must be given by intravenous or intramuscular injection. The usual adult dose of Timentin is 3.5g four times a day.

Trade Names and Preparations

  • Ticarcillin: Ticar® (Formerly marketed by Beecham, then SmithKline Beecham until 1999, when it merged with Glaxo to form GlaxoSmithKline; no longer available in the UK. US distribution ceased in 2004. Ticar was replaced by Timentin.)

  • Ticarcillin/clavulanate: Timentin® (UK and US, marketed by Beecham, then GlaxoSmithKline).

Template:WikiDoc Sources