Nuclear receptor coactivator 1

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The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity (EC NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression.[1][2]

NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).


Nuclear receptor coactivator 1 possesses a basic helix-loop-helix (bHLH) domain and has been shown to interact with:


  1. Oñate SA, Tsai SY, Tsai MJ, O'Malley BW (1995). "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily". Science. 270 (5240): 1354–1357. doi:10.1126/science.270.5240.1354. PMID 7481822.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  2. Onate SA, Boonyaratanakornkit V, Spencer TE, Tsai SY, Tsai MJ, Edwards DP, O'Malley BW (1998). "The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors". Journal of Biological Chemistry. 273 (20): 12101–12108. doi:10.1074/jbc.273.20.12101. PMID 9575154.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  3. Masiello D, Chen SY, Xu Y, Verhoeven MC, Choi E, Hollenberg AN, Balk SP (Oct 2004). "Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells". Molecular Endocrinology. 18 (10): 2388–2401. doi:10.1210/me.2003-0436. PMID 15256534.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  4. Ueda T, Mawji NR, Bruchovsky N, Sadar MD (Oct 2002). "Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells". Journal of Biological Chemistry. 277 (41): 38087–38094. doi:10.1074/jbc.M203313200. PMID 12163482.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  5. Bevan CL, Hoare S, Claessens F, Heery DM, Parker MG (Dec 1999). "The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1". Molecular and Cellular Biology. 19 (12): 8383–8392. doi:10.1128/mcb.19.12.8383. PMC 84931. PMID 10567563.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  6. 6.0 6.1 6.2 Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW (Jun 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Molecular Endocrinology. 14 (6): 915–925. doi:10.1210/mend.14.6.0471. PMID 10847592.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  7. 7.0 7.1 Lee SK, Kim HJ, Na SY, Kim TS, Choi HS, Im SY, Lee JW (Jul 1998). "Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits". Journal of Biological Chemistry. 273 (27): 16651–16654. doi:10.1074/jbc.273.27.16651. PMID 9642216.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  8. Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (Nov 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". Journal of Biological Chemistry. 274 (48): 34283–34293. doi:10.1074/jbc.274.48.34283. PMID 10567404.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  9. Tzortzakaki E, Spilianakis C, Zika E, Kretsovali A, Papamatheakis J (Dec 2003). "Steroid receptor coactivator 1 links the steroid and interferon gamma response pathways". Molecular Endocrinology. 17 (12): 2509–2518. doi:10.1210/me.2002-0439. PMID 12933903.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  10. 10.0 10.1 Sheppard HM, Harries JC, Hussain S, Bevan C, Heery DM (Jan 2001). "Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1". Molecular and Cellular Biology. 21 (1): 39–50. doi:10.1128/MCB.21.1.39-50.2001. PMC 86566. PMID 11113179.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  11. Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW (May 2002). "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase". Molecular and Cellular Biology. 22 (10): 3549–3461. doi:10.1128/MCB.22.10.3549-3561.2002. PMC 133790. PMID 11971985.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  12. Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R (Nov 1998). "Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1". Genes & Development. 12 (22): 3488–3498. doi:10.1101/gad.12.22.3488. PMC 317237. PMID 9832502.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  13. 13.0 13.1 13.2 Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (Mar 2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO Journal. 20 (6): 1341–1352. doi:10.1093/emboj/20.6.1341. PMC 145523. PMID 11250900.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  14. DiRenzo J, Shang Y, Phelan M, Sif S, Myers M, Kingston R, Brown M (Oct 2000). "BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation". Molecular and Cellular Biology. 20 (20): 7541–7549. doi:10.1128/MCB.20.20.7541-7549.2000. PMC 86306. PMID 11003650.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  15. Kalkhoven E, Valentine JE, Heery DM, Parker MG (Jan 1998). "Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor". EMBO Journal. 17 (1): 232–243. doi:10.1093/emboj/17.1.232. PMC 1170374. PMID 9427757.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  16. Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proceedings of the National Academy of Sciences, USA. 99 (5): 2642–2647. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  17. Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA (Apr 2001). "Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140". Molecular Endocrinology. 15 (4): 501–511. doi:10.1210/mend.15.4.0624. PMID 11266503.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  18. Kucera T, Waltner-Law M, Scott DK, Prasad R, Granner DK (Jul 2002). "A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1". Journal of Biological Chemistry. 277 (29): 26098–260102. doi:10.1074/jbc.M204013200. PMID 12118039.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  19. Na SY, Lee SK, Han SJ, Choi HS, Im SY, Lee JW (May 1998). "Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations". Journal of Biological Chemistry. 273 (18): 10831–10834. doi:10.1074/jbc.273.18.10831. PMID 9556555.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  20. Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai MJ, O'Malley BW (Sep 1997). "Steroid receptor coactivator-1 is a histone acetyltransferase". Nature. 389 (6647): 194–198. doi:10.1038/38304. PMID 9296499.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  21. Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM (Nov 1999). "Activation of PPARgamma coactivator-1 through transcription factor docking". Science. 286 (5443): 1368–1371. doi:10.1126/science.286.5443.1368. PMID 10558993.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  22. Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (Dec 1997). "p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha". Journal of Biological Chemistry. 272 (52): 33435–33443. doi:10.1074/jbc.272.52.33435. PMID 9407140.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  23. Treuter E, Albrektsen T, Johansson L, Leers J, Gustafsson JA (Jun 1998). "A regulatory role for RIP140 in nuclear receptor activation". Molecular Endocrinology. 12 (6): 864–881. doi:10.1210/mend.12.6.0123. PMID 9626662.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  24. Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN (Nov 2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". Journal of Biological Chemistry. 276 (44): 40614–40620. doi:10.1074/jbc.M106263200. PMID 11514567.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  25. Giraud S, Bienvenu F, Avril S, Gascan H, Heery DM, Coqueret O (Mar 2002). "Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a". Journal of Biological Chemistry. 277 (10): 8004–811. doi:10.1074/jbc.M111486200. PMID 11773079.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  26. Litterst CM, Pfitzner E (Dec 2001). "Transcriptional activation by STAT6 requires the direct interaction with NCoA-1". Journal of Biological Chemistry. 276 (49): 45713–45721. doi:10.1074/jbc.M108132200. PMID 11574547.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  27. Litterst CM, Pfitzner E (Sep 2002). "An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1". Journal of Biological Chemistry. 277 (39): 36052–36060. doi:10.1074/jbc.M203556200. PMID 12138096.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  28. Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW (Sep 1999). "Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation". Molecular and Cellular Biology. 19 (9): 6323–6332. doi:10.1128/mcb.19.9.6323. PMC 84603. PMID 10454579.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  29. Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM (Oct 1998). "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors". Endocrinology. 139 (10): 4197–4204. doi:10.1210/endo.139.10.6218. PMID 9751500.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  30. Jeyakumar M, Tanen MR, Bagchi MK (Jun 1997). "Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor". Molecular Endocrinology. 11 (6): 755–767. doi:10.1210/mend.11.6.0003. PMID 9171239.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

External links

Further reading

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  • Qi C, Zhu Y, Reddy JK (2001). "Peroxisome proliferator-activated receptors, coactivators, and downstream targets". Cell Biochemistry and Biophysics. 32. Spring: 187–204. PMID 11330046.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>