Posaconazole dosage and administration
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]
Dosage and Administration
General
The prescriber should follow the specific dosing instructions for each formulation. The delayed-release tablet and oral suspension are not to be used interchangeably due to the differences in the dosing of each formulation.
Noxafil delayed-release tablets should be swallowed whole, and not be divided, crushed, or chewed. Noxafil delayed-release tablets should be taken with food
Noxafil oral suspension should be administered with a full meal or with a liquid nutritional supplement or an acidic carbonated beverage (e.g., ginger ale) in patients who cannot eat a full meal.
Coadministration of drugs that can decrease the plasma concentrations of posaconazole should generally be avoided unless the benefit outweighs the risk. If such drugs are necessary, patients should be monitored closely for breakthrough fungal infections Patients who have severe diarrhea or vomiting should be monitored closely for breakthrough fungal infections.
Instructions for use with Noxafil Delayed-Release Tablets
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Noxafil is recommended that the spoon is rinsed with water after each administration and before storage.
Administration Information
To enhance the oral absorption of Noxafil and optimize plasma concentrations:
Noxafil delayed-release tablets should be administered with food. Each dose of Noxafil oral suspension should be administered during or immediately (i.e., within 20 minutes) following a full meal. For patients who cannot eat a full meal, Noxafil delayed-release tablets should be used instead of Noxafil oral suspension. Noxafil delayed-release tablets should be used only for the prophylaxis indication. Noxafil delayed-release tablets provide higher plasma drug exposures than Noxafil oral suspension under fasted conditions. In patients who cannot eat a full meal and for whom Noxafil delayed-release tablets are not an option, each dose of Noxafil oral suspension should be administered with a liquid nutritional supplement or an acidic carbonated beverage. For patients who cannot eat a full meal or tolerate an oral nutritional supplement or an acidic carbonated beverage and who do not have the option of taking Noxafil delayed-release tablets, an alternative antifungal therapy should be considered or patients should be monitored closely for breakthrough fungal infections.[1]
References
Adapted from the FDA Package Insert.