Primary lymphoma of the bone

Jump to: navigation, search

WikiDoc Resources for Primary lymphoma of the bone

Articles

Most recent articles on Primary lymphoma of the bone

Most cited articles on Primary lymphoma of the bone

Review articles on Primary lymphoma of the bone

Articles on Primary lymphoma of the bone in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Primary lymphoma of the bone

Images of Primary lymphoma of the bone

Photos of Primary lymphoma of the bone

Podcasts & MP3s on Primary lymphoma of the bone

Videos on Primary lymphoma of the bone

Evidence Based Medicine

Cochrane Collaboration on Primary lymphoma of the bone

Bandolier on Primary lymphoma of the bone

TRIP on Primary lymphoma of the bone

Clinical Trials

Ongoing Trials on Primary lymphoma of the bone at Clinical Trials.gov

Trial results on Primary lymphoma of the bone

Clinical Trials on Primary lymphoma of the bone at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Primary lymphoma of the bone

NICE Guidance on Primary lymphoma of the bone

NHS PRODIGY Guidance

FDA on Primary lymphoma of the bone

CDC on Primary lymphoma of the bone

Books

Books on Primary lymphoma of the bone

News

Primary lymphoma of the bone in the news

Be alerted to news on Primary lymphoma of the bone

News trends on Primary lymphoma of the bone

Commentary

Blogs on Primary lymphoma of the bone

Definitions

Definitions of Primary lymphoma of the bone

Patient Resources / Community

Patient resources on Primary lymphoma of the bone

Discussion groups on Primary lymphoma of the bone

Patient Handouts on Primary lymphoma of the bone

Directions to Hospitals Treating Primary lymphoma of the bone

Risk calculators and risk factors for Primary lymphoma of the bone

Healthcare Provider Resources

Symptoms of Primary lymphoma of the bone

Causes & Risk Factors for Primary lymphoma of the bone

Diagnostic studies for Primary lymphoma of the bone

Treatment of Primary lymphoma of the bone

Continuing Medical Education (CME)

CME Programs on Primary lymphoma of the bone

International

Primary lymphoma of the bone en Espanol

Primary lymphoma of the bone en Francais

Business

Primary lymphoma of the bone in the Marketplace

Patents on Primary lymphoma of the bone

Experimental / Informatics

List of terms related to Primary lymphoma of the bone

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: John Fani Srour, M.D.; Maria Fernanda Villarreal, M.D. [2]

Synonyms and Keywords: PLB; Reticulum cell lymphoma

Overview

Primary lymphoma of the bone (also known as "PLB") is an uncommon malignancy that accounts for less than 5% of all primary bone tumors. The majority of cases are of the non-Hodgkin type; Hodgkin disease accounting for only 6% of the cases. Primary lymphoma of the bone was first discovered by Parker and Jackson in 1939. The pathogenesis of primary lymphoma of the bone is characterized by excessive osteoclast activation. Primary lymphoma of the bone is commonly located in bone marrow, axial skeleton, or femur (most common). Primary lymphoma of the bone may be classified according to location into solitary, multifocal, distant, and visceral subtypes. Mutations in BCL2 and BCL6 genes have been associated with the development of primary lymphoma of the bone. Primary lymphoma of the bone is rare; the prevalence of primary lymphoma of the bone is approximately 0.01 per 100,000 individuals worldwide. Primary lymphoma of the bone is more commonly observed among middle aged adults and elderly patients. MRI is the imaging modality of choice for primary lymphoma of the bone. The mainstay of therapy for primary lymphoma of the bone is chemotherapy.

Historical Perspective

Primary lymphoma of the bone was first discovered by Parker and Jackson in 1939.[1]

Classification

Primary lymphoma of the bone may be classified according to location into 4 groups:[2]

Pathophysiology

  • Mutations in BCL2 and BCL6 have been associated with the development of primary lymphoma of the bone.
    • Fish flesh appearance of lymphoma
    • Extraosseous extension and indistinct margins

Causes

There are no established causes for primary lymphoma of the bone.

Differentiating Primary Lymphoma of the Bone from Other Diseases

Primary lymphoma of the bone must be differentiated from other diseases that cause bone pain, fever, and limited range of motion such as:[2]

Epidemiology and Demographics

  • Primary lymphoma of the bone accounts for less than 5% of all primary bone tumors.
  • The prevalence of primary lymphoma of the bone is approximately 0.01 per 100,000 individuals worldwide.
  • Primary lymphoma of the bone is more commonly observed among patients aged 50 to 70 years old.
  • Primary lymphoma of the bone affects men more frequently than women.
  • There is no racial predilection for primary lymphoma of the bone.

Risk Factors

The most common risk factor in the development of primary lymphoma of the bone is previous exposure to radiation.[2]

Screening

There is insufficient evidence to recommend routine screening for primary lymphoma of the bone.

Natural History, Complications, and Prognosis

  • The prognosis of primary lymphoma of the bone is generally good; the 5-year survival rate of patients with primary lymphoma of the bone is commonly >80%.[1]

Diagnosis

Diagnostic Study of Choice

MRI is the imaging modality of choice for the diagnosis of primary lymphoma of the bone.

History and Symptoms

Symptoms of primary lymphoma of the bone may include the following:[2]

Physical Examination

Patients with primary lymphoma of the bone usually appear pale or malnourished. Physical examination may be remarkable for:

Laboratory Findings

There are no specific laboratory findings associated with primary lymphoma of the bone. In some cases, non-specific findings may include:[2]

  • Elevated LDH
  • Elevated β2 microglobulin

Electrocardiogram

There are no ECG findings associated with primary lymphoma of the bone.

X-ray

On conventional radiograph, the following non-specific findings of primary lymphoma of the bone may be found:[2]

  • Solitary metadiaphyseal lesion
  • Layered periosteal reaction
  • Affected bone may be normal or affected by lytic, sclerotic or mixed pattern
  • A lytic pattern with permeative bone destruction and a wide zone of transition

Echocardiography or Ultrasound

There are no echocardiography/ultrasound findings associated with primary lymphoma of the bone.

CT scan

There are no CT scan findings associated with primary lymphoma of the bone.

MRI

On MRI, findings of primary lymphoma of the bone include:

Other Imaging Findings

There are no other imaging findings associated with primary lymphoma of the bone.

Other Diagnostic Studies

There are no other diagnostic studies associated with primary lymphoma of the bone.

Treatment

Medical Therapy

The mainstay of therapy for primary lymphoma of the bone is chemotherapy combined with radiotherapy. Response to chemotherapy or radiotherapy can be monitored with imaging studies.

Surgery

Surgical intervention is not recommended among patients with primary lymphoma of the bone.

Primary Prevention

There are no established measures for the primary prevention of primary lymphoma of the bone.

Secondary Prevention

There are no established measures for the secondary prevention of primary lymphoma of the bone.

References

  1. 1.0 1.1 Choi JY, Hahn JS, Suh CO, Yang WI (2002). "Primary lymphoma of bone--survival and prognosis". Korean J. Intern. Med. 17 (3): 191–7. PMC 4531681. PMID 12298430.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Primary lymphoma of the bone. Radiopedia. http://radiopaedia.org/articles/primary-bone-lymphoma Accessed on May 1st 2016
  3. 3.0 3.1 3.2 Sheren Yones, M.D. Primary Lymphoma of the Bone. Pathology Outlines. http://www.pathologyoutlines.com/topic/bonelymphomageneral.html

Linked-in.jpg