Pancreatic insufficiency
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Venkata Sivakrishna Kumar Pulivarthi M.B.B.S [2]
Synonyms and keywords: Exocrine pancreatic insufficiency
Overview
Pancreatic insufficiency is characterized by deficiency of the exocrine pancreatic enzymes, resulting in the inability to digest food properly, or maldigestion.
Causes
Common Causes
- Chronic alcoholism
- Chronic pancreatitis
- Cystic fibrosis
- Gall stones
- Gastrectomy
- Shwachman-Diamond syndrome
- Zollinger-Ellison syndrome
Causes by Organ System
Causes in Alphabetical Order
- Acute intermittent porphyria
- Alagille syndrome
- Alpha-1 antitrypsin deficiency
- Annular pancreas
- Ataxia telangiectasia
- Autoimmune lymphoproliferative syndrome
- Bowel resection
- Celiac disease
- Chronic alcoholism
- Chronic pancreatitis
- Congenital lipomatosis of pancreas
- Congenital pancreatic dysfunction
- Congenital partial lipodystrophy
- Cystic fibrosis
- Diabetic gastroparesis
- Gallstones
- Gastrectomy
- Gestational diabetes
- Havlikova syndrome
- Hemochromatosis
- Hereditary pancreatitis
- Homocystinuria
- Hyperparathyroidism
- Hypertriglyceridemia
- Idiopathic pancreatitis
- Johanson-Blizzard syndrome
- Juvenile tropical pancreatitis syndrome
- Lupus
- Malnutrition
- Mumps
- Pancreatectomy
- Pancreas divisum
- Pancreatic agenesis
- Pancreatic cancer
- Pancreatic cyst
- Pancreatic duct obstruction
- Pancreatic pseudocyst
- Pearson syndrome
- Polyglandular autoimmune syndrome
- Short bowel syndrome
- Shwachman-Diamond syndrome
- Situs inversus totalis with cystic dysplasia of pancreas
- Sjogren's syndrome
- Trauma
- Wolfram's disease
- Zollinger-Ellison syndrome
Diagnosis
History and Symptoms
Differential Diagnosis of Causes of Pancreatic insufficiency
Treatment
Often pancreatic insufficiency is treated with Pancreatic Enzyme Products (PEPs), such as pancrelipase, that are used to breakdown fats (lipases), proteins (proteases) and carbohydrates (amylases) into units that can be digested by those with pancreatic insufficiency. [1]
References