Primary central nervous system lymphoma epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Marjan Khan M.B.B.S.[2]

Overview

Primary CNS lymphoma can develop in immunosuppressed (HIV/AIDS, organ transplant, immunosuppressive agents) or immunocompetent patients. Primary central nervous system lymphoma constitutes approximately 3%-4% of all primary brain tumors and 1%-2% of all lymphomas. Primary central nervous system lymphoma has been diagnosed in at least 2% of individuals infected with human immunodeficiency virus, and in 9–14% of acquired immunodeficiency syndrome (AIDS)-autopsies. Primary CNS lymphoma is, after toxoplasmosis, the most common cause of focal brain lesions in AIDS patients. The overall incidence of primary central nervous system lymphoma is 0.4 per 100,000 individuals per year. The median age of occurrence of primary central nervous system lymphoma in immunocompetent and immunocompromised patients are 53-57 years and 31-35 years, respectively. The peak incidence is between 60 and 70 years old for immunocompetent patients. Significant increment of incidence rate over time is associated with increased incidence of AIDS and advanced age. Males are more commonly affected with primary central nervous system lymphoma than females. The male to female ratio is approximately 1.2 to 1 in immunocompetent patients and approximately 7.38 to 1 in AIDS-associated primary central nervous system lymphoma.

Epidemiology and Demographics

Prevalence

  • Primary central nervous system lymphoma constitutes approximately 3%-4% of all primary brain tumors.[1]
  • Primary CNS lymphoma constitues approximately 1%-2% of all lymphomas.[1]
  • Primary central nervous system lymphoma has been diagnosed in at least 2% of individuals infected with human immunodeficiency virus, and in 9–14% of acquired immunodeficiency syndrome (AIDS)-autopsies.[2]
  • Primary CNS lymphoma is, after toxoplasmosis, the most common cause of focal brain lesions in AIDS patients.[2]

Incidence

  • The overall incidence rate of primary central nervous system lymphoma is 0.4 cases per 100,000 individuals per year.[1]

Age

  • Primary central nervous system lymphoma does not have predilections for any age group.[3]
  • The median age of occurrence of primary central nervous system lymphoma in immunocompetent and immunocompromised patients are 53-57 years and 31-35 years, respectively.[4]
  • The peak incidence is between 60 and 70 years old for immunocompetent patients.[1]
  • Young age of the patient should be noted, because it is not typical for primary CNS lymphoma.
  • Significant increment of incidence rate over time is associated with increased incidence of AIDS and advanced age.

Gender

  • Males are more commonly affected with primary central nervous system lymphoma than females.[1]
  • The male to female ratio is approximately 1.2 to 1 in immunocompetent patients and approximately 7.38 to 1 in AIDS-associated primary central nervous system lymphoma.[4]

References

  1. 1.0 1.1 1.2 1.3 1.4 Manenti, G.; Di Giuliano, F.; Bindi, A.; Liberto, V.; Funel, V.; Garaci, F. G.; Floris, R.; Simonetti, G. (2013). "A Case of Primary T-Cell Central Nervous System Lymphoma: MR Imaging and MR Spectroscopy Assessment". Case Reports in Radiology. 2013: 1–5. doi:10.1155/2013/916348. ISSN 2090-6862.
  2. 2.0 2.1 Haldorsen, Ingfrid S; Kråkenes, Jostein; Goplen, Anne K; Dunlop, Oona; Mella, Olav; Espeland, Ansgar (2008). "AIDS-related primary central nervous system lymphoma: a Norwegian national survey 1989–2003". BMC Cancer. 8 (1): 225. doi:10.1186/1471-2407-8-225. ISSN 1471-2407.
  3. Primary central nervous system lymphoma. Wikipedia 2016. https://en.wikipedia.org/wiki/Primary_central_nervous_system_lymphoma. Accessed on February 18, 2016
  4. 4.0 4.1 Bhagavathi S, Wilson JD (2008). "Primary central nervous system lymphoma". Arch Pathol Lab Med. 132 (11): 1830–4. doi:10.1043/1543-2165-132.11.1830. PMID 18976024.


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