Sandbox/0009

History

Review all medications Antihypertensives can cause significant hypotension, especially in the setting of volume depletion or over-diuresis. Anaphylaxis should be considered if the patient recently started on a new drug and presented with respiratory distress. Findings suggestive of hypovolemic shock Abdominal pain Diarrhea Dry skin, mucosa, axillae Hematemesis Hematochezia Melena Postoperative Trauma Vomiting Findings suggestive of cardiogenic shock Chest pain Dyspnea Palpitations Findings suggestive of distributive shock Altered mental status Chills Dyspnea Dysuria Fatigue Fever Flushing Headache Hematuria Malaise Myalgias Photophobia Productive cough Rash Tachycardia Tachypnea

Physical Examination

Vital signs Temperature Fever may suggest sepsis or anaphylactic reaction related to transfusion. Hypothermia may be associated with sepsis, adrenal crisis, or myxedema. Pulse Bradycardia or tachycardia can either be a primary or secondary process. Pulsus paradoxus may be seen in cardiac tamponade, pulmonary embolism, hemorrhagic shock, or tension pneumothorax. Pulsus alternans may be seen in heart failure, severe aortic insufficiency, or hypovolemic shock. Respiration Tachypnea commonly occurs in pneumothorax, sepsis, and cardiogenic shock. Hypopnea may be seen in narcotic or sedative overdose. Blood pressure Confirm arterial hypotension by checking blood pressure in both arms manually. Arterial line may be considered. Postural hypotension suggests volume depletion or autonomic dysfunction. Do not test orthostatic hypotension in hypotensive patients. Mental status Altered mental status may indicate inadequate perfusion to vital organs or use of sedatives or narcotics. Cutaneous Decreased skin turgor and dry mucous membrane signify dehydration. Cool extremities, clammy and mottled skin, peripheral cyanosis, and delayed capillary refill are commonly noted in cardiogenic shock and hypovolemic shock, whereas warm and moist skin may represent hyperdynamic phase of septic shock. Extensive burns and severe trauma may be evident on inspection and are associated with significant fluid loss. Hyperpigmentation may be an indicator of adrenal crisis. Neck Elevated jugular venous pressure (JVP) correlates with increased left ventricular end diastolic pressure (LVEDP) and decreased left ventricular ejection fraction (LVEF). Jugular venous distention or elevated JVP typically occurs in: Heart failure Tricuspid stenosis Pulmonary hypertension Superior vena cava obstruction Constrictive pericarditis Cardiac tamponade Kussmaul's sign Constrictive pericarditis Restrictive cardiomyopathy Tricuspid stenosis Superior vena cava obstruction Right ventricular infarction Abdominojugular reflux (a positive abdominojugular reflux correlates with a PCWP of 15 mmHg or greater) Cardiac tamponade Constrictive pericarditis Tricuspid insufficiency Inferior vena cava obstruction Heart failure (except for pure backward left-sided heart failure) Jugular venous pressure waveform Blunted y descent suggests cardiac tamponade or tricuspid stenosis. Steep y descent suggests constrictive pericarditis or severe tricuspid insufficiency. Cardiovascular Decrescendo early systolic murmur Acute severe mitral regurgitation Third heart sound (S3) Heart failure Pansystolic murmur along lower left sternal border with palpable thrill Ventricular septal defect Pericardial friction rubs Pericarditis Distant, muffled heart sounds Cardiac tamponade Pulmonary Tracheal deviation Tension pneumothorax Stridor and wheezing Anaphylaxis Acute exacerbation of chronic obstructive pulmonary disease Rales Anaphylaxis Pneumonia Heart failure Chest percussion may aid in the diagnosis of tension pneumothorax, pleural effusions, and pneumonia Abdominal Grey Turner's sign Acute pancreatitis Blunt abdominal trauma Retroperitoneal hemorrhage Ruptured abdominal aortic aneurysm Ruptured ectopic pregnancy Cullen's sign Acute pancreatitis Blunt abdominal trauma Ruptured abdominal aortic aneurysm Ruptured ectopic pregnancy Hepatomegaly Inferior vena cava obstruction Heart failure Rebound tenderness with absent bowel sounds Sepsis due to Intraabdominal infection Ischemic colitis Gastrointestinal hemorrhage Pulsatile mass Abdominal aortic aneurysm Rectal Bright red blood or melena Gastrointestinal hemorrhage Diminished sphincter tone Spinal cord injury Extremities Digital clubbing Heart failure Edema Heart failure Erythema at the site of venous access Catheter-associated infection Pelvic girdle pain or instability Pelvic fracture Genitals Perform a pelvic examination in women of childbearing age to rule out ectopic pregnancy or pelvic inflammatory disease. Neurologic Agitation or delirium Poor cerebral perfusion Meningeal signs (nuchal rigidity, Brudzinski's sign, and Kernig's sign Meningitis

Laboratory Findings

Complete blood count In acute blood loss, hemoglobin and hematocrit levels may remain normal until volume repletion. Leukocytosis with or without a left shift of neutrophils suggests sepsis. Thrombocytopenia with alterations in coagulation panel indicates disseminated intravascular coagulation (DIC), which may be a complication of sepsis. Electrolytes Decreased bicarbonate levels may be the primary deficit in metabolic acidosis or the compensatory change in respiratory alkalosis. Hyperkalemia due to transcellular shift is commonly associated with metabolic acidosis. Coagulation panel (PT, PTT, INR, etc.) Abnormalities in coagulation panel may be caused by disseminated intravascular coagulation (DIC), over-anticoagulation, or hepatic failure. Cardiac markers Check troponin and CK-MB levels when suspecting myocardial infarction. Elevation in cardiac markers may be associated with both cardiac and extracardiac etiologies. Liver function Increased levels of conjugated bilirubin, alkaline phosphatase, and hepatic aminotransferases are typically seen in ischemic hepatitis ("shock liver") due to cardiogenic shock. Renal function Prerenal azotemia and/or acute tubular necrosis may be associated with conditions of hypovolemia or reduced cardiac output. Oliguria (urine output <0.5 mL/kg/h) is usually evident. Lactate Hyperlactatemia generally reflects the development of anaerobic metabolism in hypoperfused tissue and/or imparied hepatic clearance. Lactate level could decrease within hours with effective therapy. Arterial blood gas Lactic acidosis may be an indicator of tissue hypoperfusion typically seen in septic shock. Combined acid-base disorders are fequently encountered in different stages of shock. Severe acidosis could blunt the effectiveness of vasopressors and potentiate the development of arrhythmias. Cultures Samples of blood, urine, and/or sputum should be sent for culture before administering antibiotics if sepsis is concerned. Nasogastric aspirate A negative nasogastric aspirate does not rule out upper gastrointestinal bleeding. Pregnancy test A pregnancy test should be performed on hypotensive women of childbearing age presenting with lower abdominal pain.

Radiographic Findings

Chest radiograph may aid in establishing diagnosis in the following conditions: Aortic dissection Cardiac tamponade Pneumonia complicating septic shock Pulmonary edema complicating cardiogenic shock Tension pneumothorax CT scan may aid in directing management in the following conditions: Occult internal hemorrhage Pulmonary embolism

Hemodynamic Profiles and Echocardiography Findings

Type of Shock Etiology CO SVR PCWP CVP SVO2 Echocardiographic Findings Cardiogenic Acute Ventricular Septal Defect ↓↓ ↑ N — ↑ ↑↑ ↑ — ↑↑ Large ventricles with poor contractility Acute Mitral Regurgitation ↓↓ ↑ ↑↑ ↑ — ↑↑ ↓ Myocardial Dysfunction ↓↓ ↑ ↑↑ ↑↑ ↓ RV Infarction ↓↓ ↑ N — ↓ ↑↑ ↓ Dilated RV, small LV, abnormal wall motions Obstructive Pulmonary Embolism ↓↓ ↑ N — ↓ ↑↑ ↓ Dilated RV, small LV Cardiac Tamponade ↓ — ↓↓ ↑ ↑↑ ↑↑ ↓ Pericardial effusion, small ventricles, dilated inferior vena cava Distributive Septic Shock N — ↑↑ ↓ — ↓↓ N — ↓ N — ↓ ↑ — ↑↑ Normal cardiac chambers with preserved contractility Anaphylactic Shock N — ↑↑ ↓ — ↓↓ N — ↓ N — ↓ ↑ — ↑↑ Hypovolemic Volume Depletion ↓↓ ↑ ↓↓ ↓↓ ↓ Small cardiac chambers with normal or high contractility